Patents by Inventor Nikolai Sharkov

Nikolai Sharkov has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Detection of ligand-antiligand complex formation by electromagnetically detectable bulk property measurement
    Patent number: 7011948
    Abstract: Disclosed are methods for analyzing molecular binding events in which the formation of ligand/antiligand complexes can be directly detected in a mixture without requiring separation of the components of the mixture from each other by measuring bulk properties of the mixture (i.e., properties that have contributions from several or all of the components present in the mixture). Using these techniques, it is possible to screen libraries without labeling either the target antiligand or ligand. The invention also provides a method for determining the strength of ligand/antiligand binding by further analysis of the same signals.
    Type: Grant
    Filed: July 17, 2002
    Date of Patent: March 14, 2006
    Assignee: MDS Sciex
    Inventors: Robert G. Chapman, Pejman Ghanouni, Igor Shmulevich, David Balaban, Joseph A. Heanue, Andrew P. May, Nikolai Sharkov
  • Detection of ligand/antiligand complex formation by electromagnetically detectable bulk property measurement
    Publication number: 20040014045
    Abstract: Disclosed are methods for analyzing molecular binding events in which the formation of ligand/antiligand complexes can be directly detected in a mixture without requiring separation of the components of the mixture from each other by measuring bulk properties of the mixture (i.e., properties that have contributions from several or all of the components present in the mixture). Using these techniques, it is possible to screen libraries without labeling either the target antiligand or ligand. The invention also provides a method for determining the strength of ligand/antiligand binding by further analysis of the same signals.
    Type: Application
    Filed: July 17, 2002
    Publication date: January 22, 2004
    Applicant: Signature BioScience Inc. a corporation of California
    Inventors: Robert G. Chapman, Pejman Ghanouni, Igor Shmulevich, David Balaban, Joseph A. Heanue, Andrew P. May, Nikolai Sharkov