Abstract: The present invention relates to virally expressed peptides which bind to PDZ domains and thereby block PDZ domain mediated protein-protein interactions and expression vectors encoding these peptides. The virally expressed peptides comprise an oligomerization domain, capable of forming higher order constructs, such as trimers or tetramers, and a peptide ligand capable of binding to a PDZ domain. The invention furthermore relates to therapeutic use of said peptides and expression vectors encoding these peptides.

Abstract: The present invention relates to the use of a pharmaceutical composition comprising at least one strontium salts for the preparation of a medicament for treatment and prevention of gingivitis, periodontitis (aggressive and chronic), periodontitis as a manifestation of systemic diseases and/or necrotizing periodontal diseases. The composition preferably comprises strontium carbonate, strontium chlorides and/or strontium renalate. Further included may be a vitamin D compound, preferably vitamin D3.

Abstract: A method, computer system and computer program product for providing a computer simulation that provides advance notification of expected events or states, comprising running a first computer simulation; running a second computer simulation corresponding to said first simulation, said second simulation having progressed further than said first simulation; and using said second computer simulation to provide information representing expected future events in said first simulation. A first computer simulation may be based on a model of a simulated system, said model having a plurality of state variables. Input data from a first user input interface may represent user interaction with said first computer simulation, while input data from a second user input interface may represent the extent to which a condition should be present in said simulation.

Abstract: The present invention relates to the use of a pharmaceutical composition comprising at least one strontium salts for the preparation of a medicament for treatment and prevention of gingivitis, periodontitis (aggressive and chronic), periodontitis as a 5 manifestation of systemic diseases and/or necrotizing periodontal diseases. The composition preferably comprises strontium carbonate, strontium chlorides and/or strontium renalate. Further included may be a vitamin D compound, preferably vitamin D3.

Abstract: A method, computer system and computer program product for providing a computer simulation that provides advance notification of expected events or states, comprising running a first computer simulation; running a second computer simulation corresponding to said first simulation, said second simulation having progressed further than said first simulation; and using said second computer simulation to provide information representing expected future events in said first simulation. A first computer simulation may be based on a model of a simulated system, said model having a plurality of state variables. Input data from a first user input interface may represent user interaction with said first computer simulation, while input data from a second user input interface may represent the extent to which a condition should be present in said simulation.