Patents by Inventor Nikolaj Eusebius Jakobsen

Nikolaj Eusebius Jakobsen has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Patent number: 11931556
    Abstract: The present invention provides a drug injection device (100, 100?, 100?) comprising a first element (130) and a second element (102, 102?, 102?) configured to undergo movement relative to each other corresponding to an action performed on or by the drug injection device (100, 100?, 100?), wherein the first element (130) comprises serially disposed protrusions (133), and wherein the second element (102, 102?, 102?) comprises a second element base and a deflectable transducer (170, 170?, 170?). The deflectable transducer (170, 170?, 170?) defines a base portion attached to the second element base, and a deflectable portion (162) configured for sequentially cooperating with the plurality of protrusions (133), wherein a processor (165) is electrically connected with the deflectable transducer (170, 170?, 170?) to register activation signals.
    Type: Grant
    Filed: February 2, 2019
    Date of Patent: March 19, 2024
    Assignee: Novo Nordisk A/S
    Inventors: Nikolaj Eusebius Jakobsen, Per Einar Pontus Holm
  • Publication number: 20240066235
    Abstract: The invention relates to a medical injection device for dispensing substantially equally sized dose volumes of a liquid drug. The injection is driven by a torsion spring which is strained prior to each dose release by rotation of a connector element connecting the torsion spring to the rotational drive structure. The dose release is controlled by an axial movement of the rotational drive structure which can only be moved axially when the connector element has been rotated to a specific rotational position.
    Type: Application
    Filed: January 14, 2022
    Publication date: February 29, 2024
    Applicant: Novo Nordisk A/S
    Inventor: Nikolaj Eusebius Jakobsen
  • Publication number: 20230277823
    Abstract: A capsule (100) suitable for insertion into a gastrointestinal lumen. The capsule (100) comprises: a capsule housing (110, 120), a reservoir (A) accommodating a drug substance, a drug outlet (190), an actuation chamber (118), a movable separator (160) between the actuation chamber (118) and the reservoir (A), and a drive system comprising a gas expansion unit (150) and a trigger (145, 140, 170). The gas expansion unit (150) comprises a gas gate (151) and the trigger (145, 140, 170) comprises a trigger member (170) and a swellable portion (140) comprising sponge material, wherein wetting of the sponge material causes swelling of the sponge material thereby causing relative movement between the gas expansion unit (150) and the trigger member (170) to open the gas gate (151). Pressurized gas flows from them to the actuation chamber (118) thereby exerting load on the separator (160) for expelling the drug substance.
    Type: Application
    Filed: August 5, 2021
    Publication date: September 7, 2023
    Inventors: Brian Mouridsen, Jacob Pyung Hwa Jepsen, Nikolaj Eusebius Jakobsen, Drago Sticker, Aghiad Ghazal
  • Publication number: 20230248917
    Abstract: The invention relates to an injection device wherein the drive element transferring rotation to the piston rod is divided into two elements which are able to move axially in relation to each other such that the drive mechanism can be released to allow the user to reset the piston rod and change the cartridge.
    Type: Application
    Filed: July 12, 2021
    Publication date: August 10, 2023
    Inventors: Nikolaj Eusebius Jakobsen, Ebbe Kiilerich, Lee Higson
  • Publication number: 20230081038
    Abstract: A dosage sensing module for or in a pen drug delivery device and comprising a power source unit, a processor unit and a dosage sensor unit with a first sensor part adapted to be fixed to a part not rotating during dose expelling and comprising a flexible printed circuit board sheet on which a pattern of individual electrical conductive sensor areas are arranged. The sensor unit further comprises a second sensor part adapted to be fixed to the piston rod to follow the rotation thereof during dose expelling. The second sensor part comprises individual structures that together with the conductive sensor areas are adapted to, upon relative rotational movement between the first and second sensor part, provide electrical signals to a processor unit indicative of the relative rotational position between the first and second sensor part.
    Type: Application
    Filed: November 22, 2022
    Publication date: March 16, 2023
    Inventors: Carsten Schau Andersen, Dave Szakelyhidi, Jakob Oest Wielandt, Matthew William Haave, Blake Matsuzaki, Gregory A. Kirkos, Nikolaj Eusebius Jakobsen
  • Patent number: 11534554
    Abstract: A dosage sensing module for or in a pen drug delivery device and comprising a power source unit, a processor unit and a dosage sensor unit with a first sensor part adapted to be fixed to a part not rotating during dose expelling and comprising a flexible printed circuit board sheet on which a pattern of individual electrical conductive sensor areas are arranged. The sensor unit further comprises a second sensor part adapted to be fixed to the piston rod to follow the rotation thereof during dose expelling. The second sensor part comprises individual structures that together with the conductive sensor areas are adapted to, upon relative rotational movement between the first and second sensor part, provide electrical signals to a processor unit indicative of the relative rotational position between the first and second sensor part.
    Type: Grant
    Filed: January 22, 2018
    Date of Patent: December 27, 2022
    Assignee: NOVO NORDISK A/S
    Inventors: Carsten Schau Andersen, Dave Szakelyhidi, Jakob Oest Wielandt, Matthew William Haave, Blake Matsuzaki, Gregory A. Kirkos, Nikolaj Eusebius Jakobsen
  • Publication number: 20220387725
    Abstract: The present invention provides a piston rod displacement mechanism for a pen injection device, comprising: a tubular housing (2) extending along a reference axis and comprising an interior housing surface (3) with a first engagement structure (4), a nut member (5) fixed within the tubular housing (2), a piston rod (15) comprising a first non-self-locking thread (18) having a first thread direction and a first thread pitch and being engaged with the nut member (5), and a second non-self-locking thread (17) superposed on the first non-self-locking thread (18), the second non-self-locking thread (17) having a second thread direction and a second thread pitch, and a dose dial sleeve (20) operable to advance the piston rod (15) in the nut member (5), the dose dial sleeve (20) comprising an exterior sleeve surface (21) with a second engagement structure (24) being in sliding engagement with the first engagement structure (4), and an interior sleeve surface (23) with a third engagement structure (29) being engaged w
    Type: Application
    Filed: December 3, 2020
    Publication date: December 8, 2022
    Inventor: Nikolaj Eusebius Jakobsen
  • Publication number: 20220379040
    Abstract: The present invention provides a sensor module adapted to be arranged in a cartridge based drug delivery device between a rotatable piston rod and a cartridge piston for capturing dose data from a dose expelling event, the sensor module (50) extending along a reference axis and comprising: a first module part (51) adapted to engage the cartridge piston and comprising anti-rotation means for establishing a frictional interface to the cartridge to impede rotation of the first module part (51) relative thereto, a second module part (54) adapted to engage the rotatable piston rod, and sensor means (52, 152, 252; 53, 153, 253) adapted to detect an extent of relative rotational motion between the first module part (51) and the second module part (54), wherein the anti-rotation means comprises a plurality of radially outwardly projecting studs (51.1; 351.1; 451.1), each comprising a contact surface (51.8; 351.8; 451.8, 451.9) adapted to establish frictional contact with an interior surface of the cartridge.
    Type: Application
    Filed: August 26, 2020
    Publication date: December 1, 2022
    Applicant: Novo Nordisk A/S
    Inventors: Janus Helbo, Nikolaj Eusebius Jakobsen
  • Publication number: 20220362479
    Abstract: The present invention provides a sensor module (50) adapted to be arranged in a cartridge based drug delivery device between a rotatable piston rod and a cartridge piston. The sensor module (50) comprises a first sensor structure (52, 152, 252, 352) adapted to be at least substantially rotationally locked with respect to the cartridge piston and comprising a transversal sensor surface (52.2, 152.2, 252.2, 352.2), and a second sensor structure (53, 153, 253, 353) adapted to be rotationally locked with respect to the piston rod and comprising one or more flexibly supported and axially deflectable contact members (53.1, 53.2, 153.2, 253.2, 353.1, 353.2), which are positioned distally of the transversal sensor surface (52.2, 152.2, 252.2, 352.2) and are adapted to apply a proximally directed force thereto. The first sensor structure (52, 152, 252, 352) and the second sensor structure (53, 153, 253, 353) are adapted to undergo relative rotational motion, whereby the one or more contact members (53.1, 53.2, 153.
    Type: Application
    Filed: October 8, 2020
    Publication date: November 17, 2022
    Applicant: Novo Nordisk A/S
    Inventor: Nikolaj Eusebius Jakobsen
  • Patent number: 11400225
    Abstract: The invention provides a pen-type injection device (1) with a piston rod brake mechanism for improving the determination of an expelled dose.
    Type: Grant
    Filed: May 7, 2018
    Date of Patent: August 2, 2022
    Assignee: Novo Nordisk A/S
    Inventors: Nikolaj Eusebius Jakobsen, Steffen Hansen
  • Patent number: 11400227
    Abstract: The present invention provides a drug injection device (1) for delivering multiple doses of drug, comprising: a housing (2) extending along a main axis, a dose expelling mechanism comprising a piston rod (60) configured to move relative to the housing (2) from a first position to a second position to cause ejection of a dose of drug, the piston rod (60) extending between a proximal piston rod end and a distal piston rod end and comprising a dosing track (63), the piston rod (60) further being movable relative to the housing (2) from an initial pre-use position to a final end stop position to cause accumulated ejection of a predefined total dose, a dosing track follower (17) fixed with respect to the housing (2) and adapted to travel the dosing track (63) during dose ejection, a dose setting mechanism operable to set the dose to be ejected by the dose expelling mechanism, electronic means (82, 90, 91, 92, 95) for registering a dose setting operation and for registering a dose size of an ejected dose, and a dis
    Type: Grant
    Filed: April 6, 2018
    Date of Patent: August 2, 2022
    Assignee: Novo Nordisk A/S
    Inventor: Nikolaj Eusebius Jakobsen
  • Publication number: 20210338933
    Abstract: An autoinjection device (10?) for expelling a dose of drug is described.
    Type: Application
    Filed: July 17, 2019
    Publication date: November 4, 2021
    Inventor: Nikolaj Eusebius Jakobsen
  • Publication number: 20210008296
    Abstract: The present invention provides an injection device (1, 101, 201) comprising a housing (2, 102, 202), a cartridge (30, 130, 230) holding a medical substance and comprising an outlet and a piston (31, 131, 231), a dose expelling mechanism comprising a piston rod system (10, 50, 110, 150, 210, 250) adapted to be moved relative to the housing (2, 102, 202) during a dose expelling action to thereby advance the piston (31, 131, 231) in the cartridge (30, 130, 230), and a ratchet arm (12) operatively coupled with the piston rod system (10, 50, 110, 150, 210, 250) and configured to undergo a deflecting motion relative to the housing (2, 102, 202) during a particular movement of the piston rod system (10, 50, 110, 150, 210, 250) which corresponds to a predetermined volume of the medical substance being expelled from the cartridge (30, 130, 230), the deflecting motion comprising a first part motion which decelerates the piston rod system (10, 50, 110, 150, 210, 250) followed by a second part motion which accelerates th
    Type: Application
    Filed: September 14, 2018
    Publication date: January 14, 2021
    Applicant: Novo Nordisk A/S
    Inventor: Nikolaj Eusebius JAKOBSEN
  • Publication number: 20200360616
    Abstract: The present invention provides a drug injection device (100, 100?, 100?) comprising a first element (130) and a second element (102, 102?, 102?) configured to undergo movement relative to each other corresponding to an action performed on or by the drug injection device (100, 100?, 100?), wherein the first element (130) comprises serially disposed protrusions (133), and wherein the second element (102, 102?, 102?) comprises a second element base and a deflectable transducer (170, 170?, 170?). The deflectable transducer (170, 170?, 170?) defines a base portion attached to the second element base, and a deflectable portion (162) configured for sequentially cooperating with the plurality of protrusions (133), wherein a processor (165) is electrically connected with the deflectable transducer (170, 170?, 170?) to register activation signals.
    Type: Application
    Filed: February 2, 2019
    Publication date: November 19, 2020
    Inventors: Nikolaj Eusebius Jakobsen, Per Einar Pontus Holm
  • Patent number: 10835683
    Abstract: A drug delivery system comprises an indicator element and a sensor system. The indicator element is arranged to rotate relative to a reference component and corresponding to a reference axis and comprises a plurality of dipole magnets. The sensor system comprises a plurality of magnetometers arranged non-rotational relative to the reference component and adapted to determine continuous magnetic field values from the plurality of dipole magnets, as well as processor means configured to determine on the basis of measured values from the plurality of magnetometers a rotational position and/or a rotational movement of the indicator element.
    Type: Grant
    Filed: June 15, 2020
    Date of Patent: November 17, 2020
    Assignee: Novo Nordisk A/S
    Inventors: Nikolaj Eusebius Jakobsen, Preben Mikael Nielsen, Nikolaj Frogner Krusell, Laurits Hoejgaard Olesen
  • Publication number: 20200306456
    Abstract: A drug delivery system comprises an indicator element and a sensor system. The indicator element is arranged to rotate relative to a reference component and corresponding to a reference axis and comprises a plurality of dipole magnets. The sensor system comprises a plurality of magnetometers arranged non-rotational relative to the reference component and adapted to determine continuous magnetic field values from the plurality of dipole magnets, as well as processor means configured to determine on the basis of measured values from the plurality of magnetometers a rotational position and/or a rotational movement of the indicator element.
    Type: Application
    Filed: June 15, 2020
    Publication date: October 1, 2020
    Inventors: Nikolaj Eusebius Jakobsen, Preben Mikael Nielsen, Nikolaj Frogner Krusell, Laurits Hoejgaard Olesen
  • Publication number: 20200206428
    Abstract: The invention provides a pen-type injection device (1) with a piston rod brake mechanism for improving the determination of an expelled dose.
    Type: Application
    Filed: May 7, 2018
    Publication date: July 2, 2020
    Applicant: Novo Nordisk A/S
    Inventors: Nikolaj Eusebius Jakobsen, Steffen Hansen
  • Patent number: 10695504
    Abstract: A drug delivery system comprises means to create a log of expelled dose amounts of drug. Stored dose amounts determined within a given time period are combined to a single combined dose amount. The given time period is initiated by a detected expelling event taking place (i) a given amount of time after a previous detected expelling event, or (ii) after a given detected action. By this arrangement it is possible to create a log corresponding to what a user considers to be a single dose, i.e. combining “split doses” to create a single log entry for a per se split dose.
    Type: Grant
    Filed: April 3, 2014
    Date of Patent: June 30, 2020
    Assignee: Novo Nordisk A/S
    Inventors: Preben Mikael Nielsen, Nikolaj Frogner Krusell, Jens Christian Andersen, Nikolaj Eusebius Jakobsen
  • Patent number: 10682469
    Abstract: A drug delivery system comprises an indicator element and a sensor system. The indicator element is arranged to rotate relative to a reference component and corresponding to a reference axis and comprises a magnetic ring. The sensor system comprises a plurality of magnetometers arranged non-rotational relative to the reference component and adapted to determine continuous magnetic field values from the plurality of dipole magnets, as well as processor means configured to determine on the basis of measured values from the plurality of magnetometers a rotational position and/or a rotational movement of the indicator element.
    Type: Grant
    Filed: January 2, 2020
    Date of Patent: June 16, 2020
    Assignee: Novo Nordisk A/S
    Inventors: Nikolaj Eusebius Jakobsen, Preben Mikael Nielsen, Nikolaj Frogner Krusell, Laurits Hoejgaard Olesen
  • Patent number: 10603442
    Abstract: A logging device adapted to be attached to a pen drug delivery device (210) and capture a property value related to the dose amount of drug expelled from the drug delivery device during an expelling event, the logging device comprising a bore in which a snap lock with a flexible wire portion is arranged circumferentially in the bore, the wire being adapted to be moved laterally by a projection on the pen device and subsequently snap inwardly when the pen device is inserted axially in the bore. In this way an axial snap lock is provided between the logging device and the drug delivery device.
    Type: Grant
    Filed: August 25, 2015
    Date of Patent: March 31, 2020
    Assignee: Novo Nordisk A/S
    Inventors: Nikolaj Eusebius Jakobsen, Ian McLoughlin