Patents by Inventor Nikolaos Avlonitis
Nikolaos Avlonitis has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Patent number: 10648979Abstract: A probe is provided comprising a label and a binding moiety, wherein the binding moiety is adapted to bind to gram-negative bacteria, and to substantially not bind to animal cells or gram-positive bacteria. A method of detecting the presence of bacteria in a target area is also provided, which allows the detection of bacteria generally, and the determination of whether that bacteria is gram negative or gram positive.Type: GrantFiled: November 13, 2015Date of Patent: May 12, 2020Assignee: The University Court of the University of EdinburghInventors: Mark Bradley, Annamaria Helena Lilienkampf, Nikolaos Avlonitis, Marc Vendrell Escobar, Neil Alexander McDonald, Christopher Haslett, Kanwaldeep Dhaliwal, Timothy Simon Walsh
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Patent number: 10520504Abstract: A probe for detecting bacteria and/or fungi in vitro and in vivo is provided, the probe having a core and a plurality of probe elements; each probe element within the plurality of probe elements extending from the core and having a fluorophore and a binding moiety, wherein the binding moiety is a bacteria binding moiety and selectively binds to bacteria and/or to fungi and not to animal cells. Methods of use of the probe and kits comprising the probe are also provided.Type: GrantFiled: November 13, 2015Date of Patent: December 31, 2019Assignee: The University Court of the University of EdinburghInventors: Mark Bradley, Annamaria Helena Lilienkampf, Nikolaos Avlonitis, Marc Vendrell Escobar, Neil Alexander McDonald, Christopher Haslett, Kanwaldeep Dhaliwal, Timothy Simon Walsh
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Patent number: 10434191Abstract: The present invention relates to methods of visualising cells especially although not exclusively in vivo using a dye, such as a dendrimer-dye molecule or polybranched-dye molecule which is internalised by the cells and thus permits subsequent visualisation by confocal fluorescence endomicroscopy or other optical detectors. There is also provided internally quenched probes for use in visualising cells especially although not exclusively in vivo by confocal fluorescence endomicroscopy and the use of internally quenched probes in combination with confocal fluorescence endomicroscopy, for visualising cells by virtue of internalisation and dequenching of a probe by the cells. In a particular embodiment the cells are activated neutrophils, such as within the lung of a subject.Type: GrantFiled: January 23, 2017Date of Patent: October 8, 2019Assignee: THE UNIVERSITY COURT OF THE UNIVERSITY OF EDINBURGHInventors: Tashfeen Walton, Mark Bradley, Kev Dhaliwal, Nikolaos Avlonitis, Chris Haslett, Neil McDonald, Manuelle Debunne
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Publication number: 20180231548Abstract: A probe is provided comprising a label and a binding moiety, Deliver First Probe wherein the binding moiety is adapted to bind to gram-negative bacteria, and to Target Area to substantially not bind to animal cells or gram-positive bacteria. A method of detecting the presence of bacteria in a target area is also provided, which allows the detection of bacteria generally, and the determination of whether that bacteria is gram negative or gram positive.Type: ApplicationFiled: November 13, 2015Publication date: August 16, 2018Inventors: Mark BRADLEY, Annamaria Helena LILIENKAMPF, Nikolaos AVLONITIS, Marc Vendrell ESCOBAR, Neil Alexander MCDONALD, Christopher HASLETT, Kanwaldeep DHALIWAL, Timothy Simon WALSH
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Publication number: 20180120314Abstract: A probe is provided comprising a core and a plurality of probe elements; each probe element within the plurality of probe elements extending from the core and comprising a fluorophore and a binding moiety. Methods of use of the probe and kits comprising the probe are also provided.Type: ApplicationFiled: November 13, 2015Publication date: May 3, 2018Inventors: Mark BRADLEY, Annamaria Helena LILIENKAMPF, Nikolaos AVLONITIS, Marc Vendrell ESCOBAR, Neil Alexander MCDONALD, Christopher HASLETT, Kanwaldeep DHALIWAL, Timothy Simon WALSH
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Patent number: 9777037Abstract: The present invention relates to novel neurosteroid derivatives with anti-apoptotic, neuroprotective and neurogenic properties that act on the nervous system as well as methods for making the same and their applications in the treatment and/or prevention or amelioration of neurodegenerative diseases related to neuronal apoptosis or neuronal injury, or conditions related to or resulting from apoptosis, including but not limited to Alzheimer's disease, Parkinson's disease, Huntington's disease, multiple sclerosis and amyotrophic lateral sclerosis (ALS), retinal degeneration and detachment, peripheral neuropathy caused by genetic abnormalities, diabetes, polio, herpes, AIDS and chemotherapy, brain trauma, or ischemia and stroke. The active compounds are represented by Formula (I): wherein R1, R2, R3, R4, R5, R6, R7, A, B, X, Y and Z are defined in the description of the invention. The present invention also includes compositions which comprise one or more of the compounds of Formula (I).Type: GrantFiled: June 17, 2008Date of Patent: October 3, 2017Assignee: BIONATURE E. A. LTD.Inventors: Achilleas Gravanis, Theodora Calogeropoulou, Elias Castanas, Andreas Margioris, Ioannis Charalambopoulos, Nikolaos Avlonitis, Vassilios Minas, Vasileia-Ismini Alexaki, Christos Tsatsanis, Michael N. Alexis, Eumorphia Remboutsika, Varvara Vergou, Constantinos Neophytou
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Publication number: 20170196995Abstract: The present invention relates to methods of visualising cells especially although not exclusively in vivo using a dye, such as a dendrimer-dye molecule or polybranched-dye molecule which is internalised by the cells and thus permits subsequent visualisation by confocal fluorescence endomicroscopy or other optical detectors. There is also provided internally quenched probes for use in visualising cells especially although not exclusively in vivo by confocal fluorescence endomicroscopy and the use of internally quenched probes in combination with confocal fluorescence endomicroscopy, for visualising cells by virtue of internalisation and dequenching of a probe by the cells. In a particular embodiment the cells are activated neutrophils, such as within the lung of a subject.Type: ApplicationFiled: January 23, 2017Publication date: July 13, 2017Applicant: THE UNIVERSITY COURT OF THE UNIVERSITY OF EDINBURGHInventors: Tashfeen WALTON, Mark BRADLEY, Kev DHALIWAL, Nikolaos AVLONITIS, Chris HASLETT, Neil MCDONALD, Manuelle DEBUNNE
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Patent number: 9549997Abstract: The present invention relates to methods of visualizing cells especially although not exclusively in vivo using a dye, such as a dendrimer-dye molecule or polybranched-dye molecule which is internalized by the cells and thus permits subsequent visualization by confocal fluorescence endomicroscopy or other optical detectors. There is also provided internally quenched probes for use in visualizing cells especially although not exclusively in vivo by confocal fluorescence endomicroscopy and the use of internally quenched probes in combination with confocal fluorescence endomicroscopy, for visualizing cells by virtue of internalization and dequenching of a probe by the cells. In a particular embodiment the cells are activated neutrophils, such as within the lung of a subject.Type: GrantFiled: April 5, 2012Date of Patent: January 24, 2017Assignee: THE UNIVERSITY COURT OF THE UNIVERSITY OF EDINBURGHInventors: Tashfeen Walton, Mark Bradley, Kev Dhaliwal, Nikolaos Avlonitis, Chris Haslett, Neil McDonald, Manuelle Debunne
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Publication number: 20140134110Abstract: The present invention relates to methods of visualising cells especially although not exclusively in vivo using a dye, such as a dendrimer-dye molecule or polybranched-dye molecule which is internalised by the cells and thus permits subsequent visualisation by confocal fluorescence endomicroscopy or other optical detectors. There is also provided internally quenched probes for use in visualising cells especially although not exclusively in vivo by confocal fluorescence endomicroscopy and the use of internally quenched probes in combination with confocal fluorescence endomicroscopy, for visualising cells by virtue of internalisation and dequenching of a probe by the cells. In a particular embodiment the cells are activated neutrophils, such as within the lung of a subject.Type: ApplicationFiled: April 5, 2012Publication date: May 15, 2014Inventors: Tashfeen Walton, Mark Bradley, Kev Dhaliwal, Nikolaos Avlonitis, Chris Haslett, Neil McDonald, Manuelle Debunne
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Patent number: 8097752Abstract: Disclosed are novel ring containing phospholipids represented by the structural formula A-X—PO3—W and physiologically acceptable salts thereof and a process for the preparation of these compounds. The compounds can be used for the treatment of protozoal diseases and especially leishmaniasis.Type: GrantFiled: October 29, 2003Date of Patent: January 17, 2012Assignee: MAKScientific, LLCInventors: Theodora Calogeropoulou, Maria Koufaki, Nikolaos Avlonitis, Alexandros Makriyannis
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Publication number: 20100234335Abstract: The present invention relates to novel neurosteroid derivatives with anti-apoptotic, neuroprotective and neurogenic properties that act on the nervous system as well as methods for making the same and their applications in the treatment and/or prevention or amelioration of neurodegenerative diseases related to neuronal apoptosis or neuronal injury, or conditions related to or resulting from apoptosis, including but not limited to Alzheimer's disease, Parkinson's disease, Huntington's disease, multiple sclerosis and amyotrophic lateral sclerosis (ALS), retinal degeneration and detachment, peripheral neuropathy caused by genetic abnormalities, diabetes, polio, herpes, AIDS and chemotherapy, brain trauma, or ischemia and stroke. The active compounds are represented by Formula (I): wherein R1, R2, R3, R4, R5, R6, R7, A, B, X, Y and Z are defined in the description of the invention. The present invention also includes compositions which comprise one or more of the compounds of Formula (I).Type: ApplicationFiled: June 17, 2008Publication date: September 16, 2010Applicant: BIONATURE E. A. LTD.Inventors: Achilleas Gravanis, Theodora Calogeropoulou, Elias Castanas, Andreas Margioris, Ioannis Charalambopoulos, Nikolaos Avlonitis, Vassilios Minas, Vasileia-Ismini Alexaki, Christos Tsatsanis, Michael N. Alexis, Eumorphia Remboutsika, Varvara Vergou, Constantinos Neophytou
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Publication number: 20060105998Abstract: Disclosed are novel ring containing phospholipids represented by the structural formula A-X—PO3—W and physiologically acceptable salts thereof and a process for the preparation of these compounds. The compounds can be used for the treatment of protozoal diseases and especially leishmaniasis.Type: ApplicationFiled: October 29, 2003Publication date: May 18, 2006Applicant: MAK Scientific CorporationInventors: Theodora Calogeropoulou, Maria Koufaki, Nikolaos Avlonitis, Alexandros Makriyannis