Abstract: Methods and systems for predicting part reliability in energy infrastructure are disclosed. One such method includes collecting a time-series history of failures for each failure mode of a plurality of failure modes occurring in one or more energy infrastructure assets of an energy infrastructure. The method also includes fitting a failure model to each failure mode within the plurality of failure modes, and calculating a mean time between failures and a variance associated with failure time as a function of time. The method further includes calculating times of changes in each of a plurality of preventative and mitigative barriers and interrelationships among barriers to determine a schedule of inspection, maintenance, and repair activities, based on a cost of the associated activity and the failure model for each failure mode as a function of time when time series data sets representative of the associated barrier are included as process inputs.