Patents by Inventor Nikolaos Stergiopulos
Nikolaos Stergiopulos has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Publication number: 20240091538Abstract: An implantable stimulation system having a stimulation unit coupled to a programmable controller, a stimulation circuit and an array of electrodes disposed on a pair of flexible paddles is provided for selectively stimulating at least one pelvic (e.g., cavernous) nerve. The programmable controller is pre-programmed to run an excitation electrode routine that selectively scans the electrode arrays with a series of directional current flows to optimize electrode selection for use in stimulating a nerve. The implantable stimulation system may be programmed to run a first stimulation pulse sequence corresponding to a first mode for invoking a rapid erectile response, a second nerve rehabilitation stimulation mode for rehabilitating neural transmission in a cavernous nerve, a third penile rehabilitation mode for reducing penile fibrosis, and/or a fourth bladder nerve rehabilitation mode for rehabilitating neural transmission in nerves that control the lower urinary tract.Type: ApplicationFiled: February 8, 2022Publication date: March 21, 2024Applicant: Comphya SAInventors: Rodrigo Araujo FRAGA DA SILVA, Nikolaos STERGIOPULOS, Mikael Nils STURNY, Fiona JOSEPH
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Publication number: 20240091063Abstract: An ocular drainage system is provided for treating diseases that produce elevated intraocular pressures, such as glaucoma, wherein the system includes an implantable device and an external control unit, the implantable device includes a non-invasively adjustable valve featuring at least one deformable tube and a disk rotatably mounted within a housing, such that rotation of the disk using the external control unit causes the disk to apply a selected amount of compression to the deformable tube, thereby adjusting the fluidic resistance of the deformable tube and regulating the intraocular pressure.Type: ApplicationFiled: July 26, 2023Publication date: March 21, 2024Applicant: ECOLE POLYTECHNIQUE FEDERALE DE LAUSANNE (EPFL)Inventors: Stephane BIGLER, Nikolaos STERGIOPULOS
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Patent number: 11779489Abstract: Apparatus and methods are provided for treating diseases that produce elevated intraocular pressures, such as glaucoma, wherein the device includes a housing shell defining a cavity between a first end and a second end of the housing shell, and an elastic membrane disposed within the cavity to divide the cavity into a fluidic channel that permits a flow of fluid from the first end to the second end and a sealed cavity. The elastic membrane deforms to change the volume of the sealed cavity responsive to pressure fluctuations between the first and second ends, thereby varying the fluidic resistance of the flow of fluid through the fluidic channel.Type: GrantFiled: March 1, 2021Date of Patent: October 10, 2023Assignee: Ecole Polytechnique Federale De Lausanne (EPFL)Inventors: Nikolaos Stergiopulos, Constantinos Stergiopulos
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Publication number: 20230309910Abstract: Systems and methods for monitoring penile tumescence are provided that overcome the drawbacks of previously known systems by providing a wearable formed of a flexible and elastic tube having a plurality of sensors disposed on or embedded within it, the wearable configured to be applied to a penis of a subject, and a spaced-apart controller operatively coupled to retrieve data regarding circumferential and axial dimensional changes and penile rigidity from the plurality of sensors and transmit that data to an external computer or smartphone for analysis and display. The plurality of sensors may be coupled to the spaced-apart controller via a flexible lead or wirelessly using a passive RFID system.Type: ApplicationFiled: March 30, 2023Publication date: October 5, 2023Applicant: ECOLE POLYTECHNIQUE FEDERALE DE LAUSANNE (EPFL)Inventors: Rodrigo Araujo FRAGA DA SILVA, Nikolaos STERGIOPULOS, Chris Steven Braissant
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Patent number: 11712371Abstract: An ocular drainage system is provided for treating diseases that produce elevated intraocular pressures, such as glaucoma, wherein the system includes an implantable device and an external control unit, the implantable device includes a non-invasively adjustable valve featuring at least one deformable tube and a disk rotatably mounted within a housing, such that rotation of the disk using the external control unit causes the disk to apply a selected amount of compression to the deformable tube, thereby adjusting the fluidic resistance of the deformable tube and regulating the intraocular pressure.Type: GrantFiled: March 23, 2020Date of Patent: August 1, 2023Assignee: Ecole Polytechnique Federale De Lausanne (EPFL)Inventors: Stephane Bigler, Nikolaos Stergiopulos
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Publication number: 20220287640Abstract: Systems and methods are provided for that use noninvasively measured physiologic parameters to predict in real time noninvasively unobservable cardiovascular parameters by employing a one-dimensional arterial tree numerical model calibrated with representative patient data. The numerical model further may be trained and calibrated on a larger database that includes synthetic data using machine-learning algorithms to provide a robust generalized estimator for multiple cardiovascular and hemodynamic parameters.Type: ApplicationFiled: August 14, 2020Publication date: September 15, 2022Applicant: ECOLE POLYTECHNIQUE FEDERALE DE LAUSANNE (EPFL)Inventors: Vasiliki BIKIA, Stamatia PAGOULATOU, Nikolaos STERGIOPULOS
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Patent number: 11141590Abstract: An implantable stimulation system having an implantable stimulation unit coupled to a programmable controller, a stimulation circuit and an array of electrodes disposed on a pair of flexible paddles is provided for selectively stimulating at least one cavernous nerve. The programmable controller is pre-programmed to run an excitation electrode routine that selectively scans the electrode arrays on the paddles with a series of directional current flows, in at least two directions and within at least two regions, to optimize electrode selection for use in stimulating the cavernous nerve. The implantable stimulation system may be programmed to run a first stimulation pulse sequence corresponding to a first mode for invoking a rapid erectile response, and optionally, a second nerve rehabilitation stimulation mode selected to rehabilitate neural transmission in a cavernous nerve, and/or a third penile rehabilitation mode selected to reduce penile fibrosis. Methods of operating the system also are provided.Type: GrantFiled: February 11, 2021Date of Patent: October 12, 2021Assignee: Comphya SAInventors: Rodrigo Araujo Fraga Da Silva, Nikolaos Stergiopulos, Mikael Nils Sturny
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Patent number: 11141589Abstract: An implantable stimulation system having an implantable stimulation unit coupled to a programmable controller, a stimulation circuit and an array of electrodes disposed on a pair of flexible paddles is provided for selectively stimulating at least one cavernous nerve. The programmable controller is pre-programmed to run an excitation electrode routine that selectively scans the electrode arrays on the paddles with a series of directional current flows, in at least two directions and within at least two regions, to optimize electrode selection for use in stimulating the cavernous nerve. The implantable stimulation system may be programmed to run a first stimulation pulse sequence corresponding to a first mode for invoking a rapid erectile response, and optionally, a second nerve rehabilitation stimulation mode selected to rehabilitate neural transmission in a cavernous nerve, and/or a third penile rehabilitation mode selected to reduce penile fibrosis. Methods of operating the system also are provided.Type: GrantFiled: February 11, 2021Date of Patent: October 12, 2021Assignee: Comphya SAInventors: Rodrigo Araujo Fraga Da Silva, Nikolaos Stergiopulos, Mikael Nils Sturny
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Publication number: 20210275356Abstract: Apparatus and methods are provided for treating diseases that produce elevated intraocular pressures, such as glaucoma, wherein the device includes a housing shell defining a cavity between a first end and a second end of the housing shell, and an elastic membrane disposed within the cavity to divide the cavity into a fluidic channel that permits a flow of fluid from the first end to the second end and a sealed cavity. The elastic membrane deforms to change the volume of the sealed cavity responsive to pressure fluctuations between the first and second ends, thereby varying the fluidic resistance of the flow of fluid through the fluidic channel.Type: ApplicationFiled: March 1, 2021Publication date: September 9, 2021Applicant: Ecole Polytechnique Federale De Lausanne (EPFL)Inventors: Nikolaos STERGIOPULOS, Constantinos STERGIOPULOS
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Publication number: 20210196517Abstract: A device (100) is provided for treating diseases that produce elevated intraocular pressures, such as glaucoma, wherein the device (100) includes a housing shell (101) defining a cavity (107) between a first end (102) and a second end (104) of the housing shell (101), and an elastic membrane (110) disposed within the cavity (107) to divide the cavity (107) into a fluidic channel (106) that permits a flow of fluid from the first end (102) to the second (104) end and a sealed cavity (112). The elastic membrane (110) deforms to change the volume of the sealed cavity (107) responsive to pressure fluctuations between the first and second ends (102, 104), thereby varying the fluidic resistance of the flow of fluid through the fluidic channel (106).Type: ApplicationFiled: September 6, 2019Publication date: July 1, 2021Applicant: Ecole Polytechnique Federale De Lausanne (EPFL)Inventors: Nikolaos STERGIOPULOS, Constantinos STERGIOPULOS
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Publication number: 20200214891Abstract: An ocular drainage system is provided for treating diseases that produce elevated intraocular pressures, such as glaucoma, wherein the system includes an implantable device and an external control unit, the implantable device includes a non-invasively adjustable valve featuring at least one deformable tube and a disk rotatably mounted within a housing, such that rotation of the disk using the external control unit causes the disk to apply a selected amount of compression to the deformable tube, thereby adjusting the fluidic resistance of the deformable tube and regulating the intraocular pressure.Type: ApplicationFiled: March 23, 2020Publication date: July 9, 2020Applicant: ECOLE POLYTECHNIQUE FEDERALE DE LAUSANNE (EPFL)Inventors: Stephane BIGLER, Nikolaos STERGIOPULOS
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Patent number: 10603214Abstract: An ocular drainage system is provided for treating diseases that produce elevated intraocular pressures, such as glaucoma, wherein the system includes an implantable device and an external control unit, the implantable device includes a non-invasively adjustable valve featuring at least one deformable tube and a disk rotatably mounted within a housing, such that rotation of the disk using the external control unit causes the disk to apply a selected amount of compression to the deformable tube, thereby adjusting the fluidic resistance of the deformable tube and regulating the intraocular pressure.Type: GrantFiled: May 19, 2017Date of Patent: March 31, 2020Assignee: Ecole Polytechnique Federale De Lausanne (EPFL)Inventors: Stephane Bigler, Nikolaos Stergiopulos
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Patent number: 10596035Abstract: Apparatus and methods are provided for treating diseases that produce elevated intraocular pressures, such as glaucoma, wherein the device operates on the principles of a Starling resistor, and includes a housing, a deformable structure and a spring mounted within a housing, such that the spring applies a substantially constant spring force over a predetermined working range on the deformable structure to thereby self-regulate flow of fluid through the deformable structure.Type: GrantFiled: June 2, 2017Date of Patent: March 24, 2020Assignee: Ecole Polytechnique Federale De Lausanne (EPFL)Inventors: Nikolaos Stergiopulos, Constantinos Stergiopulos
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Patent number: 10300279Abstract: Systems and methods are provided for treating a sexual disorder such as erectile dysfunction (ED) or female sexual arousal disorder (FSAD). An electrical stimulation system may include an implantable stimulation unit, an external patient controller, and an external physician controller. The implantable stimulation unit has an array of electrodes disposed on one or more flexible substrates configured to conform to a patient's anatomy at the pelvic plexus. Post-implantation, the physician controller may direct the stimulation unit to stimulate with select electrode(s) of the array to determine which electrode configuration provides optimal sexual arousal. The patient controller may be used to cause the stimulation unit to stimulate using the optimal electrode configuration at desired times.Type: GrantFiled: October 25, 2017Date of Patent: May 28, 2019Assignee: Ecole Polytechnique Federale De Lausanne (EPFL)Inventors: Rodrigo Araujo Fraga {grave over (d)}a Silva, Nikolaos Stergiopulos
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Publication number: 20190134302Abstract: An implantable delivery device for delivering a fluid in a controlled manner, including a body having a chamber, a tube having an inlet and an outlet, at least a portion of the tube passing through the chamber, a drive pinion operatively connected to a motor for rotation, a wheel engaging with the drive pinion, and a ring operatively attached to the wheel, wherein the ring presses against the tube in a pressing zone and is driven by a rotation of the wheel relative to the body such that the pressing zone moves along the tube resulting from the rotation of the wheel to generate a movement of fluid present in the tube from the inlet to the outlet.Type: ApplicationFiled: November 8, 2018Publication date: May 9, 2019Inventors: Michel BACHMANN, Nikolaos STERGIOPULOS
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Publication number: 20180043164Abstract: Systems and methods are provided for treating a sexual disorder such as erectile dysfunction (ED) or female sexual arousal disorder (FSAD). An electrical stimulation system may include an implantable stimulation unit, an external patient controller, and an external physician controller. The implantable stimulation unit has an array of electrodes disposed on one or more flexible substrates configured to conform to a patient's anatomy at the pelvic plexus. Post-implantation, the physician controller may direct the stimulation unit to stimulate with select electrode(s) of the array to determine which electrode configuration provides optimal sexual arousal. The patient controller may be used to cause the stimulation unit to stimulate using the optimal electrode configuration at desired times.Type: ApplicationFiled: October 25, 2017Publication date: February 15, 2018Applicant: ECOLE POLYTECHNIQUE FEDERALE DE LAUSANNE (EPFL)Inventors: Rodrigo Araujo FRAGA DA SILVA, Nikolaos STERGIOPULOS
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Publication number: 20170348148Abstract: An ocular drainage system is provided for treating diseases that produce elevated intraocular pressures, such as glaucoma, wherein the system includes an implantable device and an external control unit, the implantable device includes a non-invasively adjustable valve featuring at least one deformable tube and a disk rotatably mounted within a housing, such that rotation of the disk using the external control unit causes the disk to apply a selected amount of compression to the deformable tube, thereby adjusting the fluidic resistance of the deformable tube and regulating the intraocular pressure.Type: ApplicationFiled: May 19, 2017Publication date: December 7, 2017Applicant: ÉCOLE POLYTECHNIQUE FÉDÉRALE DE LAUSANNEInventors: Stephane BIGLER, Nikolaos STERGIOPULOS
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Publication number: 20170348149Abstract: Apparatus and methods are provided for treating diseases that produce elevated intraocular pressures, such as glaucoma, wherein the device operates on the principles of a Starling resistor, and includes a housing, a deformable structure and a spring mounted within a housing, such that the spring applies a substantially constant spring force over a predetermined working range on the deformable structure to thereby self-regulate flow of fluid through the deformable structure.Type: ApplicationFiled: June 2, 2017Publication date: December 7, 2017Applicant: ÉCOLE POLYTECHNIQUE FÉDÉRALE DE LAUSANNEInventors: Nikolaos STERGIOPULOS, Constantinos STERGIOPULOS
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Patent number: 9821163Abstract: Systems and methods are provided for treating a sexual disorder such as erectile dysfunction (ED) or female sexual arousal disorder (FSAD). An electrical stimulation system may include an implantable stimulation unit, an external patient controller, and an external physician controller. The implantable stimulation unit has an array of electrodes disposed on one or more flexible substrates configured to conform to a patient's anatomy at the pelvic plexus. Post-implantation, the physician controller may direct the stimulation unit to stimulate with select electrode(s) of the array to determine which electrode configuration provides optimal sexual arousal. The patient controller may be used to cause the stimulation unit to stimulate using the optimal electrode configuration at desired times.Type: GrantFiled: October 12, 2015Date of Patent: November 21, 2017Assignee: Ecole Polytechnique Federal De Lausanne (EPFL)Inventors: Rodrigo Araujo Fraga Da Silva, Nikolaos Stergiopulos
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Patent number: 9655779Abstract: An ocular drainage system is provided for treating diseases that produce elevated intraocular pressures, such as glaucoma, wherein the system includes an implantable device and an external control unit. The implantable device includes a non-invasively adjustable valve featuring at least one deformable tube and a disk rotatably mounted within a housing, such that rotation of the disk using the external control unit causes the disk to apply a selected amount of compression to the deformable tube, thereby adjusting the fluidic resistance of the deformable tube and regulating the intraocular pressure.Type: GrantFiled: August 5, 2015Date of Patent: May 23, 2017Assignee: Ecole Polytechnique Federale De Lausanne (EPFL)Inventors: Stéphane Bigler, Nikolaos Stergiopulos