Patents by Inventor Nikolaus Muller

Nikolaus Muller has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Patent number: 6025499
    Abstract: Nitropyrazole amides of the formula (I) ##STR1## are prepared by reacting nitropyrazole esters of the formula (II) ##STR2## with ammonia.
    Type: Grant
    Filed: March 25, 1999
    Date of Patent: February 15, 2000
    Assignee: Bayer Aktiengesellschaft
    Inventors: Lutz Heuer, Nikolaus Muller, Guido Steffan
  • Patent number: 5977362
    Abstract: Quinazoline-2,4-diones are obtained in high yields and purities by reacting anthranilic acids with isocyanates and then, without isolation of the urea formed as intermediate, treating the reaction mixture with acid.
    Type: Grant
    Filed: May 26, 1998
    Date of Patent: November 2, 1999
    Assignee: Bayer Aktiengesellschaft
    Inventors: Nikolaus Muller, Klaus-Christian Paetz, Wolfgang Kiel
  • Patent number: 5977378
    Abstract: 1-alkyl-pyrazole-5-carboxylic acid esters are prepared by reacting the enolate of a 2,4-diketocarboxylic acid ester with an N-alkylhydrazinium salt in the presence of a solvent. This process allows a particularly economic preparation of 1-alkyl-pyrazole-5-carboxylic acid esters in a simple manner and with only little formation of undesirable isomers.
    Type: Grant
    Filed: January 8, 1998
    Date of Patent: November 2, 1999
    Assignee: Bayer Aktiengesellschaft
    Inventors: Nikolaus Muller, Lutz Heuer, Johannes Kanellakopoulos, Andreas Sattler, Klaus-Peter Heise
  • Patent number: 5969152
    Abstract: Nitropyrazole esters of the formula ##STR1## in which R.sup.1 represents C.sub.1 -C.sub.6 -alkyl, are prepared by nitration of the corresponding pyrazole esters. The nitropyrazole esters permit the preparation of a known nitropyrazole amide in a particularly simple and economical manner and thereby improve the preparation of active compounds which are accessible from the nitropyrazole amide.
    Type: Grant
    Filed: July 7, 1997
    Date of Patent: October 19, 1999
    Assignee: Bayer Aktiengesellschaft
    Inventors: Lutz Heuer, Nikolaus Muller, Guido Steffan
  • Patent number: 5885474
    Abstract: Leather can be pretreated to obtain good body, soft feel, and excellent grain smoothness and solidity with products having a molecular weight of 700 to 30,000 and which are obtainable by reaction ofA. polysuccinimide having a molecular weight, determined as the number-average, of 500 to 10,000, withB. 5 to 90 mol % based on the succinimide units of polysuccinimide A, and/or secondary amine, the nitrogen substituents of which contain 1 to 60 carbon atoms and which can be unsubstituted or substituted, at least 2.5 mol % of the nitrogen substituents of the amine containing at least 12 carbon atoms,C. optionally, (i) derivatives of C.sub.1 -C.sub.18 -monocarboxylic acids, C.sub.2 -C.sub.10 -dicarboxylic acids, and/or (ii) monoisocyanates, diisocyanates epichlorohydrin (for reaction of amino and/or hydroxyl groups on the nitrogen substituents of the reaction product of A and B), andD. 95 to 10 mol % of ring-opening base in the presence of water.
    Type: Grant
    Filed: January 28, 1998
    Date of Patent: March 23, 1999
    Assignee: Bayer Aktiengesellschaft
    Inventors: Jurgen Reiners, Manfred Schnee, Torsten Groth, Winfried Joentgen, Gerd Schmitz, Harro Traubel, Nikolaus Muller
  • Patent number: 5741937
    Abstract: Arylidene-substituted alkylcycloalkanones are prepared from alkyl-substituted cycloalkanones by reaction with aromatic carbonyl compounds in the presence of a basic catalyst and water.
    Type: Grant
    Filed: June 21, 1996
    Date of Patent: April 21, 1998
    Assignee: Bayer Aktiengesellschaft
    Inventors: Nikolaus Muller, Thomas Essert
  • Patent number: 5714558
    Abstract: Polyaspartic acid is prepared by polymerization of aspartic acid, maleic acid anhydride, maleic acid or fumaric acid in a solvent at from 130.degree. C. to 300.degree. C., optionally in the presence of ammonia.
    Type: Grant
    Filed: September 7, 1995
    Date of Patent: February 3, 1998
    Assignee: Bayer AG
    Inventors: Torsten Groth, Winfried Joentgen, Nikolaus Muller
  • Patent number: 5693831
    Abstract: The novel compound (2,3-dihydro-5-benzofuranyl)-acetonitrile is prepared by chloromethylating 2,3-dihydro-benzofuran and reacting the resulting 2,3-dihydro-5-chloromethyl-benzofuran with a cyanide. (2,3-Dihydro-5-benzofuranyl)-acetonitrile can be converted by saponification to (2,3-dihydro-5-benzofuranyl)-acetic acid, an important intermediate for the manufacture of various pharmaceutical active substances. This intermediate has hitherto been obtainable only by a laborious procedure and in low yields.
    Type: Grant
    Filed: February 27, 1997
    Date of Patent: December 2, 1997
    Assignee: Bayer Aktiengesellschaft
    Inventors: Nikolaus Muller, Guido Steffan
  • Patent number: 5679761
    Abstract: The polymers according to the invention with repeating succinyl units additionally contain iminodisuccinate units.
    Type: Grant
    Filed: August 15, 1995
    Date of Patent: October 21, 1997
    Assignee: Bayer AG
    Inventors: Lutz Heuer, Winfried Joentgen, Torsten Groth, Hans-Joachim Traenckner, Nikolaus Muller, Hermann Uhr, Klaus-Peter Heise, Karl-Hermann Brucher, Joachim-Reinhard Wesener, Ute Wollborn, Hans-Georg Pirkl, Thomas Menzel, Ulrich Liesenfelder, Paul Wagner
  • Patent number: 5672763
    Abstract: 2-Substituted cyclopentanones are prepared by reacting adipic ester with an alkoxide in the presence of an inert solvent, thus obtaining a salt of the cyclopentanone-2-carboxylic ester, alkylating this without isolation, thus obtaining a 2-alkyl-cyclopentanone-2-carboxylic ester and, without isolation, hydrolysing and decarboxylating this by treatment with an acid and heating.
    Type: Grant
    Filed: June 21, 1996
    Date of Patent: September 30, 1997
    Assignee: Bayer Aktiengesellschaft
    Inventors: Nikolaus Muller, Thomas Essert
  • Patent number: 5663447
    Abstract: A particularly advantageous process for the preparation of 2,2-dialkyl-arylidene-cycloalkanones is characterized in that 2-alkyl-arylidene-cycloalkanones are reacted with alkyl halides in the presence of metal hydroxides and tertiary alcohols.
    Type: Grant
    Filed: June 20, 1996
    Date of Patent: September 2, 1997
    Assignee: Bayer Aktiengesellschaft
    Inventors: Nikolaus Muller, Thomas Essert
  • Patent number: 5648517
    Abstract: A process has been found for the preparation of dialkyl maleates from maleic acid, maleic anhydride or monoalkyl maleates with C.sub.1 -C.sub.8 -alcohols, in particular ethanol, in the presence or absence of an acidic catalyst and at boiling heat, which is characterized in that the escaping water/alcohol/vapour mixture, together with its condensed phase if appropriate, is conducted as feed along a hydrophilic membrane at which it is purged of water and the dehydrated alcohol is returned to the reaction mixture.
    Type: Grant
    Filed: June 2, 1995
    Date of Patent: July 15, 1997
    Assignee: Bayer Aktiengesellschaft
    Inventors: Nikolaus Muller, Andreas Groschl, Ingo Janisch
  • Patent number: 5543490
    Abstract: Polyaspartic acid is prepared by reacting maleic anhydride and ammonia to give maleamic acid, polymerizing the maleamic acid and subsequently hydrolyzing the product to give polyaspartic acid or a salt thereof.
    Type: Grant
    Filed: December 17, 1993
    Date of Patent: August 6, 1996
    Assignee: Bayer AG
    Inventors: Torsten Groth, Winfried Joentgen, Hans W. Linden, Nikolaus Muller, Heinz-Joachim Rother, Paul Wagner, Martin Kugler
  • Patent number: 5401869
    Abstract: Aminomethylene compounds of the formula ##STR1## may advantageously be prepared by reacting C--H-acidic compounds of the formula ##STR2## with formamide acetals of the formula ##STR3## in which the radicals R.sup.1 to R.sup.6 have the meaning given in the description,if the process is carried out in the presence of a secondary amine of the formula ##STR4## in which R.sup.7 and R.sup.8 have the meaning given in the description.
    Type: Grant
    Filed: January 21, 1994
    Date of Patent: March 28, 1995
    Assignee: Bayer Aktiengesellschaft
    Inventors: Helmut Kraus, Nikolaus Muller, Gerhard Marzolph, Bernhard Beitzke
  • Patent number: 5326911
    Abstract: Ortho-amides of the formula ##STR1## can be prepared by reacting salts of the formula ##STR2## with alcoholates of the formulaM.sup.1 OR.sup.1 (III)where the radicals R.sup.1 to R.sup.4, M.sup.1 and X.sup..crclbar. have the meaning given in the description. The alcoholates are employed in highly active form with an effective content of 98-100% M.sup.1 OR.sup.1.
    Type: Grant
    Filed: July 20, 1992
    Date of Patent: July 5, 1994
    Assignee: Bayer Aktiengesellschaft
    Inventors: Heinz-Ulrich Blank, Helmut Kraus, Gerhard Marzolph, Nikolaus Muller
  • Patent number: 5236939
    Abstract: Substituted 1,3,4 -oxa- diazolinones of the formula (I) ##STR1## in which X represents O andY represents O or S,are disclosed as useful to combat endoparasites.
    Type: Grant
    Filed: October 17, 1991
    Date of Patent: August 17, 1993
    Assignee: Bayer Aktiengesellschaft
    Inventors: Gerhard Bonse, Nikolaus Muller, Achim Harder
  • Patent number: 5118680
    Abstract: A method of combating endoparasites in humans and animals which comprises administering to such humans and animals an endoparasiticidally effective amount of a 3-hydroxybenzothiophene of the formula ##STR1## in which X represents .dbd.CH-- or .dbd.N--,Y represents .dbd.O or .dbd.NH,R.sup.1 represents one or more identical or different radicals from the group consisting of hydrogen, alkyl, alkoxy, alkylthio, halogenoalkyl, halogenoalkoxy, halogenoalkylthio, alkylenedioxy, halogenoalkylenedioxy, halogen, CN, NO.sub.2, NH.sub.2, alkylamino, dialkylamino, alkylcarbonyl, carbalkoxy, alkylsulphonyl, arylsulphonyl, sulphamoyl, alkylsulphamoyl, dialkylsulphamoyl, aryl, aryloxy and arylthio, which, in turn, may again be substituted,R.sup.2 represents optionally substituted alkoxy, cycloalkoxy or the radical --NR.sup.3 R.sup.4,R.sup.3 represents hydrogen or alkyl,R.sup.4 represents an alkyl or carbocyclic or heterocyclic armoatic radical or the radical --COOR.sup.5,R.sup.3 and R.sup.
    Type: Grant
    Filed: June 20, 1991
    Date of Patent: June 2, 1992
    Assignee: Bayer Aktiengesellschaft
    Inventors: Nikolaus Muller, Werner Hallenbach, Achim Harder, Werner Lindner
  • Patent number: 5095024
    Abstract: Substituted 1,3,4-thiadiazolinones of the formula (I), ##STR1## in which X represents O or S,R.sup.1 represents hydrogen, alkyl, alkoxy, alkylthio, halogen, halogenoalkyl, halogenoalkoxy or halogenoalkylthio,R.sup.2 represents one or more identical or different radicals from the series comprising hydrogen, alkyl, alkoxy, alkylthio, halogenoalkyl, halogenoalkoxy, halogenoalkylthio, alkylenedioxy, halogenoalkylenedioxy, halogen, CN, NO.sub.2, NH.sub.2, alkylamino, dialkylamino, alkylcarbonyl, carbalkoxy, alkylsulphonyl, arylsulphonyl, sulphamoyl, alkylsulphamoyl, dialkylsulphamoyl, aryl, aryloxy and arylthio, each of which can, in turn, be substituted as well, andR.sup.3 represents alkyl, alkenyl or alkynyl, each of which can optionally be substituted,with the exception of the compound 5-methylmercapto-3-phenyl-1,3,4-thiadiazol-2-(3H)-one, are disclosed as being useful to combat endoparasites. Compositions containing these compounds, process for preparing them, and novel intermediates are also disclosed.
    Type: Grant
    Filed: September 13, 1990
    Date of Patent: March 10, 1992
    Assignee: Bayer Aktiengesellschaft
    Inventors: Nikolaus Muller, Gerhard Bonse, Werner Lindner, Achim Harder
  • Patent number: 5095032
    Abstract: Parasiticidal new substituted thienopyranones of the formula ##STR1## in which X represents O or S,R.sup.1 and R.sup.2 independently of one another represent hydrogen, halogen, CN, NO.sub.2, alkyl, aralkyl, aryl, alkylcarbonyl or alkoxycarbonyl, or, together with the adjacent C atoms, form a carbocyclic ring which is optionally interrupted by heteroatoms,R.sup.3 represents optionally substituted alkyl or phenyl,R.sup.4 represents hydrogen or alkyl,R.sup.3 and R.sup.4, together with the adjacent nitrogen atom, represent a heterocyclic 5- or 6-membered ring.Some of the intermediates for making them are also new.
    Type: Grant
    Filed: July 19, 1990
    Date of Patent: March 10, 1992
    Assignee: Bayer Aktiengesellschaft
    Inventors: Heinz-Jurgen Bertram, Nikolaus Muller, Achim Harder
  • Patent number: 5093343
    Abstract: Substituted 1,3,4-oxa- and thiadiazolinones of the formula (I) ##STR1## in which R.sup.1 represents hydrogen, alkyl, alkoxy, alkylthio, halogen, halogenoalkyl, halogenoalkoxy or halogenoalkylthio,R.sup.2 represents one or more identical or different radicals from among hydrogen, alkyl, alkoxy, alkylthio, halogenoalkyl, halogenoalkoxy, halogenoalkylthio, alkylenedioxy, halogenoalkylenedioxy, halogen, CN, NO.sub.2, NH.sub.2, alkylamino, dialkylamino, alkylcarbonyl, carbalkoxy, alkylsulphonyl, arylsulphonyl, sulphamoyl, alkylsulphamoyl, dialkylsulphamoyl, aryl, aryloxy or arylthio, which, in turn, can be sutstituted,R.sup.3 represents one or more identical or different radicals from among hydrogen, alkyl, alkoxy, alkylthio, halogenoalkyl, halogenoalkoxy, halogenoalkylthio, alkylenedioxy, halogenoalkylenedioxy, halogen, CN, NO.sub.
    Type: Grant
    Filed: September 5, 1990
    Date of Patent: March 3, 1992
    Assignee: Bayer Aktiengesellschaft
    Inventors: Gerhard Bonse, Nikolaus Muller, Achim Harder