Patents by Inventor Nikolaus Osterrieder

Nikolaus Osterrieder has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Patent number: 9555101
    Abstract: The present invention provides compositions or vaccines that contain a recombinant EHV-1 that elicit an immune response in animals against equine herpesvirus, including compositions comprising the recombinant EHV-1, methods of vaccination against equine herpesvirus, and kits for use with such methods and compositions.
    Type: Grant
    Filed: November 17, 2014
    Date of Patent: January 31, 2017
    Assignee: Merial, Inc.
    Inventors: Jean Christophe Audonnet, Jules Maarten Minke, Nikolaus Osterrieder, Guanggang Ma
  • Publication number: 20150190502
    Abstract: The present invention provides compositions or vaccines that contain a recombinant EHV-1 that elicit an immune response in animals against equine herpesvirus, including compositions comprising said recombinant EHV-1, methods of vaccination against equine herpesvirus, and kits for use with such methods and compositions.
    Type: Application
    Filed: November 17, 2014
    Publication date: July 9, 2015
    Applicant: MERIAL LIMITED
    Inventors: Jean Christophe Audonnet, Jules Maarten Minke, Nikolaus Osterrieder, Guanggang Ma
  • Patent number: 8916371
    Abstract: The present invention provides compositions or vaccines that contain a recombinant EHV-1 that elicit an immune response in animals against equine herpesvirus, including compositions comprising said recombinant EHV-1, methods of vaccination against equine herpesvirus, and kits for use with such methods and compositions.
    Type: Grant
    Filed: March 15, 2013
    Date of Patent: December 23, 2014
    Assignee: Merial Limited
    Inventors: Jean Christophe Audonnet, Jules Maarten Minke, Nikolaus Osterrieder, Guanggang Ma
  • Patent number: 8637046
    Abstract: The disclosure relates generally to the treatment or prevention of disease in cattle. More particularly, the invention is directed to the production and use of modified bovine herpesvirus 1 (BHV-1) and their use in compositions and vaccines that protect cattle from BHV-1 infection while not suppressing the immunological response in the host. In one example, the invention is directed to the use of modified BHV-1, administered with additional immunogens, either through co-administration and/or through administration in combination vaccines, and the use of these vaccines for the protection of cattle from disease. In one example, use of the modified BHV-1 in the administered compositions facilitates an immune response to or against the additional immunogens.
    Type: Grant
    Filed: October 1, 2009
    Date of Patent: January 28, 2014
    Assignees: Cornell University, Novartis AG
    Inventors: Nikolaus Osterrieder, Benedikt B. Kaufer, Gopinath Raju Seetharaman, Richard Harland, Lee David Albee, II, Mayur Navnitbhai Patel
  • Publication number: 20130251747
    Abstract: The present invention provides compositions or vaccines that contain a recombinant EHV-1 that elicit an immune response in animals against equine herpesvirus, including compositions comprising said recombinant EHV-1, methods of vaccination against equine herpesvirus, and kits for use with such methods and compositions.
    Type: Application
    Filed: March 15, 2013
    Publication date: September 26, 2013
    Applicants: FREIE UNIVERSIT√ĄT BERLIN, MERIAL LIMITED
    Inventors: Jean Christophe Audonnet, Jules Maarten Minke, Nikolaus Osterrieder, Guanggang Ma
  • Publication number: 20130195918
    Abstract: We have constructed a mutant EHV-1 that is lacking the entire 12.7 kbp IR segment of the viral genome and found the mutant EHV-1 to be replication competent, to have the ability to replicate in mammalian cell types (including human cells), and to exhibit reduced virulence in the mouse model of EHV-1 virulence.
    Type: Application
    Filed: August 2, 2012
    Publication date: August 1, 2013
    Inventors: Dennis J. O'Callaghan, ByungChul Ahn, Yunfei Zhang, Nikolaus Osterrieder
  • Publication number: 20120034262
    Abstract: The disclosure relates generally to the treatment or prevention of disease in cattle. More particularly, the invention is directed to the production and use of modified bovine herpesvirus 1 (BHV-1) and their use in compositions and vaccines that protect cattle from BHV-1 infection while not suppressing the immunological response in the host. In one example, the invention is directed to the use of modified BHV-1, administered with additional immunogens, either through co-administration and/or through administration in combination vaccines, and the use of these vaccines for the protection of cattle from disease. In one example, use of the modified BHV-1 in the administered compositions facilitates an immune response to or against the additional immunogens.
    Type: Application
    Filed: October 1, 2009
    Publication date: February 9, 2012
    Applicants: NOVARTIS AG, CORNELL UNIVERSITY
    Inventors: Nikolaus Osterrieder, Benedikt B. Kaufer, Gopinath Raju Seetharaman, Richard Harland, Lee David Albee, II, Mayur Navnitbhai Patel
  • Patent number: 8017317
    Abstract: This invention relates to Equine Herpes Viruses (EHV) wherein the protein gM is essentially absent or modified and non-functional with respect to its immunomodulatory capacity. Further aspects of the invention relate to nucleic acids coding said viruses, pharmaceutical compositions comprising these viruses or nucleic acids and uses thereof. The invention also relates to methods for improving the immune response induced by an EHV vaccine against wild type EHV infections, methods for the prophylaxis and treatment of EHV infections and methods for distinguishing wild type EHV infected animals from animals treated with EHV's according to the invention.
    Type: Grant
    Filed: December 17, 2007
    Date of Patent: September 13, 2011
    Assignee: Boehringer Ingelheim Vetmedica GmbH
    Inventors: Knut Elbers, Nikolaus Osterrieder, Christian Seyboldt
  • Publication number: 20110182865
    Abstract: Provided are compositions and methods for treatment and/or prophylaxis of EHV-I infections in horses. The compositions and methods effect treatment and/or prophylaxis of EHV-I infections through RNAi mediated inhibition of EHV-I gB and EHV-I Ori genes, which results in a reduction of the severity of neurological symptoms that are induced by EHV-I infection in horses, and/or a reduction in EHV-I viral shedding in the horses. Included are siRNAs or shRNAs that are designed to target EHV-I gB and EHV-I Ori helicase mRNAs. Also included are vectors encoding such shRNAs.
    Type: Application
    Filed: February 9, 2009
    Publication date: July 28, 2011
    Inventors: Nikolaus Osterrieder, Gerlinde Van De Walle, Sarah T. Peters
  • Patent number: 7482441
    Abstract: The invention belongs to the field of animal health, in particular equine diseases caused by equine herpesvirus (EHV). The invention relates to artificial chromosomes comprising the genome of equine herpesviruses, methods of producing attenuated or virulent EHV with or without the insertion of foreign genes, EHV obtainable with said methods and pharmaceutical compositions comprising said viruses.
    Type: Grant
    Filed: February 5, 2004
    Date of Patent: January 27, 2009
    Assignee: Boehringer Ingelheim Vetmedica GmbH
    Inventors: Nikolaus Osterrieder, Jens Rudolph
  • Patent number: 7309598
    Abstract: This invention relates to Equine Herpes Viruses (EHV) wherein the protein gM is essentially absent or modified and non-functional with respect to its immunomodulatory capacity. Further aspects of the invention relate to nucleic acids coding said viruses, pharmaceutical compositions comprising these viruses or nucleic acids and uses thereof. The invention also relates to methods for improving the immune response induced by an EHV vaccine against wild type EHV infections, methods for the prophylaxis and treatment of EHV infections and methods for distinguishing wild type EHV infected animals from animals treated with EHV's according to the invention.
    Type: Grant
    Filed: September 26, 2003
    Date of Patent: December 18, 2007
    Assignee: Boehringer Ingelheim Vetmedica GmbH
    Inventors: Knut Elbers, Nikolaus Osterrieder, Christian Seyboldt
  • Publication number: 20060160202
    Abstract: The invention belongs to the field of animal health, in particular equine diseases caused by equine herpesvirus (EHV). The invention relates to artificial chromosomes comprising the genome of equine herpesviruses, methods of producing attenuated or virulent EHV with or without the insertion of foreign genes, EHV obtainable with said methods and pharmaceutical compositions comprising said viruses.
    Type: Application
    Filed: February 5, 2004
    Publication date: July 20, 2006
    Applicant: Boehringer Ingelheim Vetmedica GmbH
    Inventors: Nikolaus Osterrieder, Jens Rudolph
  • Publication number: 20060110403
    Abstract: The present invention relates to animal viruses such as animal herpesviruses as a vector for diagnostic, therapeutic and prophylactic delivery of foreign genes and nucleic acids to animals, human or primary cells derived thereof, respectively. By using said viruses, the prevention and treatment of infectious, autoimmune and tumor diseases as well as allergies and genetic disorders can be treated. The present invention relates further to procedures to efficiently transduce primary human cells with recombinant animal viruses in vitro and in vivo. The invention further relates to a kit useful (i) for diagnosis and monitoring of innate and adoptive immune responses as well as (ii) for gene therapy and (iii) immunization purposes.
    Type: Application
    Filed: September 1, 2003
    Publication date: May 25, 2006
    Inventors: Martin Beer, Nikolaus Osterrieder, Jens Rudolph, Sascha Trapp, Ralf Wagner
  • Publication number: 20050084503
    Abstract: Provided is a method for producing a continuous cell line capable of supporting the growth of a Marek's disease virus (MDV) strain comprising infecting or transfecting a cell with a vector comprising a nucleic acid or fragment thereof of an MDV strain and culturing the cell or a progeny thereof under conditions suitable for the expression of the nucleic acid and propagation of the cell or progeny. The nucleic acid may comprise an MDV glycoprotein gE gene or functional fragment. Also provided is a method of generating, isolating, and/or maintaining a hypervirulent, very virulent, very virulent plus, virulent, and/or avirulent MDV strain comprising infecting a described cell with the MDV strain or strains, and culturing the cell under conditions suitable for the propagation of the cell and the generation, maintenance and isolation of the MDV strain or strains.
    Type: Application
    Filed: August 4, 2004
    Publication date: April 21, 2005
    Inventors: Nikolaus Osterrieder, Daniel Schumacher
  • Publication number: 20040063095
    Abstract: This invention relates to Equine Herpes Viruses (EHV) wherein the protein gM is essentially absent or modified and non-functional with respect to its immunomodulatory capacity. Further aspects of the invention relate to nucleic acids coding said viruses, pharmaceutical compositions comprising these viruses or nucleic acids and uses thereof. The invention also relates to methods for improving the immune response induced by an EHV vaccine against wild type EHV infections, methods for the prophylaxis and treatment of EHV infections and methods for distinguishing wild type EHV infected animals from animals treated with EHV's according to the invention.
    Type: Application
    Filed: September 26, 2003
    Publication date: April 1, 2004
    Applicant: Boehringer Ingelheim Vetmedica GmbH
    Inventors: Knut Elbers, Nikolaus Osterrieder, Christian Seyboldt
  • Patent number: 6703231
    Abstract: This invention relates to Equine Herpes Viruses (EHV) wherein the protein gM is essentially absent or modified and non-functional with respect to its immunomodulatory capacity. Further aspects of the invention relate to nucleic acids coding said viruses, pharmaceutical compositions comprising these viruses or nucleic acids and uses thereof. The invention also relates to methods for improving the immune response induced by an EHV vaccine against wild type EHV infections, methods for the prophylaxis and treatment of EHV infections and methods for distinguishing wild type EHV infected animals from animals treated with EHV's according to the invention.
    Type: Grant
    Filed: February 16, 2001
    Date of Patent: March 9, 2004
    Assignee: Boehringer Ingelheim Vetmedica GmbH
    Inventors: Knut Elbers, Nikolaus Osterrieder, Christian Seyboldt
  • Publication number: 20030198650
    Abstract: This invention relates to Equine Herpes Viruses (EHV) wherein the protein gM is essentially absent or modified and non-functional with respect to its immunomodulatory capacity. Further aspects of the invention relate to nucleic acids coding said viruses, pharmaceutical compositions comprising these viruses or nucleic acids and uses thereof. The invention also relates to methods for improving the immune response induced by an EHV vaccine against wild type EHV infections, methods for the prophylaxis and treatment of EHV infections and methods for distinguishing wild type EHV infected animals from animals treated with EHV's according to the invention.
    Type: Application
    Filed: February 16, 2001
    Publication date: October 23, 2003
    Inventors: Knut Elbers, Nikolaus Osterrieder, Christian Seyboldt
  • Publication number: 20030059934
    Abstract: The invention belongs to the field of animal health, in particular equine diseases caused by equine herpesvirus (EHV). The invention relates to artificial chromosomes comprising the genome of equine herpesviruses, methods of producing attenuated or virulent EHV with or without the insertion of foreign genes, EHV obtainable with said methods and pharmaceutical compositions comprising said viruses.
    Type: Application
    Filed: March 25, 2002
    Publication date: March 27, 2003
    Inventors: Nikolaus Osterrieder, Jens Rudolph