Abstract: The present invention provides systems, methods and software for improving robustness of transcriptomic data analysis, the method including receiving control cell transcriptomic data (C) and cell transcriptomic data (S) under study for a gene, calculating a fold change ratio (fc) for the gene, repeating these steps for a plurality of genes, grouping co-expressed genes into modules, estimating gene importance factors based on a network topology, mapped from a plurality of the modules and obtaining a insilico Pathway Activation Network Decomposition Analysis (iPANDA) value, wherein the iPANDA value has a Pearson coefficient greater than a Pearson coefficient associated with another platform for manipulating the same data.

Abstract: The present invention provides systems, methods and software predicting drug efficacy for treating a disorder in a patient, the method including providing a drug score database (DSD) based on pathway manifestation strengths (PMSs) for a plurality of biological pathways associated with the drug in the treatment of the disorder and comparing the pathway manifestation strengths of the plurality of biological pathways of the patient with the drug score database to provide a predictive indication if the patient is a responder or non-responder to the drug to determine whether the drug should be used in treating the patient.

Abstract: An apparatus and method are disclosed for monitoring outbound communications at a communication device, involving a monitoring module and a rule module. The monitoring module is configured to receive at least one indicator that an outbound text-based communication is queued for transmission from a communication device. The monitoring module is configured to receive at least one indicator produced in response to a request to establish an audio communication link between the communication device and a server. The rule module is in communication with the monitoring module. The rule module is configured to analyze a portion of the outbound text-based communication in response to the at least one indicator for the outbound text-based communication. The rule module is configured to analyze a portion of a signal associated with the audio communication link in response to the at least one indicator associated with the request.

Abstract: An apparatus and method for wireless device reconnection handling are disclosed involving a keep-alive request being sent from a wireless device to a server based on a first keep-alive time interval. At least one indicator that the keep-alive request has failed is received. A second keep-alive time interval different from the first keep-alive time interval is defined in response to at least one condition being satisfied and in response to the receiving. The defining includes defining the second keep-alive time interval when a response to the keep-alive request is not received from the server within a threshold time period associated with the at least one condition. In addition, the server is associated with a first wireless network. The first keep-alive time interval is defined before the sending based on a preference associated with a server associated with a second wireless network different than the first wireless network.