Patents by Inventor Nikolina D. Berova

Nikolina D. Berova has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Composition and method for treating glaucoma
    Patent number: 4923877
    Abstract: An antiglaucoma composition containing as the active component a s-/-/-2,3 dihydroxy-9,10,11-trimethoxy-5,8,13,13a-tetrahydro-6H-dibenzo (a,f) quinolizine hydrochloride of the general formula: ##STR1## where R.sub.1 .dbd.R.sub.2 .dbd.R.sub.3 .dbd.R.sub.4 .dbd.H.dbd.R.sub.5 .dbd.R.sub.6 .dbd.R.sub.7 .dbd.CH.sub.3 OThe composition is used as an ophthalmic solution in a method for treating glaucoma by administering a therapeutic dose of 2 to 3 drops two to four times daily to a host such as a warm-blooded animal having glaucoma.
    Type: Grant
    Filed: March 3, 1988
    Date of Patent: May 8, 1990
    Assignee: Pharmachim
    Inventors: Marko T. Markov, Chavdar B. Ivanov, Deltcho G. Jelyazkov, Diana M. Mondeschka, Nikolina D. Berova, Rositza S. Rakovska, Maria G. Todorova, Diana D. Popova, Emiliya D. Slavova, Tatyana S. Zikolova, Viola M. Marinova, Radi G. Ovcharov, Petko D. Uzunov, Jossif N. Nissimov, Dobrinka G. Gentcheva
  • Anti-ulcer composition
    Patent number: 4806548
    Abstract: This invention relates to an improved anti-ulcer composition for prophylaxis and treatment of stomach and duodenum ulcers, including stress ulcers. The composition provides potent anti-ulcer activity with a dramatic reduction in toxicity and harmful side effects. The composition comprises a histamine H.sub.2 antagonist based on a guanidine derivative, preferably [N-cyano-H'-methyl-N"]-2(4-methyl-imidazolyl)-methylthio-[ethylguanidine]; and at least one 4-phenyl-tetrahydroisoquinoline antidepressant, preferably the [+] isomer of 4-phenyl-2-methyl-8-amino-1,2,3,4-tetrahydroisoquinoline hydrogen maleate. The composition may also contain a spasmolytic agent, preferably 2-metoxycarbonyl-4-(beta-piperidino ethyl) -metoxycarbonyl-4-(beta-peperidinoethyl) benzophenone. The ratio of antagonist to antidepressant ranges from 2:1 to 60:1, and the ratio of their sum to the spasmolytic agent, when used, ranges from 2.2:1 to 42.5:1.
    Type: Grant
    Filed: August 4, 1987
    Date of Patent: February 21, 1989
    Assignee: T P O Pharmachim
    Inventors: Nedyalka S. Ivanova, Tshavdar B. Ivanov, Margarita D. Dryanska, Orhideya B. Zabunova, Lilyana D. Dalleva, Milka P. Nikolova, Nikolina D. Berova, Rossitza S. Rakovska, Maria S. Stoyanova, Sascha R. Mihaylova, Milka A. Luna, Jossif N. Nissimou, Snejana G. Vitkova, Vladimir K. Matov, Boris K. Dimitrov, Grigor M. Metshkov
  • 1-(3,4-dimethylbenzyl)-2-(N-alkyl)-carbamoyl tetrahydroiso quinolines
    Patent number: 4678853
    Abstract: Compounds of the Formula (I) ##STR1## wherein R.sub.1 and R.sub.2 are hydroxyl or methoxyl; R.sub.3 is hydrogen or methoxyl; and R.sub.4 is methyl or chloroethyl; are disclosed having the ability to inhibit adenylatecyclase.
    Type: Grant
    Filed: January 13, 1986
    Date of Patent: July 7, 1987
    Assignee: T P O "Pharmachim"
    Inventors: Chavdar B. Ivanov, Donka M. Mondeshka, Nikolina D. Berova, Rossitza S. Rakovska, Yordanka T. Panova, Marko T. Markov, Radi G. Ovcharov, Petko D. Usunov, Orhideya B. Zabunova