Abstract: A method of managing a transaction in a control plane executing on a computing system that manages a plurality of services includes: receiving, at the control plane from a client, a plurality of first requests for at least one target service of the plurality of services, each of the plurality of first requests including a transaction indicator identifying the transaction; executing at least one handler of the at least one target service to process the plurality of first requests; receiving, at the control plane from the client, a commit request for the transaction coordinator service, the commit request including an instruction to commit the transaction; and executing a handler of the transaction coordinator service to process the commit request and notify the at least one target service of a status of the commit request.

Abstract: The present invention provides compositions and methods for detecting, analyzing, and identifying biomolecules used to diagnose patient with risk of DHF. More particularly, the invention provides plasma biomarkers including complement factor D to complement factor H (FactorD/FactorH) ratio and levels of one or more of IL2, desmoplakin, and high molecular weight albumin, which are used to detect risk of developing DHF.

Abstract: A method of managing a transaction in a control plane executing on a computing system that manages a plurality of services includes: receiving, at the control plane from a client, a plurality of first requests for at least one target service of the plurality of services, each of the plurality of first requests including a transaction indicator identifying the transaction; executing at least one handler of the at least one target service to process the plurality of first requests; receiving, at the control plane from the client, a commit request for the transaction coordinator service, the commit request including an instruction to commit the transaction; and executing a handler of the transaction coordinator service to process the commit request and notify the at least one target service of a status of the commit request.

Abstract: The present invention provides compositions and methods for detecting, analyzing, and identifying biomolecules used to diagnose patient with risk of DHF. More particularly, the invention provides plasma biomarkers including complement factor D to complement factor H (FactorD/FactorH) ratio and levels of one or more of IL2, desmoplakin, and high molecular weight albumin, which are used to detect risk of developing DHF.

Abstract: The invention generally relates to recombinant polynucleotides, positive-strand RNA virus (psRNAV) recombinant expression vectors, and packaging systems. The packaging systems are based on the expression of helper functions by coinfecting recombinant poxvirus vectors comprising recombinant polynucleotides. Methods for obtaining psRNAV replicon particles using these packaging systems are disclosed. Immunogenic compositions and pharmaceutical formulations are provided that comprise replicon particles of the invention. Methods for generating an immune response or producing a pharmaceutical effect are also provided.

Abstract: The invention generally relates to recombinant polynucleotides, positive-strand RNA virus (psRNAV) recombinant expression vectors, and packaging systems. The packaging systems are based on the expression of helper functions by coinfecting re-combinant poxvirus vectors comprising recombinant polynucleotides. Methods for obtaining psRNAV replicon particles using these packaging systems are disclosed. Immunogenic compositions and pharmaceutical formulations are provided that comprise replicon particles of the invention. Methods for generating an immune response or producing a pharmaceutical effect are also provided.