Abstract: Methods and systems for calibrating a medical imaging system based on visual feedback are described. A method includes projecting one or more points of a target area (real world) of the medical imaging system as an overlay on the feedback frame, wherein the feedback frame is an image of the target area captured by an imaging device of a visual feedback system. One or more points of the target area are then located on the feedback frame. Further, the method includes improving calibration accuracy of the medical imaging system by minimizing difference between one or more projected points and one or more point located on the feedback frame below a predefined threshold. The difference is minimized via an iterative error correction mechanism.