Abstract: A tissue connector may include a body formed of one or more layers of material, and at least one barbed suture attached to the body, wherein the barbed suture is formed of a biodegradable material. A method of forming a tissue connector may include forming a body from one or more layers of a material, and attaching at least one barbed suture to the body, wherein the barbed suture is formed of a biodegradable material. A method of repairing tissue using a tissue connector may include orienting the tissue connector around coapted or damaged tissue, so that the coapted or damaged tissue contacts the inner surface of the tissue connector, twisting ends of the at least one barbed suture so that the at least one barbed suture engages the coapted or damaged tissue, and allowing the tissue connector to remain in place, so that the barbed suture degrades over time.

Abstract: Described herein are targeted ChABC fusion proteins, complexes thereof, and uses thereof. The targeted ChABC fusion proteins can include a ChABC polypeptide that can be linked to a Gal-3 polypeptide. Monomer targeted ChABC fusion proteins can form homogeneous or heterogeneous complexes. The targeted ChABC fusion proteins and complexes thereof can be formulated as pharmaceutical formulations. The targeted ChABC fusion proteins, complexes thereof, and formulations thereof can be administered to a subject in need thereof.