Patents by Inventor Niles Fleischer
Niles Fleischer has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Patent number: 11594757Abstract: Electrolytes, anodes, lithium ion cells and methods are provided for preventing lithium metallization in lithium ion batteries to enhance their safety. Electrolytes comprise up to 20% ionic liquid additives which form a mobile solid electrolyte interface during charging of the cell and prevent lithium metallization and electrolyte decomposition on the anode while maintaining the lithium ion mobility at a level which enables fast charging of the batteries. Anodes are typically metalloid-based, for example include silicon, germanium, tin and/or aluminum. A surface layer on the anode bonds, at least some of the ionic liquid additive to form an immobilized layer that provides further protection at the interface between the anode and the electrolyte, prevents metallization of lithium on the former and decomposition of the latter.Type: GrantFiled: March 2, 2017Date of Patent: February 28, 2023Assignee: STOREDOT LTD.Inventors: Doron Burshtain, Eran Sella, Niles Fleischer, Hani Farran, Leora Shapiro
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Patent number: 11541170Abstract: The present application provides a self-powered drug-delivery device. The device includes a chamber having a wall. The chamber contains a fluid and is in connection with an administration means. The device also includes a displacement-generating battery cell. The device further includes an electrically-controlled battery unit, which includes the displacement-generating battery cell coupled to the chamber by a coupling means. The displacement-generating battery cell includes an element that changes shape as a result of charge or discharge of the battery cell so as to cause a displacement within the battery unit. The arrangement of the battery unit, the coupling means, the wall, the chamber, and the administration means is such that the displacement derived from the battery unit is conveyed by the coupling means to cause displacement of the wall of the chamber such that the fluid is expelled from the chamber to force a drug towards the administration means.Type: GrantFiled: August 6, 2020Date of Patent: January 3, 2023Assignee: United Therapeutics CorporationInventors: Amir Genosar, Doron Aurbach, Elena Markevich, Grigory Salitra, Jonathan Goldstein, Mikhail Levi, Niles Fleischer, Yehuda Bachar, Yossi Aldar
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Publication number: 20200375516Abstract: A displacement-generating battery cell for driving a drug-delivery device is described. The cell may include at least one volume-changing element. The cell may include a housing formed according to a concertina-shaped design with folds in the walls thereof and may contain an internal chemical reaction system. The chemical reaction system may include an electrode. The electrode may be the volume-changing element. The arrangement of said chemical reaction system may be such that an expansion of the volume-changing element in a direction lengthens the cell and thus reduces the extent of the folds. Drug-delivery devices including the displacement-generating battery cell are also described.Type: ApplicationFiled: August 21, 2020Publication date: December 3, 2020Inventors: Jonathan Goldstein, Niles Fleischer, Nir Rotem, Lior Bar-Gat, Vladimir Piskosh
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Publication number: 20200368425Abstract: The present application provides a self-powered drug-delivery device. The device includes a chamber having a wall. The chamber contains a fluid and is in connection with an administration means. The device also includes a displacement-generating battery cell. The device further includes an electrically-controlled battery unit, which includes the displacement-generating battery cell coupled to the chamber by a coupling means. The displacement-generating battery cell includes an element that changes shape as a result of charge or discharge of the battery cell so as to cause a displacement within the battery unit. The arrangement of the battery unit, the coupling means, the wall, the chamber, and the administration means is such that the displacement derived from the battery unit is conveyed by the coupling means to cause displacement of the wall of the chamber such that the fluid is expelled from the chamber to force a drug towards the administration means.Type: ApplicationFiled: August 6, 2020Publication date: November 26, 2020Applicant: SteadyMed Ltd.Inventors: Amir Genosar, Doron Aurbach, Elena Markevich, Grigory Salitra, Jonathan Goldstein, Mikhail Levi, Niles Fleischer, Yehuda Bachar, Yossi Aldar
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Patent number: 10750987Abstract: Embodiments of the present invention provide drug-delivery devices comprising a drug reservoir chamber containing a substance to be delivered, in fluid connection with a drug administration means, and at least one displacement-generating battery cell coupled to said drug reservoir chamber by a coupling means, the at least one displacement-generating battery cell comprising an element that changes shape as a result of discharge of the battery cell so as to cause a displacement within the battery unit, the arrangement being such that the displacement derived from said battery unit is conveyed by said coupling means to cause displacement of at least a portion of a wall of said drug reservoir chamber reducing the volume of said drug reservoir chamber such that said substance is expelled from said drug reservoir chamber towards said drug administration means upon discharge, thereby being a self-powered drug delivery device.Type: GrantFiled: June 27, 2017Date of Patent: August 25, 2020Assignee: SteadyMed Ltd.Inventors: Jonathan Goldstein, Niles Fleischer, Nir Rotem, Lior Bar-Gat, Vladimir Piskosh
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Patent number: 10737017Abstract: The present application provides a self-powered drug-delivery device. The device includes a chamber having a wall. The chamber contains a fluid and is in connection with an administration means. The device also includes a displacement-generating battery cell. The device further includes an electrically-controlled battery unit, which includes the displacement-generating battery cell coupled to the chamber by a coupling means. The displacement-generating battery cell includes an element that changes shape as a result of charge or discharge of the battery cell so as to cause a displacement within the battery unit. The arrangement of the battery unit, the coupling means, the wall, the chamber, and the administration means is such that the displacement derived from the battery unit is conveyed by the coupling means to cause displacement of the wall of the chamber such that the fluid is expelled from the chamber to force a drug towards the administration means.Type: GrantFiled: May 7, 2018Date of Patent: August 11, 2020Assignee: SteadyMed Ltd.Inventors: Amir Genosar, Doron Aurbach, Elena Markevich, Grigory Salitra, Jonathan Goldstein, Mikhail Levi, Niles Fleischer, Yehuda Bachar, Yossi Aldar
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Patent number: 10302703Abstract: Method and system for monitoring the safety of a rechargeable Li-ion battery (LIB). An initial electrical state of the LIB is determined and altered by application or removal of DC electrical stimulus to trigger a time-varying response. The time-varying response of the LIB is measured, and at least one primary response parameter associated with the functional form of the measured response is extracted. At least one secondary response parameter is derived from the primary response parameter. A composite response parameter may be further derived from the primary response parameter and secondary response parameter. A likelihood of a short circuit precursor condition is determined in accordance with the primary response parameter, secondary response parameter and/or composite response parameter. Based on the determined likelihood, an alert of a potential short circuit derived hazard may be provided and/or a corrective measure to mitigate or prevent a short circuit derived hazard may be implemented.Type: GrantFiled: July 6, 2016Date of Patent: May 28, 2019Assignee: Algolion Ltd.Inventors: Niles Fleischer, Alex Nimberger
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Publication number: 20180250465Abstract: The present application provides a self-powered drug-delivery device. The device includes a chamber having a wall. The chamber contains a fluid and is in connection with an administration means. The device also includes a displacement-generating battery cell. The device further includes an electrically-controlled battery unit, which includes the displacement-generating battery cell coupled to the chamber by a coupling means. The displacement-generating battery cell includes an element that changes shape as a result of charge or discharge of the battery cell so as to cause a displacement within the battery unit. The arrangement of the battery unit, the coupling means, the wall, the chamber, and the administration means is such that the displacement derived from the battery unit is conveyed by the coupling means to cause displacement of the wall of the chamber such that the fluid is expelled from the chamber to force a drug towards the administration means.Type: ApplicationFiled: May 7, 2018Publication date: September 6, 2018Applicant: SteadyMed Ltd.Inventors: Amir Genosar, Doron Aurbach, Elena Markevich, Grigory Salitra, Jonathan Goldstein, Mikhail Levi, Niles Fleischer, Yehuda Bachar, Yossi Aldar
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Publication number: 20180196107Abstract: Method and system for monitoring the safety of a rechargeable Li-ion battery (LIB). An initial electrical state of the LIB is determined and altered by application or removal of DC electrical stimulus to trigger a time-varying response. The time-varying response of the LIB is measured, and at least one primary response parameter associated with the functional form of the measured response is extracted. At least one secondary response parameter is derived from the primary response parameter. A composite response parameter may be further derived from the primary response parameter and secondary response parameter. A likelihood of a short circuit precursor condition is determined in accordance with the primary response parameter, secondary response parameter and/or composite response parameter. Based on the determined likelihood, an alert of a potential short circuit derived hazard may be provided and/or a corrective measure to mitigate or prevent a short circuit derived hazard may be implemented.Type: ApplicationFiled: July 6, 2016Publication date: July 12, 2018Applicant: ALGOLION LTD.Inventors: Niles FLEISCHER, Alex NIMBERGER
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Patent number: 10010671Abstract: Embodiments include a displacement-generating battery cell for driving a drug-delivery device. The cell includes at least one volume-changing element. The cell also includes a housing formed according to a concertina-shaped design with folds in the walls thereof and containing an internal chemical reaction system. The arrangement of the chemical reaction system is such that as the cell is discharged, the volume-changing element expands, thereby lengthening the battery and thus reducing the extent of said folds, such that the cell becomes taller to reflect the expansion of the volume-changing component.Type: GrantFiled: August 11, 2014Date of Patent: July 3, 2018Assignee: STEADYMED LTD.Inventors: Amir Genosar, Doron Aurbach, Elena Markevich, Grigory Salitra, Jonathan Goldstein, Mikhail Levi, Niles Fleischer, Yehuda Bachar, Yossi Aldar
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Publication number: 20180035935Abstract: Embodiments of the present invention provide drug-delivery devices comprising a drug reservoir chamber containing a substance to be delivered, in fluid connection with a drug administration means, and at least one displacement-generating battery cell coupled to said drug reservoir chamber by a coupling means, the at least one displacement-generating battery cell comprising an element that changes shape as a result of discharge of the battery cell so as to cause a displacement within the battery unit, the arrangement being such that the displacement derived from said battery unit is conveyed by said coupling means to cause displacement of at least a portion of a wall of said drug reservoir chamber reducing the volume of said drug reservoir chamber such that said substance is expelled from said drug reservoir chamber towards said drug administration means upon discharge, thereby being a self-powered drug delivery device.Type: ApplicationFiled: June 27, 2017Publication date: February 8, 2018Inventors: Jonathan Goldstein, Niles Fleischer, Nir Rotem, Lior Bar-Gat, Vladimir Piskosh
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Publication number: 20170294680Abstract: Electrolytes, anodes, lithium ion cells and methods are provided for preventing lithium metallization in lithium ion batteries to enhance their safety. Electrolytes comprise up to 20% ionic liquid additives which form a mobile solid electrolyte interface during charging of the cell and prevent lithium metallization and electrolyte decomposition on the anode while maintaining the lithium ion mobility at a level which enables fast charging of the batteries. Anodes are typically metalloid-based, for example include silicon, germanium, tin and/or aluminum. A surface layer on the anode bonds, at least some of the ionic liquid additive to form an immobilized layer that provides further protection at the interface between the anode and the electrolyte, prevents metallization of lithium on the former and decomposition of the latter.Type: ApplicationFiled: March 2, 2017Publication date: October 12, 2017Inventors: Doron BURSHTAIN, Eran SELLA, Niles FLEISCHER, Hani FARRAN, Leora SHAPIRO
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Patent number: 9687186Abstract: Embodiments of the present invention provide drug-delivery devices comprising a drug reservoir chamber containing a substance to be delivered, in fluid connection with a drug administration means, and at least one displacement-generating battery cell coupled to said drug reservoir chamber by a coupling means, the at least one displacement-generating battery cell comprising an element that changes shape as a result of discharge of the battery cell so as to cause a displacement within the battery unit, the arrangement being such that the displacement derived from said battery unit is conveyed by said coupling means to cause displacement of at least a portion of a wall of said drug reservoir chamber reducing the volume of said drug reservoir chamber such that said substance is expelled from said drug reservoir chamber towards said drug administration means upon discharge, thereby being a self-powered drug delivery device.Type: GrantFiled: August 1, 2013Date of Patent: June 27, 2017Assignee: STEADYMED LTD.Inventors: Jonathan Goldstein, Niles Fleischer, Nir Rotem, Lior Bar-Gat, Vladimir Piskosh
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Publication number: 20150017493Abstract: The present application provides a drug-delivery device comprising a drug reservoir chamber 16, containing a substance to be delivered, in fluid connection with a drug administration means 18, and an electrically-controlled battery unit 10 comprising at least one displacement-generating battery cell 19 coupled to the drug reservoir chamber 16 by a coupling means 14, the arrangement being such that the displacement derived from the battery unit 10 is conveyed by the coupling means 14 to the drug reservoir chamber 16 such that the substance is expelled from the drug reservoir chamber 16 towards the drug administration means 18.Type: ApplicationFiled: August 11, 2014Publication date: January 15, 2015Inventors: Amir Genosar, Doron Aurbach, Elena Markevich, Grigory Salitra, Jonathan Goldstein, Mikhail Levi, Niles Fleischer, Yehuda Bachar, Yossi Aldar
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Patent number: 8834454Abstract: The present application provides a drug-delivery device comprising a drug reservoir chamber 16, containing a substance to be delivered, in fluid connection with a drug administration means 18, and an electrically-controlled battery unit 10 comprising at least one displacement-generating battery cell 19 coupled to the drug reservoir chamber 16 by a coupling means 14, the arrangement being such that the displacement derived from the battery unit 10 is conveyed by the coupling means 14 to the drug reservoir chamber 16 such that the substance is expelled from the drug reservoir chamber 16 towards the drug administration means 18.Type: GrantFiled: May 6, 2007Date of Patent: September 16, 2014Assignee: SteadyMed Ltd.Inventors: Amir Genosar, Doron Aurbach, Elena Markevich, Grigory Salitra, Jonathan Goldstein, Mikhail Levi, Niles Fleischer, Yehuda Bachar, Yossi Aldar
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Publication number: 20140163339Abstract: Embodiments of the present invention provide drug-delivery devices comprising a drug reservoir chamber containing a substance to be delivered, in fluid connection with a drug administration means, and at least one displacement-generating battery cell coupled to said drug reservoir chamber by a coupling means, the at least one displacement-generating battery cell comprising an element that changes shape as a result of discharge of the battery cell so as to cause a displacement within the battery unit, the arrangement being such that the displacement derived from said battery unit is conveyed by said coupling means to cause displacement of at least a portion of a wall of said drug reservoir chamber reducing the volume of said drug reservoir chamber such that said substance is expelled from said drug reservoir chamber towards said drug administration means upon discharge, thereby being a self-powered drug delivery device.Type: ApplicationFiled: August 1, 2013Publication date: June 12, 2014Applicant: STEADYMED LTD.Inventors: Jonathan Goldstein, Niles Fleischer, Nir Rotem, Lior Bar-Gat, Vladimir Piskosh
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Patent number: 7927736Abstract: Apparatus and methodology subject matters relate to an improved electrochemical single or multi-cell energy storage device. Also, an outer casing may be provided as a pair of U-shaped shells, a single foil piece, or a tube-shaped structure which encases the internal electro chemical cell stack. The energy storage device and such casing when used advantageously exhibit low internal resistance, low ESR, a high voltage/capacity, and a low contact resistance between the internal stack and the outer casing.Type: GrantFiled: November 4, 2009Date of Patent: April 19, 2011Assignee: E.C.R.-Electro Chemical Research Ltd.Inventors: Arieh Meitav, Joel Lang, Niles Fleischer, David Lifschitz, Eugene Pecherer, Eli Rosh Chodesh, Joost Manassen, Bharat Rawal
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Patent number: 7687198Abstract: Apparatus and methodology subject matters relate to an improved electrochemical single or multi-cell energy storage device. Also, an outer casing may be provided as a pair of U-shaped shells, a single foil piece, or a tube-shaped structure which encases the internal electrochemical cell stack. The energy storage device and such casing when used advantageously exhibit low internal resistance, low ESR, a high voltage/capacity, and a low contact resistance between the internal stack and the outer casing.Type: GrantFiled: October 31, 2007Date of Patent: March 30, 2010Assignee: E.C.R.-Electro Chemical Research Ltd.Inventors: Arieh Meitav, Joel Lang, Niles Fleischer, David Lifschitz, Eugene Pecherer, Eli Rosh Chodesh, Joost Manassen, Bharat Rawal
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Publication number: 20100047683Abstract: Apparatus and methodology subject matters relate to an improved electrochemical single or multi-cell energy storage device. Also, an outer casing may be provided as a pair of U-shaped shells, a single foil piece, or a tube-shaped structure which encases the internal electro chemical cell stack. The energy storage device and such casing when used advantageously exhibit low internal resistance, low ESR, a high voltage/capacity, and a low contact resistance between the internal stack and the outer casing.Type: ApplicationFiled: November 4, 2009Publication date: February 25, 2010Applicant: E.C.R.-ELECTRO CHEMICAL RESEARCH, LTD.Inventors: Arieh Meitav, Joel Lang, Niles Fleischer, David Lifschitz, Eugene Pecherer, Eli Rosh Chodesh, Joost Manassen, Bharat Rawal
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Publication number: 20100022992Abstract: The present application provides a drug-delivery device comprising a drug reservoir chamber 16, containing a substance to be delivered, in fluid connection with a drug administration means 18, and an electrically-controlled battery unit 10 comprising at least one displacement-generating battery cell 19 coupled to the drug reservoir chamber 16 by a coupling means 14, the arrangement being such that the displacement derived from the battery unit 10 is conveyed by the coupling means 14 to the drug reservoir chamber 16 such that the substance is expelled from the drug reservoir chamber 16 towards the drug administration means 18.Type: ApplicationFiled: May 6, 2007Publication date: January 28, 2010Applicant: STEADYMED.LTDInventors: Amir Genosar, Doron Aurbach, Elena Markevich, Grigory Salitra, Jonothan Goldstein, Mikhail Levi, Niles Fleischer, Yehuda Bachar, Yossi Aldar