Abstract: Described are a group of isoxazol-3(2H)-one analogues and their use in topical formulations for the treatment and prophylaxis of dermatological disorders.

Abstract: Described are a group of isoxazol-3(2H)-one analogues and their use in topical formulations for the treatment and prophylaxis of dermatological disorders.

Abstract: Pharmaceutical preparation containing an effective amount of acetylsalicylic acid and a compound of Formula I. A1—A2—NH—(CH2)n—B wherein A1, A2, n and B are as defined in the specification, which is either the compound as such, or a stereoisomer thereof, and which may be in the form of a physiologically acceptable salt, in association with a pharmaceutical carrier. The combinations are suitable for use in inhibiting thrombin, or in the treatment or prophylaxis of thrombosis or hypercoagulability in patients in need thereof.

Abstract: The invention relates to new competitive tripeptide inhibitors of trypsin-like serine proteases, their synthesis, pharmaceutical compositions containing the compounds as active ingredients, and the use of the compounds as thrombin inhibitors, anticoagulants and antiinflammatory inhibitors for prophylaxis and treatment of related diseases.

Abstract: The invention relates to compounds of the formulaA.sup.1 --A.sup.2 --NH--(CH.sub.2).sub.n --B Formula IandA.sup.1 --A.sup.2 --NH--(CH.sub.2).sub.n --B--D Formula Vas well as stereoisomers and physiologically acceptable salts thereof which act as competitive inhibitors of trypsin-like serine proteases, particularly kininogenases. The invention further relates to pharmaceutical compositions containing the compounds as active ingredients and the use of the compounds as kininogenase inhibitors and in the treatment of diseases related to kinin formation.

Abstract: A method is disclosed for treatment or prophylaxis of venous thrombosis employing the peptide HOOC--CH.sub.2 --(R)Cgl--aze--Pab or a stereoisomer thereof or a physiologically acceptable salt thereof.

Abstract: The invention concerns the compounds of the formulas: ##STR1## and protected forms and salts thereof which serve as starting materials in an improved method of synthesizing serine protease inhibitors. The invention further concerns an improved method for synthesizing serine protease inhibitors which utilizes the compounds.

Abstract: The invention concerns the compounds of the formulas: ##STR1## and protected forms and salts thereof which serve as starting materials in an improved method of synthesizing thrombin and kininogenase inhibitors. The invention further concerns an improved method for synthesizing the inhibitors which utilizes the compounds.