Patents by Inventor Nils Griebenow
Nils Griebenow has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
-
Publication number: 20200377486Abstract: The present invention covers quinoline compounds of general formula (I), in which A, R1, R2, R3, R4, R5, R6, and Q are as defined herein, methods of preparing said compounds, intermediate compounds useful for preparing said compounds, pharmaceutical compositions and combinations comprising said compounds and the use of said compounds for manufacturing pharmaceutical compositions for the treatment, control and/or prevention of diseases, in particular of helminth infections, as a sole agent or in combination with other active ingredients.Type: ApplicationFiled: July 30, 2018Publication date: December 3, 2020Applicant: Bayer Animal Health GMBHInventors: Nils GRIEBENOW, Wei ZHUANG, Daniel KULKE, Claudia BÖHM, Hans-Georg SCHWARZ, Walter HÜBSCH, Thomas ILG
-
Publication number: 20200299299Abstract: The present invention covers Pyrazolopyrimidine compounds of general formula (I): in which n, o, X, Y, R, Q, R1, R2, R3 and R4 are as defined herein, methods of preparing said compounds, intermediate compounds useful for preparing said compounds, pharmaceutical compositions and combinations comprising said compounds and the use of said compounds for manufacturing pharmaceutical compositions for the treatment, control and/or prevention of diseases, in particular of helminth infections, as a sole agent or in combination with other active ingredients.Type: ApplicationFiled: January 29, 2020Publication date: September 24, 2020Applicant: BAYER ANIMAL HEALTH GMBHInventors: Hans-Georg SCHWARZ, Adeline KÖHLER, Nils GRIEBENOW, Wei ZHUANG
-
Publication number: 20200261461Abstract: The present application relates to the use of fused heteroaromatic pyrrolidones for treatment and/or prophylaxis of allergic and/or inflammatory diseases in animals and to the use thereof for production of medicaments for treatment and/or prophylaxis of allergic and/or inflammatory diseases in animals, especially of atopic dermatitis and/or Flea Allergy Dermatitis, and especially in domestic animals, particularly in dogs.Type: ApplicationFiled: October 15, 2018Publication date: August 20, 2020Applicant: Bayer Animal Health GmbHInventors: Nils GRIEBENOW, Maria De Lourdes MOTTIER, Gerald BEDDIES, Jörg CRAMER, Ulf BÖMER, Iring HEISLER
-
Patent number: 10736896Abstract: The present application relates to novel substituted 5-fluoro-1H-pyrazolopyridines, to processes for their preparation, to their use alone or in combinations for the treatment and/or prophylaxis of diseases, and to their use for producing medicaments for the treatment and/or prophylaxis of diseases, in particular for the treatment and/or prophylaxis of cardiovascular disorders.Type: GrantFiled: May 16, 2018Date of Patent: August 11, 2020Assignee: ADVERIO PHARMA GMBHInventors: Markus Follmann, Johannes-Peter Stasch, Gorden Redlich, Jens Ackerstaff, Nils Griebenow, Walter Kroh, Andreas Knorr, Eva-Maria Becker, Frank Wunder, Volkhart Min-Jian Li, Elke Hartmann, Joachim Mittendorf, Karl-Heinz Schlemmer, Rolf Jautelat, Donald Bierer
-
Publication number: 20200190111Abstract: The present invention covers bicyclic pyrazole compounds of general formula (I): in which G, A, R1, R2, R3, and Q are as defined herein, methods of preparing said compounds, intermediate compounds useful for preparing said compounds, pharmaceutical compositions and combinations comprising said compounds and the use of said compounds for manufacturing pharmaceutical compositions for the treatment, control and/or prevention of diseases, in particular of helminth infections, as a sole agent or in combination with other active ingredients.Type: ApplicationFiled: April 23, 2018Publication date: June 18, 2020Applicant: Bayer Animal Health GMBHInventors: Nils GRIEBENOW, Wei ZHUANG, Daniel KULKE, Adeline KÖHLER, Thomas ILG, Claudia WELZ, Hans-Georg SCHWARZ, Ulrich GÖRGENS, Walter HÜBSCH, Johannes KÖBBERLING
-
Publication number: 20200131175Abstract: The present invention covers azaquinoline compounds of general formula (I), with A being (A1) or (A2), and in which T, R1, R2, R3, R4, R5, R6 and Q are as defined herein, methods of preparing said compounds, intermediate compounds useful for preparing said compounds, pharmaceutical compositions and combinations comprising said compounds and the use of said compounds for manufacturing pharmaceutical compositions for the treatment, control and/or prevention of diseases, in particular of helminth infections, as a sole agent or in combination with other active ingredients.Type: ApplicationFiled: June 22, 2018Publication date: April 30, 2020Applicant: BAYER ANIMAL HEALTH GMBHInventors: Nils GRIEBENOW, Wei ZHUANG, Adeline KÖHLER, Daniel KULKE, Claudia BÖHM, Kirsten BÖRNGEN, Thomas ILG, Hans-Georg SCHWARZ, Werner HALLENBACH, Ulrich GÖRGENS, Walter HÜBSCH, Bernd ALIG, Iring HEISLER, Isa Jana Irina JANSSEN
-
Patent number: 10604525Abstract: The present invention covers Pyrazolopyrimidine compounds of general formula (I), in which n, o, X, Y, R, Q, R1, R2, R3 and R4 are as defined herein, methods of preparing said compounds, intermediate compounds useful for preparing said compounds, pharmaceutical compositions and combinations comprising said compounds and the use of said compounds for manufacturing pharmaceutical compositions for the treatment, control and/or prevention of diseases, in particular of helminth infections, as a sole agent or in combination with other active ingredients.Type: GrantFiled: April 10, 2017Date of Patent: March 31, 2020Assignee: BAYAL ANIMAL HEALTH GMBHInventors: Adeline Köhler, Claudia Welz, Kirsten Börngen, Daniel Kulke, Thomas Ilg, Johannes Köbberling, Walter Hübsch, Hans-Georg Schwarz, Ulrich Görgens, Ulrich Ebbinghaus-Kintscher, Maike Hink, Dirk Nennstiel, Klaus Raming, Martin Adamczewski, Claudia Böhm, Nils Griebenow, Wei Zhuang
-
Publication number: 20200024264Abstract: The present invention covers new quinoline compounds of general formula (I) in which A, R1, R2, R3, R4, R5, R6, and Q are as defined herein, methods of preparing said compounds, intermediate compounds useful for preparing said compounds, pharmaceutical compositions and combinations comprising said compounds and the use of said compounds for manufacturing pharmaceutical compositions for the treatment, control and/or prevention of diseases, in particular of helminth infections, as a sole agent or in combination with other active ingredients.Type: ApplicationFiled: November 6, 2017Publication date: January 23, 2020Applicant: Bayer Animal Health GMBHInventors: Walter HÜBSCH, Johannes KÖBBERLING, Adeline KÖHLER, Hans-Georg SCHWARZ, Daniel KULKE, Claudia WELZ, Thomas ILG, Kirsten BÖRNGEN, Wei ZHUANG, Nils GRIEBENOW, Claudia BÖHM, Niels LINDNER, Maike HINK, Ulrich GÖRGENS
-
Publication number: 20190262463Abstract: The invention relates to site specific homogeneous binder drug conjugates of kinesin spindle protein inhibitors, to active metabolites of these conjugates, to processes for preparing these conjugates, to the use of these conjugates for the treatment and/or prophylaxis of diseases and to the use of these conjugates for preparing medicaments for treatment and/or prevention of diseases, in particular hyperproliferative and/or angiogenic disorders such as, for example, cancer diseases. Such treatments can be carried out as monotherapy or else in combination with other medicaments or further therapeutic measures.Type: ApplicationFiled: June 20, 2016Publication date: August 29, 2019Applicant: BAYER PHARMA AKTIENGESELLSCHAFTInventors: Hans-Georg LERCHEN, Yolanda CANCHO GRANDE, Beatrix STELTE-LUDWIG, Anette SOMMER, Christoph MAHLERT, Anne-Sophie REBSTOCK, Simone GREVEN, Nils GRIEBENOW, Jan TEBBE, Oliver KENSCH
-
Publication number: 20180263981Abstract: The present application relates to novel substituted 5-fluoro-1H-pyrazolopyridines, to processes for their preparation, to their use alone or in combinations for the treatment and/or prophylaxis of diseases, and to their use for producing medicaments for the treatment and/or prophylaxis of diseases, in particular for the treatment and/or prophylaxis of cardiovascular disorders.Type: ApplicationFiled: May 16, 2018Publication date: September 20, 2018Applicant: ADVERIO PHARMA GMBHInventors: Markus FOLLMANN, Johannes-Peter STASCH, Gorden REDLICH, Jens ACKERSTAFF, Nils GRIEBENOW, Walter KROH, Andreas KNORR, Eva-Maria BECKER, Frank WUNDER, Volkhart Min-Jian LI, Elke HARTMANN, Joachim MITTENDORF, Karl-Heinz SCHLEMMER, Rolf JAUTELAT, Donald BIERER
-
Patent number: 10035818Abstract: The invention relates to novel polyethylene glycol (PEG) based prodrug of Adrenomedullin, to processes for preparation thereof, to the use thereof for treatment and/or prevention of diseases, and to the use thereof for producing medicaments for treatment and/or prevention of diseases, especially of cardiovascular, edematous and/or inflammatory disorders.Type: GrantFiled: March 29, 2017Date of Patent: July 31, 2018Assignees: Bayer Pharma Aktiengesellschaft, Bayer Intellectual Property GmbHInventors: Ingo Flamme, Johannes Köbberling, Hans-Georg Lerchen, Nils Griebenow, Rudolf Schohe-Loop, Sven Wittrock, Maria Köllnberger, Frank Wunder, Gorden Redlich, Andreas Knorr, Julie Marley, Iain Pritchard
-
Patent number: 10022453Abstract: The present application relates to novel antibody drug conjugates (ADCs), to active metabolites of these ADCs, to processes for preparing these ADCs, to the use of these ADCs for the treatment and/or prophylaxis of diseases and to the use of these ADCs for preparing medicaments for treatment and/or prevention of diseases, in particular hyperproliferative and/or angiogenic disorders such as, for example, cancer diseases. Such treatments can be carried out as monotherapy or else in combination with other medicaments or further therapeutic measures.Type: GrantFiled: December 10, 2014Date of Patent: July 17, 2018Assignee: BAYER PHARMA AKTIENGESELLSCHAFTInventors: Hans-Georg Lerchen, Sven Wittrock, Nils Griebenow, Beatrix Stelte-Ludwig, Anette Sommer, Sandra Berndt, Christoph Mahlert, Mario Lobell, Carsten Terjung, Simone Greven, Yolanda Cancho Grande
-
Patent number: 9993476Abstract: The present application relates to novel substituted 5-fluoro-1H-pyrazolopyridines, to processes for their preparation, to their use alone or in combinations for the treatment and/or prophylaxis of diseases, and to their use for producing medicaments for the treatment and/or prophylaxis of diseases, in particular for the treatment and/or prophylaxis of cardiovascular disorders.Type: GrantFiled: November 10, 2016Date of Patent: June 12, 2018Assignee: ADVERIO PHARMA GMBHInventors: Markus Follmann, Johannes-Peter Stasch, Gorden Redlich, Jens Ackerstaff, Nils Griebenow, Walter Kroh, Andreas Knorr, Eva-Maria Becker, Frank Wunder, Volkhart Min-Jian Li, Elke Hartmann, Joachim Mittendorf, Karl-Heinz Schlemmer, Rolf Jautelat, Donald Bierer
-
Publication number: 20170313665Abstract: The present invention relates to novel 5-(hydroxyalkyl)-1-phenyl-1,2,4-triazole derivatives, to processes for the preparation of such compounds, to pharmaceutical compositions containing such compounds, and to the use of such compounds or compositions for the treatment and/or prevention of diseases, in particular for the treatment and/or prevention of cardiovascular and renal diseases.Type: ApplicationFiled: October 30, 2015Publication date: November 2, 2017Inventors: Carsten SCHMECK, Michael GERISCH, Nils GRIEBENOW, Peter KOLKHOF, Florian KÖLLING, Anna ENGELEN, Axel KRETSCHMER, Dieter LANG, Klemens LUSTIG, Thomas MONDRITZKI, Elisabeth POOK, Hartmut BECK, Frank SÜßMEIER, Sonja VOLLMER, Pierre WASNAIRE
-
Publication number: 20170273977Abstract: The present application relates to novel substituted 5-fluoro-1H-pyrazolopyridines, to processes for their preparation, to their use alone or in combinations for the treatment and/or prophylaxis of diseases, and to their use for producing medicaments for the treatment and/or prophylaxis of diseases, in particular for the treatment and/or prophylaxis of cardiovascular disorders.Type: ApplicationFiled: November 10, 2016Publication date: September 28, 2017Applicant: ADVERIO PHARMA GMBHInventors: Markus FOLLMANN, Johannes-Peter STASCH, Gorden REDLICH, Jens ACKERSTAFF, Nils GRIEBENOW, Walter KROH, Andreas KNORR, Eva-Maria BECKER, Frank WUNDER, Volkhart Min-Jian LI, Elke HARTMANN, Joachim MITTENDORF, Karl-Heinz SCHLEMMER, Rolf JAUTELAT, Donald BIERER
-
Patent number: 9771352Abstract: The present invention relates to novel 5-(hydroxyalkyl)-1-phenyl-1,2,4-triazole derivatives, to processes for the preparation of such compounds, to pharmaceutical compositions containing such compounds, and to the use of such compounds or compositions for the treatment and/or prevention of diseases, in particular for the treatment and/or prevention of cardiovascular and renal diseases.Type: GrantFiled: November 2, 2015Date of Patent: September 26, 2017Assignee: BAYER PHARMA AKTIENGESELLSCHAFTInventors: Carsten Schmeck, Michael Gerisch, Nils Griebenow, Peter Kolkhof, Florian Kölling, Anna Engelen, Axel Kretschmer, Dieter Lang, Klemens Lustig, Thomas Mondritzki, Elisabeth Pook, Hartmut Beck, Frank Süβmeier, Sonja Vollmer, Pierre Wasnaire
-
Publication number: 20170204137Abstract: The invention relates to novel polyethylene glycol (PEG) based prodrug of Adrenomedullin, to processes for preparation thereof, to the use thereof for treatment and/or prevention of diseases, and to the use thereof for producing medicaments for treatment and/or prevention of diseases, especially of cardiovascular, edematous and/or inflammatory disorders.Type: ApplicationFiled: March 29, 2017Publication date: July 20, 2017Inventors: Ingo FLAMME, Johannes KÖBBERLING, Hans-Georg LERCHEN, Nils GRIEBENOW, Rudolf SCHOHE-LOOP, Sven WITTROCK, Maria KÖLLNBERGER, Frank WUNDER, Gorden REDLICH, Andreas KNORR, Julie MARLEY, Iain PRITCHARD
-
Publication number: 20170145058Abstract: The present application relates to a novel process for the targeted conjugation of peptides and proteins which is characterized by the pairwise C2-bridging of cysteine amino acids via their thiol groups, furthermore to the conjugates of peptides and proteins which can be obtained by such a process and also to the use of such conjugates for the diagnosis and/or treatment of disorders.Type: ApplicationFiled: May 5, 2015Publication date: May 25, 2017Inventors: Nils GRIEBENOW, Stefan BRÄSE, Alicia DILMAC
-
Patent number: 9649363Abstract: The invention relates to novel polyethylene glycol (PEG) based prodrug of Adrenomedullin, to processes for preparation thereof, to the use thereof for treatment and/or prevention of diseases, and to the use thereof for producing medicaments for treatment and/or prevention of diseases, especially of cardiovascular, edematous and/or inflammatory disorders.Type: GrantFiled: December 31, 2015Date of Patent: May 16, 2017Assignees: BAYER INTELLECTUAL PROPERTY GMBH, BAYER PHARMA AKTIENGESELLSCHAFTInventors: Ingo Flamme, Johannes Köbberling, Hans-Georg Lerchen, Nils Griebenow, Rudolf Schohe-Loop, Sven Wittrock, Maria Köllnberger, Frank Wunder, Gorden Redlich, Andreas Knorr, Julie Marley, Iain Pritchard
-
Patent number: 9603936Abstract: The invention relates to novel polyethylene glycol (PEG) based prodrug of Adrenomedullin, to processes for preparation thereof, to the use thereof for treatment and/or prevention of diseases, and to the use thereof for producing medicaments for treatment and/or prevention of diseases, especially of cardiovascular, edematous and/or inflammatory disorders.Type: GrantFiled: October 30, 2012Date of Patent: March 28, 2017Assignee: Bayer Intellectual Property GmbHInventors: Ingo Flamme, Johannes Köbberling, Hans-Georg Lerchen, Nils Griebenow, Rudolf Schohe-Loop, Sven Wittrock, Maria Köllnberger, Frank Wunder, Gorden Redlich, Andreas Knorr, Julie Marley, Iain Pritchard