Abstract: Provided herein are heavy chain constant regions (referred to as “modified heavy chain constant regions”), or functionally equivalent fragments thereof, that enhance biological properties of antibodies relative to the same antibodies in unmodified form. An exemplary modified heavy chain constant region includes an IgG2 hinge and three constant domains (i.e., CH1, CH2, and CH3 domains), wherein one or more of the constant region domains are of a non-IgG2 isotype (e.g., IgG1, IgG3 or IgG4). The heavy chain constant region may comprise wildtype human IgG domain sequences, or variants of these sequences. Also provided herein are methods for enhancing certain biological properties of antibodies that comprise a non-IgG2 hinge, such as internalization, agonism and antagonism, wherein the method comprises replacing the non-IgG2 hinge of the antibody with an IgG2 hinge.

Abstract: In a cyclic anthraquinone process for producing hydrogen peroxide, which comprises a distillation unit with vapor compression for concentrating hydrogen peroxide, aqueous condensate from the distillation unit is passed over a bed of a cation exchange resin in its protonated from to provide a purified condensate, and the purified condensate is used as extractant for extracting hydrogen peroxide in the anthraquinone process, as column reflux for the distillation unit or as a diluent for diluting an aqueous hydrogen peroxide solution.

Abstract: Fabric and home care compositions including a surfactant and a protease.

Abstract: Disclosed herein is one or more subtilisin variant, nucleic acid encoding same, and compositions and methods related to the production and use thereof, including one or more subtilisin variant that has improved stability compared to one or more reference subtilisin.

Abstract: A phosphate-free automatic dishwashing cleaning composition comprising a protease wherein the protease has at least 80%, preferably at least 85%, more preferably at least 90% and especially at least 96% identity with the amino acid sequence of SEQ ID NO:1 or with the amino acid sequence of SEQ ID NO:2 and wherein the protease comprises amino acid substitutions selected from the group consisting of: (i) at least two amino acid substitutions selected from the group consisting of: X198G/A/K/L/Q/R/T/V/S/L, X207Q, X211Q/N and X212Q in combination with at least three amino acid substitutions selected from the group consisting of: X039E, X074D, X099R, X126A, X127E and X128G; or (ii) X039E-X074D-X099R-X116R-X126A-X127E-X128G-X211Q; X039E-X074D-X099R-X126A-X127E-X128G-X211N; X039E-X074D-X099R-X126A-X127E-X128G-X211Q; X039E-X074D-X099R-X126A-X127E-X128G-X207Q; or (iii) any of the proteases of (i) and (ii) further comprising at least one amino acid substitution selected from X242D and X256E; or (iv) X039E-X074D-X099R

Abstract: Disclosed herein is one or more subtilisin variant, nucleic acid encoding same, and compositions and methods related to the production and use thereof, including one or more subtilisin variant that has improved stability and/or soil removal compared to one or more reference subtilisin.

Abstract: In a cyclic anthraquinone process for producing hydrogen peroxide, which comprises a distillation unit with vapor compression for concentrating hydrogen peroxide, aqueous condensate from the distillation unit is passed over a bed of a cation exchange resin in its protonated from to provide a purified condensate, and the purified condensate is used as extractant for extracting hydrogen peroxide in the anthraquinone process, as column reflux for the distillation unit or as a diluent for diluting an aqueous hydrogen peroxide solution.

Abstract: A phosphate-free automatic dishwashing cleaning composition comprising a protease wherein the protease has at least 80%, preferably at least 85%, more preferably at least 90% and especially at least 96% identity with the amino acid sequence of SEQ ID NO:1 or with the amino acid sequence of SEQ ID NO:2 and wherein the protease comprises amino acid substitutions selected from the group consisting of: (i) at least two amino acid substitutions selected from the group consisting of: X198G/A/K/L/Q/R/T/V/S/L, X207Q, X211Q/N and X212Q in combination with at least three amino acid substitutions selected from the group consisting of: X039E, X074D, X099R, X126A, X127E and X128G; or (ii) X039E-X074D-X099R-X116R-X126A-X127E-X128G-X211Q; X039E-X074D-X099R-X126A-X127E-X128G-X211N; X039E-X074D-X099R-X126A-X127E-X128G-X211Q; X039E-X074D-X099R-X126A-X127E-X128G-X207Q; or (iii) any of the proteases of (i) and (ii) further comprising at least one amino acid substitution selected from X242D and X256E; or (iv) X039E-X074D-X099R

Abstract: An apparatus for absorbing electrical noise on cables that includes a housing which contains two partial shells, each partial shell receiving one element which is composed of a material which decreases or absorbs noise. In a closed state, two end sides of the housing each have one opening for a cable to be routed through. The apparatus further includes at least one fixing means for securing the housing to the cable, with the fixing means being arranged on at least one end side of the housing in the region of the opening, and having at least two clips, the limbs of which face one another and can be deformed transverse to the cable and form a slot for receiving the cable in a clamping manner between them. The limbs of the two clips running parallel to one another.

Abstract: An apparatus for absorbing electrical noise on cables that includes a housing which contains two partial shells, each partial shell receiving one element which is composed of a material which decreases or absorbs noise. In a closed state, two end sides of the housing each have one opening for a cable to be routed through. The apparatus further includes at least one fixing means for securing the housing to the cable, with the fixing means being arranged on at least one end side of the housing in the region of the opening, and having at least two clips, the limbs of which face one another and can be deformed transverse to the cable and form a slot for receiving the cable in a clamping manner between them. The limbs of the two clips running parallel to one another.

Abstract: A hybrid gas generator for use in an occupant restraint system for vehicles comprises a pressure chamber (10), a combustion chamber (14) delimited by a combustion chamber wall (16) and containing a pyrotechnic charge (12), and a passage element (20) arranged between the pyrotechnic charge and the pressure chamber. For a form-fitting securing of the passage element (20) on the combustion chamber wall (16), the passage element (20) and the combustion chamber wall (16) have at least in part a conical shape. On the side facing the pyrotechnic charge (12), the passage element (20) has a collar (38) which acts as a spacer between the passage element (20) and the pyrotechnic charge (12).

Abstract: A transport assembly comprises a gas generator having an outer housing which has at least one outflow opening arranged such that a thrust force is exerted onto the outer housing during an outflow of generated gas. The transport assembly further comprises a removable transport cover which is detachably fastened to the outer housing and extends around the outflow opening of the outer housing. Further outflow openings are arranged in the transport cover such that the transport assembly as a whole remains neutral with respect to thrust on activation of the gas generator. A plug connection is provided between the transport cover and the outer housing.

Abstract: A hybrid gas generator for use in an occupant restraint system for vehicles comprises a pressure chamber (10), a combustion chamber (14) delimited by a combustion chamber wall (16) and containing a pyrotechnic charge (12), and a passage element (20) arranged between the pyrotechnic charge and the pressure chamber. For a form-fitting securing of the passage element (20) on the combustion chamber wall (16), the passage element (20) and the combustion chamber wall (16) have at least in part a conical shape. On the side facing the pyrotechnic charge (12), the passage element (20) has a collar (38) which acts as a spacer between the passage element (20) and the pyrotechnic charge (12).

Abstract: A transport assembly comprises a gas generator having an outer housing which has at least one outflow opening arranged such that a thrust force is exerted onto the outer housing during an outflow of generated gas. The transport assembly further comprises a removable transport cover which is detachably fastened to the outer housing and extends around the outflow opening of the outer housing. Further outflow openings are arranged in the transport cover such that the transport assembly as a whole remains neutral with respect to thrust on activation of the gas generator. A plug connection is provided between the transport cover and the outer housing.

Abstract: A hybrid gas generator comprises an elongated cylindrical outer housing, and a pressure chamber that is filled with pressurized gas and that is closed off by a membrane provided on an end face of the pressure chamber. The gas generator further comprises a pyrotechnical propellant charge that is provided for opening the membrane and is accommodated in a preferably bushing-shaped propellant charge housing. The propellant charge housing is connected to the outer housing at a location outside of the pressure chamber and a longitudinal axis of the propellant charge housing extends at a right angle to a longitudinal axis of the outer housing. The generator also has an axial outflow opening situated at one axial end of the outer housing. The outer housing has a circumferential wall with a radial insertion opening for introducing the propellant charge housing.

Abstract: A hybrid gas generator comprises a cylindrical outer housing having a longitudinal axis, and a pressure chamber which is filled with compressed gas and closed by a membrane. A pyrotechnic charge is provided for opening the membrane, the charge being accommodated in a preferably bush-shaped charge housing, which has a longitudinal axis arranged substantially at right-angles to the longitudinal axis of the outer housing and extends into the latter. There is also provided an outflow opening in the outer housing. Inside the outer housing there is a separate holding body provided for retaining the charge housing. The holding body is fastened to the charge housing and, additionally, to a part of the gas generator which is not destructed in an activated state of the gas generator.

Abstract: A hybrid gas generator comprises an elongated cylindrical outer housing, and a pressure chamber that is filled with pressurized gas and that is closed off by a membrane provided on an end face of the pressure chamber. The gas generator further comprises a pyrotechnical propellant charge that is provided for opening the membrane and is accommodated in a preferably bushing-shaped propellant charge housing. The propellant charge housing is connected to the outer housing at a location outside of the pressure chamber and a longitudinal axis of the propellant charge housing extends at a right angle to a longitudinal axis of the outer housing. The generator also has an axial outflow opening situated at one axial end of the outer housing. The outer housing has a circumferential wall with a radial insertion opening for introducing the propellant charge housing.