Patents by Inventor Nils Kuklik

Nils Kuklik has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • TOLL-LIKE RECEPTOR 2 BINDING EPITOPE AND BINDING MEMBER THERETO
    Publication number: 20180141994
    Abstract: The present invention relates to the identification of a TLR2 binding epitope wherein binding of a binding member to the epitope serves to inhibit TLR2 activation and/or signaling. Polypeptide fragments of TLR2 and three-dimensional structures comprising one or more amino acid residues His318, Pro320, Gln321 or Arg321, Tyr323, Lys347, Phe349, Leu371, Glu375, Tyr376 and His398 of TLR2 which define the identified epitope are provided for use in generating binding members. Also provided are binding members which bind to the identified epitope and methods of using same for the treatment and/or prevention of conditions associated with TLR2 activation and/or signaling.
    Type: Application
    Filed: December 14, 2017
    Publication date: May 24, 2018
    Inventors: Nils Kuklik, Wolf-Dieter Schubert
  • Toll-like receptor 2 binding epitope and binding member thereto
    Patent number: 9896497
    Abstract: The present invention relates to the identification of a TLR2 binding epitope wherein binding of a binding member to the epitope serves to inhibit TLR2 activation and/or signalling. Polypeptide fragments of TLR2 and three-dimensional structures comprising one or more amino acid residues His318, Pro320, Gln321 or Arg321, Tyr323, Lys347, Phe349, Leu371, Glu375, Tyr376 and His398 of TLR2 which define the identified epitope are provided for use in generating binding members. Also provided are binding members which bind to the identified epitope and methods of using same for the treatment and/or prevention of conditions associated with TLR2 activation and/or signalling.
    Type: Grant
    Filed: March 29, 2013
    Date of Patent: February 20, 2018
    Assignee: Opsona Therapeutics Limited
    Inventors: Nils Kuklik, Wolf-Dieter Schubert
  • TOLL-LIKE RECEPTOR 2 BINDING EPITOPE AND BINDING MEMBER THERETO
    Publication number: 20150023974
    Abstract: The present invention relates to the identification of a TLR2 binding epitope wherein binding of a binding member to the epitope serves to inhibit TLR2 activation and/or signalling. Polypeptide fragments of TLR2 and three-dimensional structures comprising one or more amino acid residues His318, Pro320, Gln321 or Arg321, Tyr323, Lys347, Phe349, Leu371, Glu375, Tyr376 and His398 of TLR2 which define the identified epitope are provided for use in generating binding members. Also provided are binding members which bind to the identified epitope and methods of using same for the treatment and/or prevention of conditions associated with TLR2 activation and/or signalling.
    Type: Application
    Filed: March 29, 2013
    Publication date: January 22, 2015
    Inventors: Nils Kuklik, Wolf-Dieter Schubert