Patents by Inventor Nils Lonberg

Nils Lonberg has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Human CTLA-4 Antibodies and Their Uses
    Publication number: 20100047244
    Abstract: The present invention provides novel human sequence antibodies against human CTLA-4 and methods of treating human diseases, infections and other conditions using these antibodies.
    Type: Application
    Filed: September 22, 2009
    Publication date: February 25, 2010
    Applicant: Medarex, Inc.
    Inventors: Alan J. Korman, Edward L. Halk, Nils Lonberg, Yashwant M. Deo, Tibor P. Keler
  • Human CTLA-4 antibodies and their uses
    Patent number: 7605238
    Abstract: The present invention provides human sequence antibodies against human CTLA-4 and methods of treating human diseases, infections and other conditions using these antibodies.
    Type: Grant
    Filed: September 7, 2001
    Date of Patent: October 20, 2009
    Assignee: Medarex, Inc.
    Inventors: Alan J. Korman, Edward L. Halk, Nils Lonberg, Yashwant M. Deo, Tibor P. Keler
  • Transgenic Non-Human Animals For Producing Chimeric Antibodies
    Publication number: 20090255002
    Abstract: The invention relates to transgenic non-human animals capable of producing heterologous antibodies and methods for producing human sequence antibodies which bind to human antigens with substantial affinity.
    Type: Application
    Filed: September 26, 2008
    Publication date: October 8, 2009
    Inventors: Nils Lonberg, Robert M. Kay
  • Transgenic transchromosomal rodents for making human antibodies
    Patent number: 7576258
    Abstract: The present invention provides novel transgenic nonhuman mammals capable of producing human sequence antibodies, as well as methods of producing and using these antibodies.
    Type: Grant
    Filed: September 30, 2005
    Date of Patent: August 18, 2009
    Assignees: Medarex, Inc., Kyowa Hakko Kirin Co., Ltd.
    Inventors: Kazuma Tomizuka, Isao Ishida, Nils Lonberg, Edward L. Halk
  • Transgenic non-human animals for producing chimeric antibodies
    Patent number: 7501552
    Abstract: The invention relates to transgenic non-human animals capable of producing heterologous antibodies and methods for producing human sequence antibodies which bind to human antigens with substantial affinity.
    Type: Grant
    Filed: December 10, 2004
    Date of Patent: March 10, 2009
    Assignee: Medarex, Inc.
    Inventors: Nils Lonberg, Robert M. Kay
  • HUMAN ANTIBODIES AS DETECTION REAGENTS
    Publication number: 20080039338
    Abstract: The invention provides in vitro methods of detection using human antibodies. The methods are particularly useful for analyzing human samples containing HAMA or heterophilic antibodies. A human antibody can bind to an analyte in such samples without binding to HAMA or heterophilic antibodies present in the sample. The methods can be effected using a sandwich format among others.
    Type: Application
    Filed: March 12, 2007
    Publication date: February 14, 2008
    Applicants: Biosite, Inc., Medarex, Inc.
    Inventors: Joe Buechler, Gunars Valkirs, Jeff Gray, Nils Lonberg
  • Human antibodies
    Publication number: 20070111259
    Abstract: The invention uses the power of display selection methods to screen libraries of human immunoglobulin genes from nonhuman transgenic animals expressing human immunoglobulins. Such screening produces unlimited numbers of high affinity human antibodies to any target of interest.
    Type: Application
    Filed: September 13, 2006
    Publication date: May 17, 2007
    Applicant: Medarex, Inc.
    Inventors: Joe Buechler, Gunars Valkirs, Jeff Gray, Nils Lonberg
  • Human antibodies as detection reagents
    Patent number: 7189515
    Abstract: The invention provides in vitro methods of detection using human antibodies. The methods are particularly useful for analyzing human samples containing HAMA or heterophilic antibodies. A human antibody can bind to an analyte in such samples without binding to HAMA or heterophilic antibodies present in the samples. The methods can be effected using a sandwich format among others.
    Type: Grant
    Filed: December 6, 2000
    Date of Patent: March 13, 2007
    Assignees: Biosite, Inc., Medarex, Inc.
    Inventors: Joe Buechler, Gunars Valkirs, Jeff Gray, Nils Lonberg
  • Human antibodies
    Patent number: 7135287
    Abstract: The invention uses the power of display selection methods to screen libraries of human immunoglobulin genes from nonhuman transgenic animals expressing human immunoglobulins. Such screening produces unlimited numbers of high affinity human antibodies to any target of interest.
    Type: Grant
    Filed: October 2, 2000
    Date of Patent: November 14, 2006
    Assignees: Biosite, Inc., Medarex, Inc.
    Inventors: Nils Lonberg, Joe Buechler, Jeff Gray, Gunars Valkirs
  • Transgenic non-human animals for producing heterologous antibodies
    Publication number: 20060183195
    Abstract: The invention relates to transgenic non-human animals capable of producing high affinity human sequence antibodies. The invention is also directed to human sequence antibodies specific for human antigens, such as, human CD4. The invention also is directed to methods for producing human sequence antibodies.
    Type: Application
    Filed: February 8, 2006
    Publication date: August 17, 2006
    Inventors: Nils Lonberg, Robert Kay, Dianne Fishwild
  • High affinity human antibodies and human antibodies against human antigens
    Patent number: 7084260
    Abstract: The invention relates to transgenic non-human animals capable of producing high affinity human sequence antibodies. The invention is also directed to human sequence antibodies specific for human antigens, such as, human CD4. The invention also is directed to methods for producing human sequence antibodies.
    Type: Grant
    Filed: October 10, 1996
    Date of Patent: August 1, 2006
    Assignee: GenPharm International, Inc.
    Inventors: Nils Lonberg, Robert M. Kay, Dianne M. Fishwild
  • Transgenic non-human animals capable of producing heterologous antibodies
    Patent number: 7041871
    Abstract: The invention relates to transgenic non-human animals capable of producing heterologous antibodies and methods for producing human sequence antibodies which bind to human antigens with substantial affinity.
    Type: Grant
    Filed: November 28, 2000
    Date of Patent: May 9, 2006
    Assignee: GenPharm International, Inc.
    Inventors: Nils Lonberg, Robert M. Kay
  • Transgenic transchromosomal rodents for making human antibodies
    Patent number: 7041870
    Abstract: The present invention provides novel transgenic nonhuman mammals capable of producing human sequence antibodies, as well as methods of producing and using these antibodies.
    Type: Grant
    Filed: November 30, 2001
    Date of Patent: May 9, 2006
    Assignees: Medarex, Inc., Kirin Brewery Company Limited
    Inventors: Kazuma Tomizuka, Isao Ishida, Nils Lonberg, Edward L. Halk
  • Transgenic transchromosomal rodents for making human antibodies
    Publication number: 20060037093
    Abstract: The present invention provides novel transgenic nonhuman mammals capable of producing human sequence antibodies, as well as methods of producing and using these antibodies.
    Type: Application
    Filed: September 30, 2005
    Publication date: February 16, 2006
    Applicants: Kirin Brewery Company Limited, Medarex, Inc.
    Inventors: Kazuma Tomizuka, Isao Ishida, Nils Lonberg, Edward Halk
  • Transgenic transchromosomal rodents for making human antibodies
    Publication number: 20060026698
    Abstract: The present invention provides novel transgenic nonhuman mammals capable of producing human sequence antibodies, as well as methods of producing and using these antibodies.
    Type: Application
    Filed: September 30, 2005
    Publication date: February 2, 2006
    Applicants: KIRIN BREWERY COMPANY LIMITED, Medarex, Inc.
    Inventors: Kazuma Tomizuka, Isao Ishida, Nils Lonberg, Edward Halk
  • Transgenic non-human animals for producing heterologous and chimeric antibodies
    Publication number: 20060026703
    Abstract: The invention relates to transgenic non-human animals capable of producing heterologous antibodies and methods for producing human sequence antibodies which bind to human antigens with substantial affinity.
    Type: Application
    Filed: December 10, 2004
    Publication date: February 2, 2006
    Applicant: GenPharm International, Inc.
    Inventors: Nils Lonberg, Robert Kay
  • Transgenic non-human animals for producing chimeric antibodies
    Publication number: 20060015957
    Abstract: The invention relates to transgenic non-human animals capable of producing heterologous antibodies and methods for producing human sequence antibodies which bind to human antigens with substantial affinity.
    Type: Application
    Filed: December 10, 2004
    Publication date: January 19, 2006
    Applicant: GenPharm International, Inc.
    Inventors: Nils Lonberg, Robert Kay
  • Transgenic non-human animals for producing heterologous and chimeric antibodies
    Publication number: 20060015949
    Abstract: The invention relates to transgenic non-human animals capable of producing heterologous antibodies and methods for producing human sequence antibodies which bind to human antigens with substantial affinity.
    Type: Application
    Filed: December 10, 2004
    Publication date: January 19, 2006
    Applicant: GenPharm International, Inc.
    Inventors: Nils Lonberg, Robert Kay
  • Human CTLA-4 antibodies
    Patent number: 6984720
    Abstract: The present invention provides human sequence antibodies against CTLA-4 and methods of treating human diseases, infections and other conditions using these antibodies.
    Type: Grant
    Filed: August 24, 2000
    Date of Patent: January 10, 2006
    Assignee: Medarex, Inc.
    Inventors: Alan J. Korman, Edward L. Halk, Nils Lonberg, Yashwant M. Deo, Tibor P. Keler
  • Human CTLA-4 antibodies and their uses
    Publication number: 20050201994
    Abstract: The present invention provides novel human sequence antibodies against human CTLA-4 and methods of treating human diseases, infections and other conditions using these antibodies.
    Type: Application
    Filed: January 20, 2005
    Publication date: September 15, 2005
    Applicant: Medarex, Inc.
    Inventors: Alan Korman, Edward Halk, Nils Lonberg