Patents by Inventor Nils Norrman
Nils Norrman has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Publication number: 20240076650Abstract: The invention relates to processes for purification of poly-tagged products, such as mRNA, from synthetic or biological compositions. The process involves contacting the composition with a oligo d (T)-functionalized chromatography medium comprising a convection-based chromatography material.Type: ApplicationFiled: January 26, 2022Publication date: March 7, 2024Inventors: Peter Lundback, Ronnie Palmgren, Ola Lind, Nils Norrman, Helen Cheek, Susana Brito Dos Santos, Per Denker
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Patent number: 11846635Abstract: The invention discloses an immunoglobulin-binding magnetic bead, comprising a porous matrix and one or more magnetic particles embedded in said matrix, wherein said matrix comprises a porous polymer and at least 10 mg/ml Fc-binding proteinaceous ligands covalently coupled to said porous polymer.Type: GrantFiled: December 21, 2017Date of Patent: December 19, 2023Assignee: CYTIVA SWEDEN ABInventors: Ola Lind, Klaus Gebauer, Eric Faldt, Nils Norrman, Ronnie Palmgren, Jesper Hedberg, Niklas Jungnelius, Karl Liderfelt, Anita Solbrand
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Publication number: 20230333098Abstract: A separation system, and an elution arrangement to be provided in a separation system, for separating a biomolecule from a cell culture are provided.Type: ApplicationFiled: May 15, 2023Publication date: October 19, 2023Inventors: Ola Lind, Johan Fredrik Avallin, Andreas Torbjorn Lundin, Nils Norrman, Ronnie Palmgren, Gustav Jose Rodrigo
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Patent number: 11686726Abstract: A separation system, a method in a separation system and an elution arrangement to be provided in a separation system for separating a biomolecule from a cell culture are provided. The method comprises the steps of: —providing a feed from a cell culture (3; 103; 203) comprising said biomolecule to a magnetic separator (5; 105; 205) and providing to the magnetic separator magnetic beads comprising ligands capable of binding this biomolecule; —separating by the magnetic separator said magnetic beads with bound biomolecules from the rest of the feed; —forwarding said magnetic beads as a slurry with an added buffer to an elution cell (7; 107; 207); —eluting the bound biomolecules in the elution cell.Type: GrantFiled: December 27, 2017Date of Patent: June 27, 2023Assignee: Cytiva Sweden ABInventors: Ola Lind, Johan Fredrik Avallin, Andreas Torbjorn Lundin, Nils Norrman, Ronnie Palmgren, Gustav Jose Rodrigo
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Patent number: 11439926Abstract: The present invention is within the field of chromatography. More precisely, it relates to a novel chromatography medium, namely a hydrophobic medium provided with different lids excluding molecules over a certain size due to the porosity of the hydrophobic medium and/or the porosity of the lid. The invention also relates to use of the separation medium for purification of large molecules, which do not enter the separation medium, as well as small molecules, which enter the separation medium and are eluted from there.Type: GrantFiled: December 3, 2019Date of Patent: September 13, 2022Assignee: Cytiva BioProcess R&D ABInventors: Jan Bergstrom, Gunnar Glad, Bo-Lennart Johansson, Jean-Luc Maloisel, Nils Norrman, Tobias E. Soderman
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Publication number: 20220266170Abstract: The present invention is within the field of chromatography. More precisely, it relates to a novel chromatography medium, namely a hydrophobic medium provided with different lids excluding molecules over a certain size due to the porosity of the hydrophobic medium and/or the porosity of the lid. The invention also relates to use of the separation medium for purification of large molecules, which do not enter the separation medium, as well as small molecules, which enter the separation medium and are eluted from there.Type: ApplicationFiled: May 10, 2022Publication date: August 25, 2022Inventors: Jan Bergstrom, Gunnar Glad, Bo-Lennart Johansson, Jean-Luc Maloisel, Nils Norrman, Tobias E. Soderman
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Publication number: 20220229052Abstract: The present disclosure is directed to a method for separating a biomolecule from a cell culture or from a biological solution, comprising the steps of: (a) providing magnetic particles comprising ligands capable of binding the biomolecule; (b) contacting a cell culture or a biological solution comprising the biomolecule with the magnetic particles to obtain magnetic particles comprising the bound biomolecule; (c) retaining the magnetic particles with a magnetic field in a magnetic separator; (d) optionally washing the magnetic particles with a washing liquid; (e1) providing a flow of an elution liquid through the magnetic separator to elute the bound biomolecule from the magnetic particles while retaining the magnetic particles with the magnetic field in the magnetic separator; (f1) forwarding the biomolecule eluted from the magnetic separator to a membrane chromatography device; (g1) separating the biomolecule from impurities and/or contaminants by membrane chromatography.Type: ApplicationFiled: March 23, 2020Publication date: July 21, 2022Inventors: Ola Lind, Nils Norrman, Sara Häggblad Sahlberg, Ronnie Palmgren
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Patent number: 11014069Abstract: The present invention relates to a method to improve chromatography beads. More closely, the invention relates to a novel method for production of dextran-containing porous media and chromatography media produced with this method. In the method, the chromatography media is subjected to dextranase-treatment leading to improved pressure-flow properties of the media.Type: GrantFiled: October 28, 2016Date of Patent: May 25, 2021Assignee: Cytiva BioProcess R&D ABInventors: Nils Norrman, Mattias Algotsson, Stefan D. Eriksson
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Publication number: 20200101398Abstract: The present invention is within the field of chromatography. More precisely, it relates to a novel chromatography medium, namely a hydrophobic medium provided with different lids excluding molecules over a certain size due to the porosity of the hydrophobic medium and/or the porosity of the lid. The invention also relates to use of the separation medium for purification of large molecules, which do not enter the separation medium, as well as small molecules, which enter the separation medium and are eluted from there.Type: ApplicationFiled: December 3, 2019Publication date: April 2, 2020Applicant: GE Healthcare BioProcess R&D ABInventors: JAN BERGSTROM, GUNNAR GLAD, BO-LENNART JOHANSSON, JEAN-LUC MALOISEL, NILS NORRMAN, TOBIAS E. SODERMAN
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Publication number: 20200087614Abstract: A separation system, a method in a separation system and an elution arrangement to be provided in a separation system for separating a biomolecule from a cell culture are provided. The method comprises the steps of: —providing a feed from a cell culture (3; 103; 203) comprising said biomolecule to a magnetic separator (5; 105; 205) and providing to the magnetic separator magnetic beads comprising ligands capable of binding this biomolecule; —separating by the magnetic separator said magnetic beads with bound biomolecules from the rest of the feed; —forwarding said magnetic beads as a slurry with an added buffer to an elution cell (7; 107; 207); —eluting the bound biomolecules in the elution cell.Type: ApplicationFiled: December 27, 2017Publication date: March 19, 2020Inventors: Ola Lind, Johan Fredrik Avallin, Andreas Torbjorn Lundin, Nils Norrman, Ronnie Palmgren, Gustav Jose Rodrigo
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Patent number: 10562007Abstract: The present invention relates to a separation matrix, which comprises a support; extenders coupled to an outer part of said support; and ligands coupled to said extenders, wherein the part of the support to which the extenders are coupled constitutes less than 50% of the volume of the separation matrix. The invention also embraces a method of preparing such a separation matrix, as well as a process wherein the separation media is used.Type: GrantFiled: July 22, 2008Date of Patent: February 18, 2020Assignee: GE Healthcare BioProcess R&D ABInventors: Andreas Axen, Jan Bergstrom, Gunnar Glad, Bo-Lennart Johansson, Nils Norrman
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Patent number: 10493380Abstract: The present invention is within the field of chromatography. More precisely, it relates to a novel chromatography medium, namely a hydrophobic medium provided with different lids excluding molecules over a certain size due to the porosity of the hydrophobic medium and/or the porosity of the lid. The invention also relates to use of the separation medium for purification of large molecules, which do not enter the separation medium, as well as small molecules, which enter the separation medium and are eluted from there.Type: GrantFiled: June 15, 2016Date of Patent: December 3, 2019Assignee: GE Healthcare BioProcess R&D ABInventors: Jan Bergstrom, Gunnar Glad, Bo-Lennart Johansson, Jean-Luc Maloisel, Nils Norrman, Tobias E. Soderman
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Publication number: 20190339261Abstract: The invention discloses an immunoglobulin-binding magnetic bead, comprising a porous matrix and one or more magnetic particles embedded in said matrix, wherein said matrix comprises a porous polymer and at least 10 mg/ml Fc-binding proteinaceous ligands covalently coupled to said porous polymer.Type: ApplicationFiled: December 21, 2017Publication date: November 7, 2019Inventors: Ola Lind, Klaus Gebauer, Eric Faldt, Nils Norrman, Ronnie Palmgren, Jesper Hedberg, Niklas Jungnelius, Karl Liderfelt, Anita Solbrand
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Patent number: 10429359Abstract: Automated two step chromatography purification system comprising a, system controller, a capture flow path comprising at least one pump, an elution flow path comprising at least one pump, and a valve arrangement for selective connection of two capture columns to the capture flow path and the elution flow path respectively such that both flow paths may be operated simultaneously and in parallel.Type: GrantFiled: February 13, 2015Date of Patent: October 1, 2019Assignee: GE HEALTHCARE BIO-SCIENCES ABInventors: Christer Olof Eriksson, Nils Norrman
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Patent number: 10421074Abstract: The present invention provides a microplate comprised of multiwell strips connected in such a way as to permit the microplate to unfold and to pass in a linear fashion past a fraction collector and then re-fold back into a microplate configuration. Furthermore, the invention provides for the use of the microplates of the invention in a variety of different laboratory methods.Type: GrantFiled: November 25, 2014Date of Patent: September 24, 2019Assignee: GE Healthcare Bio-Sciences ABInventors: Nils Norrman, Henrik Ostlin
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Publication number: 20180304231Abstract: The present invention relates to a method to improve chromatography beads. More closely, the invention relates to a novel method for production of dextran-containing porous media and chromatography media produced with this method. In the method, the chromatography media is subjected to dextranase-treatment leading to improved pressure-flow properties of the media.Type: ApplicationFiled: October 28, 2016Publication date: October 25, 2018Applicant: GE Healthcare Bio-Sciences ABInventors: Nils Norrman, Mattias Algotsson, Stefan D. Eriksson
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Patent number: 10040073Abstract: A method for purifying a substance in a solution in a simple streamlined process using a magnetic porous particle. For easy small scale purification of a substance, the magnetic porous particle is coated with either a hydrophilic or hydrophobic liquid and transferred into a second liquid containing the substance under conditions which allow said substance to partition into the first liquid within said magnetic porous particle. Finally the magnetic porous particle is removed from said second liquid, wherein the first and second liquid are substantially immiscible and the partition coefficient P of the substance between the first and second liquid is greater than 1.Type: GrantFiled: January 29, 2014Date of Patent: August 7, 2018Assignee: GE Healthcare Bio-Sciences ABInventors: Nils Norrman, Pierre Le Greves
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Patent number: 9987628Abstract: The present invention provides methods and systems for eluting and an analyte from a solid phase. The invention further provides methods and systems for transferring liquid analyte reagent mixtures from a solid phase to a second vessel, such as a microtiter plate well. The invention is useful in the manipulation of biological molecules such as nucleic acids, carbohydrates, proteins and peptides. In particular, the invention has utility for manipulating proteins and peptides in isoelectric focusing gels.Type: GrantFiled: November 26, 2014Date of Patent: June 5, 2018Assignee: GE HEALTHCARE BIO-SCIENCES ABInventors: Tobias Ingemar Solderman, Nils Norrman, Henrik Ostlin, Susanna Lindman, David Carl Martin Bergman, Peter Mats Oliviusson
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Publication number: 20170153210Abstract: Automated two step chromatography purification system comprising a, system controller, a capture flow path comprising at least one pump, an elution flow path comprising at least one pump, and a valve arrangement for selective connection of two capture columns to the capture flow path and the elution flow path respectively such that both flow paths may be operated simultaneously and in parallel.Type: ApplicationFiled: February 13, 2015Publication date: June 1, 2017Inventors: Christer Olof ERIKSSON, Nils NORRMAN
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Publication number: 20170050121Abstract: The present invention is within the field of chromatography. More precisely, it relates to a novel chromatography medium, namely a hydrophobic medium provided with different lids excluding molecules over a certain size due to the porosity of the hydrophobic medium and/or the porosity of the lid. The invention also relates to use of the separation medium for purification of large molecules, which do not enter the separation medium, as well as small molecules, which enter the separation medium and are eluted from there.Type: ApplicationFiled: June 15, 2016Publication date: February 23, 2017Inventors: JAN BERGSTROM, GUNNAR GLAD, BO-LENNART JOHANSSON, JEAN-LUC MALOISEL, NILS NORRMAN, TOBIAS E. SODERMAN