Patents by Inventor Nils Thoennissen

Nils Thoennissen has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • BOOSTING IMMUNE DEFENSE BY UPREGULATING CCAAT/ENHANCER BINDING PROTEIN EPSILON
    Publication number: 20130052162
    Abstract: The present invention demonstrates the important role of C/EBP? in innate immune response against pathogens. Specifically, the inventors showed that in the absence of functional C/EBP?, mice are severely impaired in their ability to clear S. aureus infection. Neutrophils are particularly affected, and susceptibility to S. aureus can be rectified by treatment with interferon-gamma (IFN-?). Importantly, increased activity of C/EBP?, either by induced overexpression of C/EBPE or by application of nicotinamide or an analog, derivative or salt thereof, dramatically enhances immune killing of S. aureus and leads to amelioration of infection.
    Type: Application
    Filed: April 20, 2011
    Publication date: February 28, 2013
    Applicant: CEDARS-SINAI MEDICAL CENTER
    Inventors: H. Phillip Koeffler, George Y. Liu, Nils Thoennissen, Pierre Kyme, Adrian F. Gombart