Abstract: The invention relates in a first aspect to an azadibenzocyclooctyne derivative according to formula (I) or a salt thereof having specific substituents at the benzo rings of the DIBAC structure and having specific substituents connected to the nitrogen atom of the DIBAC structure. A second aspect of the invention is directed to a conjugate of formula (II), wherein a substituent R6 is connected to the N atom of the 8 membered ring of the DIBAC structure via a linker structure —C(?O)-[L]n-Z—. A third aspect of the invention relates to a method for the modification of a target molecule, wherein a conjugate according to the second aspect is reacted with a target molecule comprising a 1,3-dipole group or a 1,3-(hetero)diene group. In a fourth aspect, the invention is directed to the use of the conjugate according to the second aspect for bioorthogonal labeling and/or modification of a target molecule.

Abstract: The present invention relates to a cooled turbine blade for a gas-turbine engine having at least one cooling duct (14) extending radially, relative to a rotary axis of the gas-turbine engine, inside the airfoil and air-supply ducts (12) issuing into said cooling duct, characterized in that the cooling duct (14) extends into the blade root (6) in order to generate close to the wall a cooling airflow moved at high circumferential velocity and radially in helical form and that in the area of the blade root (6) at least one nozzle-shaped air-supply duct (12) issues into the cooling duct (14) tangentially or with a tangential velocity component.

Abstract: The present invention relates to a cooled turbine blade for a gas-turbine engine having at least one cooling duct (14) extending radially, relative to a rotary axis of the gas-turbine engine, inside the airfoil and air-supply ducts (12) issuing into said cooling duct, characterized in that the cooling duct (14) extends into the blade root (6) in order to generate close to the wall a cooling airflow moved at high circumferential velocity and radially in helical form and that in the area of the blade root (6) at least one nozzle-shaped air-supply duct (12) issues into the cooling duct (14) tangentially or with a tangential velocity component.