Abstract: Multiparametric analysis is performed at the single cell level of biological samples obtained from an individual during pregnancy to obtain a determination of changes in the interactome, integrating metabolome, immunome and proteome features during pregnancy that are predictive of time to onset of labor.

Abstract: Methods to compute gestational age and applications thereof are described. Generally, systems utilize analyte measurements derived from a urine sample to determine a gestational age, which can be used as a basis to perform interventions and treat individuals.

Abstract: A method can include, monitoring a blood glucose level of a subject. When the blood glucose level deviates from a target response, a food consumed by the subject corresponding to the blood glucose level can be determined and one or more alternative actions can be displayed for the user. The alternative actions can be selected generate a blood glucose response that deviates from the target response less than the food consumed without any alternative action. The blood glucose level and alternative action can be displayed on an electronic device. Corresponding systems and devices are also disclosed.

Abstract: Multiparametric analysis is performed at the single cell level of biological samples obtained from an individual during pregnancy to obtain a determination of changes in immune cell subsets, which changes include, without limitation, altered activation states of proteins involved in signaling pathways. Changes occur in signaling pathways of these immune cells that are predictive of propensity to develop preeclampsia in the pregnancy.