Patents by Inventor Nimanthi Jayathilaka

Nimanthi Jayathilaka has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Small molecules modulator of epigenetic regulation and their therapeutic applications
    Patent number: 9750731
    Abstract: Disclosed are methods and compositions for modulating the function of transcription factors, especially transcription factors that recruit epigenetic regulators (histone modifying enzymes) to specific DNA promoters. The targeted transcription factors include but are not limited to the myocyte enhancing factor (MEF2), the forkhead/winged helix transcription factor FOXP3 and the transcription factor GATA3. Also disclosed are small molecule modulators of MEF2 and its associated factors that include but not limited to histone deacetylases (HDACs), p300/CBP and Cabin1 and the therapeutic applications thereof.
    Type: Grant
    Filed: August 21, 2014
    Date of Patent: September 5, 2017
    Assignee: UNIVERSITY OF SOUTHERN CALIFORNIA
    Inventors: Lin Chen, Nimanthi Jayathilaka, Aidong Han, Nicos Petasis
  • Small Molecules Modulator of Epigenetic Regulation and Their Therapeutic Applications
    Publication number: 20150150860
    Abstract: Disclosed are methods and compositions for modulating the function of transcription factors, especially transcription factors that recruit epigenetic regulators (histone modifying enzymes) to specific DNA promoters. The targeted transcription factors include but are not limited to the myocyte enhancing factor (MEF2), the forkhead/winged helix transcription factor FOXP3 and the transcription factor GATA3.
    Type: Application
    Filed: August 21, 2014
    Publication date: June 4, 2015
    Applicant: UNIVERSITY OF SOUTHERN CALIFORNIA
    Inventors: Lin CHEN, Nimanthi JAYATHILAKA, Aidong HAN, Nicos PETASIS
  • SMALL MOLECULE MODULATORS OF EPIGENETIC REGULATION AND THEIR THERAPEUTIC APPLICATIONS
    Publication number: 20140343101
    Abstract: Disclosed are methods and compositions for modulating the function of transcription factors, especially transcription factors that recruit epigenetic regulators (histone modifying enzymes) to specific DNA promoters. The targeted transcription factors include but are not limited to the myocyte enhancing factor (MEF2), the forkhead/winged helix transcription factor FOXP3 and the transcription factor GATA3.
    Type: Application
    Filed: February 26, 2014
    Publication date: November 20, 2014
    Applicant: UNIVERSITY OF SOUTHERN CALIFORNIA
    Inventors: Lin Chen, Nimanthi Jayathilaka, Aidong Han, Nicos A. Petasis
  • Small molecules modulator of epigenetic regulation and their therapeutic applications
    Patent number: 8846932
    Abstract: Disclosed are methods and compositions for modulating the function of transcription factors, especially transcription factors that recruit epigenetic regulators (histone modifying enzymes) to specific DNA promoters. The targeted transcription factors include but are not limited to the myocyte enhancing factor (MEF2), the forkhead/winged helix transcription factor FOXP3 and the transcription factor GATA3. Also disclosed are small molecule modulators of MEF2 and its associated factors that include but not limited to histone deacetylases (HDACs), p300/CBP and Cabin1 and the therapeutic applications thereof.
    Type: Grant
    Filed: March 13, 2013
    Date of Patent: September 30, 2014
    Assignee: University of Southern California
    Inventors: Lin Chen, Nimanthi Jayathilaka, Aidong Han, Nicos A. Petasis
  • Small molecules modulator of epigenetic regulation and their therapeutic applications
    Patent number: 8697729
    Abstract: Disclosed are methods and compositions for modulating the function of transcription factors, especially transcription factors that recruit epigenetic regulators (histone modifying enzymes) to specific DNA promoters. The targeted transcription factors include but are not limited to the myocyte enhancing factor (MEF2), the forkhead/winged helix transcription factor FOXP3 and the transcription factor GATA3. Also disclosed are small molecule modulators of MEF2 and its associated factors that include but not limited to histone deacetylases (HDACs), p300/CBP and Cabin1 and the therapeutic applications thereof.
    Type: Grant
    Filed: November 5, 2009
    Date of Patent: April 15, 2014
    Assignee: University of Southern California
    Inventors: Lin Chen, Nimanthi Jayathilaka, Aidong Han, Nicos Petasis
  • Small Molecules Modulator of Epigenetic Regulation and Their Therapeutic Applications
    Publication number: 20130281703
    Abstract: Disclosed are methods and compositions for modulating the function of transcription factors, especially transcription factors that recruit epigenetic regulators (histone modifying enzymes) to specific DNA promoters. The targeted transcription factors include but are not limited to the myocyte enhancing factor (MEF2), the forkhead/winged helix transcription factor FOXP3 and the transcription factor GATA3. Also disclosed are small molecule modulators of MEF2 and its associated factors that include but not limited to histone deacetylases (HDACs), p300/CBP and Cabin1 and the therapeutic applications thereof.
    Type: Application
    Filed: March 13, 2013
    Publication date: October 24, 2013
    Inventors: Lin CHEN, Nimanthi JAYATHILAKA, Aidong HAN, Nicos A. PETASIS
  • Small Molecules Modulator of Epigenetic Regulation and Their Therapeutic Applications
    Publication number: 20110275674
    Abstract: Disclosed are methods and compositions for modulating the function of transcription factors, especially transcription factors that recruit epigenetic regulators (histone modifying enzymes) to specific DNA promoters. The targeted transcription factors include but are not limited to the myocyte enhancing factor (MEF2), the forkhead/winged helix transcription factor FOXP3 and the transcription factor GATA3. Also disclosed are small molecule modulators of MEF2 and its associated factors that include but not limited to histone deacetylases (HDACs), p300/CBP and Cabin1 and the therapeutic applications thereof.
    Type: Application
    Filed: November 5, 2009
    Publication date: November 10, 2011
    Applicant: UNIVERSITY OF SOUTHERN CALIFORNIA
    Inventors: Lin Chen, Nimanthi Jayathilaka, Aidong Han, Nicos A. Petasis