Abstract: A computer implemented method and associated hardware provides optimization of a delivery or settlement process for a group of portfolios. Data records, identified in a portfolio data structure, are indicative of obligations between participants. A graph data structure is generated and includes vertex data records representing the participants and edge data records representing the obligations between participants. The graph structure is analyzed for at least one circular path. A first edge washing out at least a portion of the circular path is identified. An update message is generated in response to the first edge.

Abstract: A computer implemented method and associated hardware provides optimization of a delivery or settlement process for a group of portfolios and calculation of a transaction suggestion to one or more participants. Data records, identified in a portfolio data structure, are indicative of obligations between participants. A weighted directed graph data structure is generated and includes vertex data records representing the participants and edge data records representing the obligations between participants. The weighted directed graph structure is analyzed for at least one series of multiple vertex data records or multiple edge data records. A proposed edge associated with a first vertex of the series and a second vertex of the at least one series is identified. A report is generated that describes at least one transaction in response to the proposed edge associated with the first vertex of the series and the second vertex of the series for the at least one of the participants.

Abstract: A computer implemented method for optimizing a delivery or settlement process for a plurality of portfolios of a plurality of participants. Data records indicative of obligations between the plurality of participants are identified. A weighted directed graph data structure is generated that comprises vertex data records representing the plurality of participants and edge data records representing the obligations between the participants. All paths of edge data records where a vertex data record is reachable from itself in the weighted directed graph data structure are identified. The data records indicative of obligations between the plurality of participants are altered based on the identified paths.

Abstract: A computer implemented method for optimizing a delivery or settlement process for a plurality of portfolios of a plurality of participants. Data records indicative of obligations between the plurality of participants are identified. A weighted directed graph data structure is generated that comprises vertex data records representing the plurality of participants and edge data records representing the obligations between the participants. All paths of edge data records where a vertex data record is reachable from itself in the weighted directed graph data structure are identified. The data records indicative of obligations between the plurality of participants are altered based on the identified paths.

Abstract: A computer implemented method and associated hardware provides optimization of a delivery or settlement process for a group of portfolios and calculation of a transaction suggestion to one or more participants. Data records, identified in a portfolio data structure, are indicative of obligations between participants. A weighted directed graph data structure is generated and includes vertex data records representing the participants and edge data records representing the obligations between participants. The weighted directed graph structure is analyzed for at least one series of multiple vertex data records or multiple edge data records. A proposed edge associated with a first vertex of the series and a second vertex of the at least one series is identified. A report is generated that describes at least one transaction in response to the proposed edge associated with the first vertex of the series and the second vertex of the series for the at least one of the participants.

Abstract: A computer implemented method for optimizing a delivery or settlement process for a plurality of portfolios of a plurality of participants. Data records indicative of obligations between the plurality of participants are identified. A weighted directed graph data structure is generated that comprises vertex data records representing the plurality of participants and edge data records representing the obligations between the participants. All paths of edge data records where a vertex data record is reachable from itself in the weighted directed graph data structure are identified. The data records indicative of obligations between the plurality of participants are altered based on the identified paths.

Abstract: The invention provides optical instrument systems and methods for analyzing signals from biological arrays, and performing analytical amplification reactions for identifying the presence or absence of a target nucleic acid sequence in a sample to be analyzed.

Abstract: Microfluidic devices and methods for flow cytometry are described. In described examples, various sample handling and preparation steps may be carried out within a same microfluidic device as flow cytometry steps. A combination of imaging and flow cytometry is described. In some examples, spiral microchannels serve as incubation chambers. Examples of automated sample handling and flow cytometry are described.

Abstract: A microfabricated, a nanoliter capillary viscometer includes a first channel that is defined by a first channel-defining surface in a first substrate and a second channel defining surface in a second substrate. The progress of liquid through this first channel is monitored and used to determine viscosity. Viscosities in the range of 1 cP to 1000 cP are easily measured. Self-calibrating versions of the viscometer are also disclosed.

Abstract: A microfabricated, a nanoliter capillary viscometer includes a first channel that is defined by a first channel-defining surface in a first substrate and a second channel defining surface in a second substrate. The progress of liquid through this first channel is monitored and used to determine viscosity. Viscosities in the range of 1 cP to 1000 cP are easily measured. Self-calibrating versions of the viscometer are also disclosed.