Patents by Inventor Nina Bacher Reuven

Nina Bacher Reuven has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Viral recombinases, related articles, and methods of use thereof
    Patent number: 7135324
    Abstract: A Herpes simplex virus (HSV) recombinase comprises a purified or isolated alkaline nuclease and a single stranded DNA binding protein. In HSV-1, the alkaline nuclease is the UL12 protein and the single stranded DNA binding protein is the ICP8 protein. The HSV recombinase can be purified from an in vitro expression system or can be expressed in an appropriate vector or vectors wherein the DNAs encoding the polypeptides are operatively linked to expression control sequences. Methods of use of the HSV recombinase include cloning, treating cells and organisms, and producing transgenic animals. The HSV recombinase can be in the form of a kit useful for cloning.
    Type: Grant
    Filed: September 4, 2003
    Date of Patent: November 14, 2006
    Assignee: The University of Connecticut
    Inventors: Sandra Weller, Richard S. Myers, Nina Bacher Reuven
  • Viral recombinases, related articles, and methods of use thereof
    Publication number: 20040141994
    Abstract: A Herpes simplex virus (HSV) recombinase comprises a purified or isolated alkaline nuclease and a single stranded DNA binding protein. In HSV-1, the alkaline nuclease is the UL12 protein and the single stranded DNA binding protein is the ICP8 protein. The HSV recombinase can be purified from an in vitro expression system or can be expressed in an appropriate vector or vectors wherein the DNAs encoding the polypeptides are operatively linked to expression control sequences. Methods of use of the HSV recombinase include cloning, treating cells and organisms, and producing transgenic animals. The HSV recombinase can be in the form of a kit useful for cloning.
    Type: Application
    Filed: September 4, 2003
    Publication date: July 22, 2004
    Inventors: Sandra Weller, Richard S. Myers, Nina Bacher Reuven
  • Methods of replicating a DNA molecule for repair of DNA lesion damage or for mutagenesis
    Patent number: 6333178
    Abstract: UmuC is found to be a translesion replication DNA polymerase which replicates in the presence of UmuD′, RecA and SSB through a DNA lesion of damaged DNA molecule and which is found to be highly mutagenic during in vitro gap-filling replication. A method for replicating a DNA molecule with DNA lesion damage and a method for mutagenesis of a DNA molecule are provided.
    Type: Grant
    Filed: September 12, 2000
    Date of Patent: December 25, 2001
    Assignee: Yeda Research and Development Co. Ltd.
    Inventors: Zvi Livneh, Nina Bacher Reuven, Guy Tomer