Abstract: Disclosed herein are systems, compositions, and methods for modifying the human dystrophin gene (DMD). Systems, compositions, and methods may comprise a compact Type V CRISPR-associated (Cas) protein, an RNA-dependent DNA polymerase, and/or one or more guide nucleic acids or uses thereof. These systems, compositions, and methods may be useful for treating diseases such as Duchenne muscular dystrophy (DMD).

Abstract: Provided herein are compositions, systems, and methods comprising effector proteins for treating DUX4 mutations. These effector proteins may be characterized as CRISPR-associated (Cas) proteins. Various compositions, systems, and methods of the present disclosure may leverage the activities of these effector proteins for the modification, detection, and engineering the DUX4 gene.

Abstract: Certificates issued by a CA are distributed across multiple CRLs. Each certificate issued by the CA is assigned to a specific CRL, and the address of that CRL is written to the appropriate field of the certificate, such that an authenticating application can subsequently determine if the certificate is revoked. When the CA revokes a specific one of the issued certificates, it determines to which CRL the revoked certificate is assigned, and updates the specific CRL accordingly. In some embodiments, a single one of the multiple CRLs is active for assignment of certificates at any given time, and each certificate issued by the CA is assigned to the currently active CRL. In other embodiments, assignments of issued certificates are distributed between different ones of a pre-determined number of multiple CRLs by applying a statistical distribution formula to each issued certificate to determine a corresponding target CRL.

Abstract: Provided are insulative apparatus and methods of forming insulative apparatus. As an example, a method of forming an insulative apparatus can include connecting a barrier material to a mold; injecting a polyurethane foam composition into the mold, wherein the polyurethane foam composition includes a polyol, an isocyanate, and supercritical carbon dioxide; curing the polyurethane foam composition to form a polyurethane foam and applying a vacuum to the mold to provide a pressure from 1 millibar to 500 millibar.

Abstract: Certificates issued by a CA are distributed across multiple CRLs. Each certificate issued by the CA is assigned to a specific CRL, and the address of that CRL is written to the appropriate field of the certificate, such that an authenticating application can subsequently determine if the certificate is revoked. When the CA revokes a specific one of the issued certificates, it determines to which CRL the revoked certificate is assigned, and updates the specific CRL accordingly. In some embodiments, a single one of the multiple CRLs is active for assignment of certificates at any given time, and each certificate issued by the CA is assigned to the currently active CRL. In other embodiments, assignments of issued certificates are distributed between different ones of a pre-determined number of multiple CRLs by applying a statistical distribution formula to each issued certificate to determine a corresponding target CRL.

Abstract: Certificates issued by a CA are distributed across multiple CRLs. Each certificate issued by the CA is assigned to a specific CRL, and the address of that CRL is written to the appropriate field of the certificate, such that an authenticating application can subsequently determine if the certificate is revoked. When the CA revokes a specific one of the issued certificates, it determines to which CRL the revoked certificate is assigned, and updates the specific CRL accordingly. In some embodiments, a single one of the multiple CRLs is active for assignment of certificates at any given time, and each certificate issued by the CA is assigned to the currently active CRL. In other embodiments, assignments of issued certificates are distributed between different ones of a pre-determined number of multiple CRLs by applying a statistical distribution formula to each issued certificate to determine a corresponding target CRL.

Abstract: The disclosed computer-implemented method for evaluating wireless network connection security may include (i) detecting a wireless network connection from an Internet-of-Things device through sniffing, (ii) automatically selecting the wireless network connection as the wireless network connection to be evaluated in an analysis of network connection security, (iii) performing, in response to the automatic selecting of the wireless network connection as the wireless network connection to be evaluated, the analysis of network connection security to determine whether the wireless network connection is secure, and (iv) automatically reporting, through a physical output of the computing device and in response to performing the analysis of network connection security, a result of the analysis of network connection security to inform a user about the safety of the Internet-of-Things device. Various other methods, systems, and computer-readable media are also disclosed.

Abstract: Provided are insulative apparatus and methods of forming insulative apparatus. As an example, a method of forming an insulative apparatus can include connecting a barrier material to a mold; injecting a polyurethane foam composition into the mold, wherein the polyurethane foam composition includes a polyol, an isocyanate, and supercritical carbon dioxide; curing the polyurethane foam composition to form a polyurethane foam and applying a vacuum to the mold to provide a pressure from 1 millibar to 500 millibar.

Abstract: The present invention provides anti-hemagglutinin antibodies, compositions comprising anti-hemagglutinin antibodies, and methods of using the same.

Abstract: Techniques are disclosed for accelerating online certificate status protocol (OCSP) response distribution to relying parties using a content delivery network (CDN). A certificate authority generates updated OCSP responses for OCSP responses cached in the CDN that are about to expire. In addition, the certificate authority pre-generates cache keys in place of CDNs generating the keys. The certificate authority sends the OCSP responses and the cache keys in one transaction, and the CDN, in turn, serves requests for the OCSP responses using the cache keys. For new certificates, a private CDN is pre-populated with an OCSP response for a certificate concurrent with that certificate being issued. Doing so effectively uses the PCDN as an origin server for OCSP responses, reducing CA infrastructure needs.

Abstract: Certificates issued by a CA are distributed across multiple CRLs. Each certificate issued by the CA is assigned to a specific CRL, and the address of that CRL is written to the appropriate field of the certificate, such that an authenticating application can subsequently determine if the certificate is revoked. When the CA revokes a specific one of the issued certificates, it determines to which CRL the revoked certificate is assigned, and updates the specific CRL accordingly. In some embodiments, a single one of the multiple CRLs is active for assignment of certificates at any given time, and each certificate issued by the CA is assigned to the currently active CRL. In other embodiments, assignments of issued certificates are distributed between different ones of a pre-determined number of multiple CRLs by applying a statistical distribution formula to each issued certificate to determine a corresponding target CRL.

Abstract: The present invention provides anti-hemagglutinin antibodies, compositions comprising anti-hemagglutinin antibodies, and methods of using the same.

Abstract: Certificates issued by a CA are distributed across multiple CRLs. Each certificate issued by the CA is assigned to a specific CRL, and the address of that CRL is written to the appropriate field of the certificate, such that an authenticating application can subsequently determine if the certificate is revoked. When the CA revokes a specific one of the issued certificates, it determines to which CRL the revoked certificate is assigned, and updates the specific CRL accordingly. In some embodiments, a single one of the multiple CRLs is active for assignment of certificates at any given time, and each certificate issued by the CA is assigned to the currently active CRL. In other embodiments, assignments of issued certificates are distributed between different ones of a pre-determined number of multiple CRLs by applying a statistical distribution formula to each issued certificate to determine a corresponding target CRL.

Abstract: The present invention provides anti-influenza A virus antibodies effective at binding, neutralizing, and treating influenza A H7N9 virus, compositions comprising such antibodies, and methods of using the same.

Abstract: The present invention provides anti-influenza B virus hemagglutinin antibodies, compositions comprising anti-influenza B virus hemagglutinin antibodies, and methods of using the same.

Abstract: The present invention provides anti-influenza B virus hemagglutinin antibodies, compositions comprising anti-influenza B virus hemagglutinin antibodies, and methods of using the same.

Abstract: The present invention provides anti-influenza A virus antibodies effective at binding, neutralizing, and treating influenza A H7N9 virus, compositions comprising such antibodies, and methods of using the same.

Abstract: The present invention provides anti-hemagglutinin antibodies, compositions comprising anti-hemagglutinin antibodies, and methods of using the same.

Abstract: A rigid polyurethane (PU) foam having a number average cell size of no greater than 10

Abstract: The present invention provides anti-hemagglutinin antibodies, compositions comprising anti-hemagglutinin antibodies, and methods of using the same.