Abstract: A two tier model for screening patients with sleep-disordered breathing includes collecting clinical information of a number of patients are collected, including gender, age, and body mass index, and performing form surveys including the Epworth Sleepiness Scale and the Snore Outcomes Survey to obtain a respiratory disturbance index (RDI). Receiver operating characteristics (ROC) are calculated with an initial strategy to maximize prediction sensitivity for patients with obstructive sleep apnea syndrome(OSAS). The associations between pulse oximeter data (desaturation index of 3%, DI3) against RDI was the second strategy to maximize prediction specificity.