Abstract: The disclosure features compositions and methods for the treatment of inner ear dysfunction, such as hearing loss or vestibular dysfunction, that reduce inflammatory or cell-mediated immune toxicity in the inner ear, thereby improving transduction and therapeutic efficacy. The disclosure provides a variety of compositions that include a nucleic acid vector that contains a polynucleotide encoding a therapeutic agent operably linked to a ubiquitous promoter and inhibitor of inflammatory or immune cell signaling. The disclosed compositions and methods can be used to increase expression of the therapeutic agent in a subject, such as a human subject suffering from an inner ear dysfunction, while minimizing undesirable immune activation resulting from off-target expression of the target protein in immune cells of the inner ear.

Abstract: Devices and methods that a first gate structure wrapping around a channel layer disposed over the substrate, a second gate structure wrapping around another channel layer disposed over the substrate and a dielectric fin structure formed over a shallow trench isolation (STI) feature and between the first and second gate structures. At least one metallization layer is formed on the first gate structure, the dielectric fin structure, and the second gate structure and contiguously extends from the first gate structure to the second gate structure.

Abstract: The present application relates to novel compounds that have modulating or activating effect on the activity of adenosine A3 receptor, preparation methods for the series of compounds, pharmaceutical compositions of the series of compounds, and pharmaceutical uses of the series of compounds.

Abstract: A method of fabricating a device includes forming a dummy gate over a plurality of fins. Thereafter, a first portion of the dummy gate is removed to form a first trench that exposes a first hybrid fin and a first part of a second hybrid fin. The method further includes filling the first trench with a dielectric material disposed over the first hybrid fin and over the first part of the second hybrid fin. Thereafter, a second portion of the dummy gate is removed to form a second trench and the second trench is filled with a metal layer. The method further includes etching-back the metal layer, where a first plane defined by a first top surface of the metal layer is disposed beneath a second plane defined by a second top surface of a second part of the second hybrid fin after the etching-back the metal layer.

Abstract: A method of forming a semiconductor device includes forming semiconductor strips protruding above a substrate and isolation regions between the semiconductor strips; forming hybrid fins on the isolation regions, the hybrid fins comprising dielectric fins and dielectric structures over the dielectric fins; forming a dummy gate structure over the semiconductor strip; forming source/drain regions over the semiconductor strips and on opposing sides of the dummy gate structure; forming nanowires under the dummy gate structure, where the nanowires are over and aligned with respective semiconductor strips, and the source/drain regions are at opposing ends of the nanowires, where the hybrid fins extend further from the substrate than the nanowires; after forming the nanowires, reducing widths of center portions of the hybrid fins while keeping widths of end portions of the hybrid fins unchanged, and forming an electrically conductive material around the nanowires.

Abstract: The present disclosure provides a chip packaging method and a chip packaging structure. The chip packaging method includes: providing an encapsulated grain and a packaging substrate, the encapsulated grain including a first hybrid bonding structure; wherein the packaging substrate includes a front side and a back side opposite to each other; a second hybrid bonding structure is formed on the front side of the packaging substrate and a connection pin is formed on the back side of the packing substrate; the second hybrid bonding structure and the connection pin are electrically connected through a third connecting metal column penetrating the packaging substrate; and bonding together the first hybrid bonding structure of the encapsulated grain and the second hybrid bonding structure of the packaging substrate by medium-to-medium and metal-to-metal aligned bonding such that the encapsulated grain is bonded to the packaging substrate.

Abstract: A surface-modified composite zinc-based negative electrode, a preparation method thereof, and a battery are provided. The composite zinc-based negative electrode includes a zinc matrix material, a nano inorganic metal/alloy modified layer, and an organic polymer protective layer. The nano inorganic metal/alloy modified layer can increase hydrogen evolution overpotential of the composite zinc-based negative electrode, inhibit the generation of hydrogen on the negative electrode surface and occurrence of side reactions. The organic polymer protective layer can enhance the zinc ion concentration and deposition uniformity at the electrode interface, and improve the dendrite problem caused by uneven zinc deposition-dissolution during the charging and discharging process. The application of the modified composite zinc-based negative electrode in aqueous zinc-based batteries can improve their cycling stability under high current and high utilization conditions and show good rate performance and cycling life.

Abstract: The present disclosure describes a semiconductor structure with a dielectric liner. The semiconductor structure includes a substrate and a fin structure on the substrate. The fin structure includes a stacked fin structure, a fin bottom portion below the stacked fin structure, and an isolation layer between the stacked fin structure and the bottom fin portion. The semiconductor structure further includes a dielectric liner in contact with an end of the stacked fin structure and a spacer structure in contact with the dielectric liner.

Abstract: A method for forming a gate all around transistor includes forming a plurality of semiconductor nanosheets. The method includes forming a cladding inner spacer between a source region of the transistor and a gate region of the transistor. The method includes forming sheet inner spacers between the semiconductor nanosheets in a separate deposition process from the cladding inner spacer.

Abstract: The present disclosure provides a method and device for constructing an autism spectrum disorder (ASD) risk prediction model. The method includes: establishing a first data table and a second data table based on case information of a sample set, obtaining a first grouped table set and a second grouped table set according to a preset characteristic arrangement rule and marker grouping rule, training data based on a random forest machine learning algorithm, and importing test data to obtain a first best characteristic combination and a second characteristic combination; and obtaining a first model based on the first best characteristic combination, stratified sampling of the first data table, and the random forest machine learning algorithm, obtaining a second model based on the second best characteristic combination, stratified sampling of the second data table, and the random forest machine learning algorithm, and performing combination to construct an ASD risk prediction model.

Abstract: This application relates to the field of wireless charging technologies. The wireless charging transmitting apparatus includes a transmit antenna array and a first controller. The wireless charging receiving apparatus includes a power receiving antenna and a second controller. When receiving a charging request signal, the first controller controls the transmit antenna array to successively switch to each polarization state to transmit a power signal. The second controller sends feedback information indicating a magnitude of energy obtained from the power signal. The first controller determines an optimal polarization state based on the feedback information, so that the transmit antenna array transmits a power signal in the optimal polarization state.

Abstract: Systems, devices, and methods of analyzing an interfered peak of a sample spectrum is disclosed. The sample spectrum may be generated using a detector of an optical spectrometer. The interfered peak may be produced by a plurality of spectral peaks of different wavelengths. The method may include generating interfered curve parameters representative of the peak shape of each spectral emission in the interfered peak based at least in part on a model of expected curve parameters for the optical spectrometer and a location of the interfered peak on the detector of the optical spectrometer; fitting a plurality of curves to the interfered peak, each curve corresponding to one of the plurality of spectral emissions of different wavelengths forming the interfered peak, wherein each curve is fitted using the interfered curve parameters provided by the model of expected peak parameters; and outputting the plurality of curves for further analysis.

Abstract: A wireless charging apparatus of a wireless charging system obtains, in a charging period, channel information of a transmission channel and a waveform parameter used to indicate a waveform of an electromagnetic wave signal; generates a target electromagnetic wave signal based on the channel information and the waveform parameter; and sends the target electromagnetic wave signal to a to-be-charged device through the transmission channel. The channel information includes signal attenuation and a transmission delay that are of an electromagnetic wave signal transmitted through the transmission channel. The to-be-charged device converts the received target electromagnetic wave signal into a direct current signal, and performs charging based on the direct current signal. The target electromagnetic wave signal determined by the wireless charging apparatus can adapt to channel transmission.

Abstract: A remote wireless charging transmit end is configured to wirelessly charge a receive end. The transmit end includes a transmit end processor, a fundamental frequency-radio frequency conversion unit, and a transmit end antenna. The transmit end processor is configured to generate a composite signal based on a control signal and a power signal, and send the composite signal to the fundamental frequency-radio frequency conversion unit. The control signal is used to control a working status of the receive end, and the power signal is used to charge the receive end. The fundamental frequency-radio frequency conversion unit is configured to convert the composite signal into a radio frequency signal, and send the radio frequency signal to the transmit end antenna. The transmit end antenna is configured to transmit the radio frequency signal corresponding to the composite signal.

Abstract: Techniques and apparatus are described for use in far-field wireless power transmitter. A far-field wireless power transmitter uses beamforming to localize a power signal transmitted from an array of antenna. A multi-tone signal is used for the power signal, where the signal transmitted from each of the antenna is formed of a plurality of tones having a frequency center and separated by a uniform frequency difference, and relative delays and/or relative amplitude differences are introduced into the signals from the different antennas of the array so that a beam is formed in a region where a far-field wireless power receiver's antenna is located. By use of two such transmitters placed to either side of the receiver, a hot-spot for the multi-tone power signal can be formed in the region of the receiver's antenna, with lower field values away from the region.

Abstract: Systems, methods, and non-transitory computer-readable media can receive at least one request for performing one or more operations, the request originating from a media application running on a media device, the request being broadcasted by the media device over a network to which the computing device is also connected. Information describing the request can be provided through a software application running on the computing device. A determination is made when user operating the computing device has approved the request. The operations are performed by at least the software application running on the computing device.

Abstract: A diffuse reflectance apparatus includes a housing having a window formed therein, and a diffuse reflectance mirror spaced from the window and having an aperture extending therethrough. A light source provides a beam of light. A first mirror assembly is positioned to reflect the beam of light through the aperture such that it passes through the window. A second mirror assembly is positioned to reflect scattered light from the concave mirror to a detector.

Abstract: A client device provides to a user, in an application associated with a social-networking service provided by a server system, a link to a page associated with a third-party service provider. The third-party service provider is distinct from the social-networking service. In response to user selection of the link, the page is loaded within the application. The page includes script for calling one or more application programming interfaces (APIs) of the server system. The client device calls the one or more APIs to obtain information associated with the user from the server system. The client device displays the page within the application, and uses the information associated with the user to conduct a transaction with the third-party service provider through the page.

Abstract: Embodiments of a notification framework for smart objects (e.g., smart televisions) to deliver notifications to user devices are described. In one embodiment, a method includes a smart device sending an event-registration request to a server, the event-registration request including event information associated with an event associated with the smart device. The smart device may receive a code generated by the server in response to the event-registration request, the code being associated with the event information. The smart device may send the code to a user device through short-range wireless communication. By using the code, the user device may obtain from the server the event information associated with the event of the smart device.