Abstract: Novel compounds of the structural formula (I), and the pharmaceutically acceptable salts thereof, are inhibitors of NLRP3 and may be useful in the treatment, prevention, management, amelioration, control and suppression of diseases mediated by NLPR3. The compounds of the present invention may be useful in the treatment, prevention or management of diseases, disorders and conditions mediated by NLRP3 such as, but not limited to, gout, pseudogout, CAPS, NASH fibrosis, heart failure, idiopathic pericarditis, atopic dermatitis, inflammatory bowel disease, Alzheimer's Disease, Parkinson's Disease and traumatic brain injury.

Abstract: Disclosed are a temporary plugging agent and a preparation method thereof, and a method for temporary plugging and fracturing of a high-temperature reservoir. The temporary plugging agent includes the following components in mass fractions: acrylamide 5%, composite crosslinking agent 1%, laponite 1%, ammonium persulfate 0.1% and water 92.9%.

Abstract: Disclosed are a temporary plugging agent and a preparation method thereof, and a method for temporary plugging and fracturing of a high-temperature reservoir. The temporary plugging agent includes the following components in mass fractions: acrylamide 5%, composite crosslinking agent 1%, laponite 1%, ammonium persulfate 0.1% and water 92.9%.

Abstract: A deep-sea submarine gas hydrate collecting method and a production house for the first time, the collecting method comprises the steps of: determining an active methane leakage zone near a landward limit of a submarine gas hydrate stability zone, acquiring submarine methane leakage in-situ observation data, determining a methane leakage rate and evaluating its economy; mounting a production house on the seabed, opening a monitoring system after the mounting, monitoring the submarine methane leakage condition and hydrate generation progress in real time, evaluating a hydrate generation amount, and performing hydrate acquisition work; and rapidly processing the gas hydrate in the house by a gas hydrate collecting system of an offshore platform, and continuously monitoring the methane leakage condition. A large amount of methane leaked can be collected, thereof, the method has dual meanings of resources and environment.

Abstract: A deep-sea submarine gas hydrate collecting method and a production house for the first time, the collecting method comprises the steps of: determining an active methane leakage zone near a landward limit of a submarine gas hydrate stability zone, acquiring submarine methane leakage in-situ observation data, determining a methane leakage rate and evaluating its economy; mounting a production house on the seabed, opening a monitoring system after the mounting, monitoring the submarine methane leakage condition and hydrate generation progress in real time, evaluating a hydrate generation amount, and performing hydrate acquisition work; and rapidly processing the gas hydrate in the house by a gas hydrate collecting system of an offshore platform, and continuously monitoring the methane leakage condition. A large amount of methane leaked can be collected, thereof, the method has dual meanings of resources and environment.

Abstract: The present disclosure relates to current geographical location displaying methods and devices. One example method includes detecting whether a user initiates an emergency call, in response to detecting that the user initiates an emergency call, obtaining current geographical location information, and presenting the current geographical location information on an emergency call screen. A presentation form comprises at least one of a text form and a map form.

Abstract: The invention provides a silk fibroin-based anti-counterfeiting mark comprising a silk fibroin film layer and a gold film layer located on the silk fibroin film layer, and the area of the gold film layer is less than that of the silk fibroin film layer. The inventive also provides a method for preparing the silk fibroin-based optical anti-counterfeiting mark, the method comprises preparing an aqueous silk fibroin solution, coating the aqueous silk fibroin solution onto a substrate to obtain a silk fibroin film, and sputtering a layer of gold film on the silk fibroin film with a mask to obtain the silk fibroin-based optical anti-counterfeiting mark. In the invention a thin layer of Au film is sputtered on a silk fibroin film such that an anti-counterfeiting mark pattern appears at a high humidity, the method is simple and can significantly the production cost of optical anti-counterfeiting mark.

Abstract: The invention provides a silk fibroin-based anti-counterfeiting mark comprising a silk fibroin film layer and a gold film layer located on the silk fibroin film layer, and the area of the gold film layer is less than that of the silk fibroin film layer. The inventive also provides a method for preparing the silk fibroin-based optical anti-counterfeiting mark, the method comprises preparing an aqueous silk fibroin solution, coating the aqueous silk fibroin solution onto a substrate to obtain a silk fibroin film, and sputtering a layer of gold film on the silk fibroin film with a mask to obtain the silk fibroin-based optical anti-counterfeiting mark. In the invention a thin layer of Au film is sputtered on a silk fibroin film such that an anti-counterfeiting mark pattern appears at a high humidity, the method is simple and can significantly the production cost of optical anti-counterfeiting mark.

Abstract: Compounds of Formula I: I and their pharmaceutically acceptable salts are useful for the inhibition of HIV reverse transcriptase. The compounds may also be useful for the prophylaxis or treatment of infection by HIV and in the prophylaxis, delay in the onset or progression, and treatment of AIDS. The compounds and their salts can be employed as ingredients in pharmaceutical compositions, optionally in combination with other antiviral agents, immunomodulators, antibiotics or vaccines.

Abstract: The present disclosure relates to current geographical location displaying methods and devices. One example method includes detecting whether a user initiates an emergency call, in response to detecting that the user initiates an emergency call, obtaining current geographical location information, and presenting the current geographical location information on an emergency call screen. A presentation form comprises at least one of a text form and a map form.

Abstract: Compounds of Formula I: I and their pharmaceutically acceptable salts are useful for the inhibition of HIV reverse transcriptase. The compounds may also be useful for the prophylaxis or treatment of infection by HV and in the prophylaxis, delay in the onset or progression, and treatment of AIDS. The compounds and their salts can be employed as ingredients in pharmaceutical compositions, optionally in combination with other antiviral agents, immunomodulators, antibiotics or vaccines.

Abstract: It is an object of the instant invention to provide a method for the rapid evaluation of novel sugar modifications to be used in siRNA synthesis including the rapid evaluation of chemical modification patterns within the siRNA to effectuate increased stability and ultimately increased efficacy of a siRNA therapeutic. It is a further object of the instant invention to provide novel nucleosides useful for siRNA therapy.

Abstract: It is an object of the instant invention to provide a method for the rapid evaluation of novel sugar modifications to be used in siRNA synthesis including the rapid evaluation of chemical modification patterns within the siRNA to effectuate increased stability and ultimately increased efficacy of a siRNA therapeutic. It is a further object of the instant invention to provide novel nucleosides useful for siRNA therapy.

Abstract: It is an object of the instant invention to provide a method for the rapid evaluation of novel sugar modifications to be used in siRNA synthesis including the rapid evaluation of chemical modification patterns within the siRNA to effectuate increased stability and ultimately increased efficacy of a siRNA therapeutic. It is a further object of the instant invention to provide novel nucleosides useful for siRNA therapy.

Abstract: It is an object of the instant invention to provide a method for the rapid evaluation of novel sugar modifications to be used in siRNA synthesis including the rapid evaluation of chemical modification patterns within the siRNA to effectuate increased stability and ultimately increased efficacy of a siRNA therapeutic. It is a further object of the instant invention to provide novel nucleosides useful for siRNA therapy.

Abstract: This invention relates to novel compounds and processes for their preparation, methods of treating diseases, particularly Cancer, comprising administering said compounds, and methods of making pharmaceutical compositions for the treatment or prevention of disorders, particularly Cancer.

Abstract: This invention relates to novel compounds and processes for their preparation, methods of treating diseases, particularly Cancer, comprising administering said compounds, and methods of making pharmaceutical compositions for the treatment or prevention of disorders, particularly Cancer.

Abstract: The present invention relates to heteroarylaminopyrazole compounds, pharmaceutical compositions, and methods for treating diabetes and related disorders.

Abstract: The present invention relates to heteroarylaminopyrazole compounds, pharmaceutical compositions, and methods for treating diabetes and related disorders.