Patents by Inventor Ning Qi
Ning Qi has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Publication number: 20250223290Abstract: Novel compounds of Formula (I), and the pharmaceutically acceptable salts thereof, are inhibitors of NLRP3 and may be useful in the treatment, prevention, management, amelioration, control and suppression of diseases mediated by NLPR3. The compounds of the present invention may be useful in the treatment, prevention or management of diseases, disorders and conditions mediated by NLRP3 such as, but not limited to, obesity, gout, pseudogout, CAPS, NASH, MASH, fibrosis, heart failure, idiopathic pericarditis, atopic dermatitis, inflammatory bowel disease, Alzheimer's Disease, Parkinson's Disease, dementia with Lewy bodies (DLB), and traumatic brain injury.Type: ApplicationFiled: December 12, 2024Publication date: July 10, 2025Applicant: Merck Sharp & Dohme LLCInventors: Zachary G. Brill, Donna A.A.W. Hayes, Tom M. Lam, Kyle S. McClymont, Bryan S. Matsuura, Rohan Rajiv Merchant, Anilkumar G. Nair, Ning Qi
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Publication number: 20250195511Abstract: Novel compounds of Formula (I), and the pharmaceutically acceptable salts thereof, are inhibitors of NLRP3 and may be useful in the treatment, prevention, management, amelioration, control, and suppression of diseases mediated by NLPR3. The compounds of the present invention may be useful in the treatment, prevention or management of diseases, disorders and conditions mediated by NLRP3 such as, but not limited to, obesity, gout, pseudogout, CAPS, NASH, MASH, fibrosis, osteoarthritis, atherosclerosis, heart failure, idiopathic pericarditis, myocarditis, atopic dermatitis, hidradenitis suppurativa, inflammatory bowel disease, cancer, Alzheimer's Disease, Parkinson's Disease, dementia with Lewy bodies (DLB), and traumatic brain injury.Type: ApplicationFiled: December 12, 2024Publication date: June 19, 2025Applicant: Merck Sharp & Dohme LLCInventors: Zachary G. Brill, Donna A.A.W. Hayes, Tom M. Lam, Kyle S. McClymont, Bryan S. Matsuura, Rohan Rajiv Merchant, Anilkumar G. Nair, Ning Qi
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Publication number: 20250105632Abstract: The present application provides a day-ahead scheduling method and apparatus for a power system, an electronic device, and a storage medium, where the method includes: obtaining power system prediction parameters in a to-be-scheduled time period, where the power system prediction parameters include thermal power unit parameters, renewable energy station parameters, load parameters, energy storage station (ESS) parameters, node parameters, a transmission line parameter and other power gird parameters; constructing a day-ahead scheduling optimization model and generating multiple renewable energy power scenarios based on the power system prediction parameters; solving the day-ahead scheduling optimization model to obtain day-ahead scheduling results; verifying the day-ahead scheduling results based on the power system prediction parameters and the multiple renewable energy power scenarios; and in case that the verifying the day-ahead scheduling results successes, outputting the day-ahead scheduling results.Type: ApplicationFiled: February 28, 2024Publication date: March 27, 2025Applicant: Tsinghua UniversityInventors: Feng LIU, Kai KANG, Ning QI, Yifan SU
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Publication number: 20250070568Abstract: The present application provides a unit commitment method for a power system and associated components, the method includes: determining a unit commitment value of the thermal power unit and a unit commitment value of the renewable energy unit obtained based on a pre-scheduling stage optimization model by considering an N?1 fault and frequency security of the power system; verifying the unit commitment value of the thermal power unit and the unit commitment value of the renewable energy unit based on a re-scheduling stage optimization model; when the verification successes, taking the unit commitment value of the thermal power unit and the unit commitment value of the renewable energy unit as a final unit commitment value; when the verification fails, updating the pre-scheduling stage optimization model and repeating the determining step and the verifying steps, making decisions to the unit commitment of the power system to obtain a unit commitment plan ensuring frequency security and power supply-demand balaType: ApplicationFiled: February 28, 2024Publication date: February 27, 2025Applicant: Tsinghua UniversityInventors: Feng LIU, Kai KANG, Yifan SU, Ning QI
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Publication number: 20240124451Abstract: Novel compounds of the structural formula (I), and the pharmaceutically acceptable salts thereof, are inhibitors of NLRP3 and may be useful in the treatment, prevention, management, amelioration, control and suppression of diseases mediated by NLPR3. The compounds of the present invention may be useful in the treatment, prevention or management of diseases, disorders and conditions mediated by NLRP3 such as, but not limited to, gout, pseudogout, CAPS, NASH fibrosis, heart failure, idiopathic pericarditis, atopic dermatitis, inflammatory bowel disease, Alzheimer's Disease, Parkinson's Disease and traumatic brain injury.Type: ApplicationFiled: September 21, 2023Publication date: April 18, 2024Applicant: Merck Sharp & Dohme LLCInventors: Donna A.A.W. Hayes, Prabha Karnachi, Madeleine Eileen Kieffer, Kyle S. McClymont, Rohan Rajiv Merchant, Essam Metwally, Anilkumar G. Nair, Ning Qi, Jillian Rose Sanzone, Nunzio Sciammetta, Emma H. Southgate, Zheng Tan, Brandon M. Taoka
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Patent number: 11945995Abstract: Disclosed are a temporary plugging agent and a preparation method thereof, and a method for temporary plugging and fracturing of a high-temperature reservoir. The temporary plugging agent includes the following components in mass fractions: acrylamide 5%, composite crosslinking agent 1%, laponite 1%, ammonium persulfate 0.1% and water 92.9%.Type: GrantFiled: December 15, 2020Date of Patent: April 2, 2024Assignee: CHINA UNIVERSITY OF PETROLEUMInventors: Tiankui Guo, Yuelong Zhang, Zengbao Wang, Ning Qi, Mingliang Luo, Feipeng Wu, Ming Chen, Xiaoqiang Liu, Jiwei Wang, Xiaozhi Wang, Yuanzhi Gong
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Publication number: 20220195284Abstract: Disclosed are a temporary plugging agent and a preparation method thereof, and a method for temporary plugging and fracturing of a high-temperature reservoir. The temporary plugging agent includes the following components in mass fractions: acrylamide 5%, composite crosslinking agent 1%, laponite 1%, ammonium persulfate 0.1% and water 92.9%.Type: ApplicationFiled: December 15, 2020Publication date: June 23, 2022Inventors: Tiankui GUO, Yuelong ZHANG, Zengbao WANG, Ning QI, Mingliang LUO, Feipeng WU, Ming CHEN, Xiaoqiang LIU, Jiwei WANG, Xiaozhi WANG, Yuanzhi GONG
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Patent number: 11313207Abstract: A deep-sea submarine gas hydrate collecting method and a production house for the first time, the collecting method comprises the steps of: determining an active methane leakage zone near a landward limit of a submarine gas hydrate stability zone, acquiring submarine methane leakage in-situ observation data, determining a methane leakage rate and evaluating its economy; mounting a production house on the seabed, opening a monitoring system after the mounting, monitoring the submarine methane leakage condition and hydrate generation progress in real time, evaluating a hydrate generation amount, and performing hydrate acquisition work; and rapidly processing the gas hydrate in the house by a gas hydrate collecting system of an offshore platform, and continuously monitoring the methane leakage condition. A large amount of methane leaked can be collected, thereof, the method has dual meanings of resources and environment.Type: GrantFiled: February 22, 2021Date of Patent: April 26, 2022Assignee: CHINA UNIVERSITY OF PETROLEUM (EAST CHINA)Inventors: Jinxiu Yang, Mingyue Lu, Shuangfang Lu, Min Wang, Ning Qi, Ying Xia, Shaogui Deng, Yong Chen, Zhoutuo Wei, Mingming Tang
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Publication number: 20220098958Abstract: A deep-sea submarine gas hydrate collecting method and a production house for the first time, the collecting method comprises the steps of: determining an active methane leakage zone near a landward limit of a submarine gas hydrate stability zone, acquiring submarine methane leakage in-situ observation data, determining a methane leakage rate and evaluating its economy; mounting a production house on the seabed, opening a monitoring system after the mounting, monitoring the submarine methane leakage condition and hydrate generation progress in real time, evaluating a hydrate generation amount, and performing hydrate acquisition work; and rapidly processing the gas hydrate in the house by a gas hydrate collecting system of an offshore platform, and continuously monitoring the methane leakage condition. A large amount of methane leaked can be collected, thereof, the method has dual meanings of resources and environment.Type: ApplicationFiled: February 22, 2021Publication date: March 31, 2022Inventors: Jinxiu YANG, Mingyue LU, Shuangfang LU, Min WANG, Ning QI, Ying XIA, Shaogui DENG, Yong CHEN, Zhoutuo WEI, Mingming TANG
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Patent number: 11109191Abstract: The present disclosure relates to current geographical location displaying methods and devices. One example method includes detecting whether a user initiates an emergency call, in response to detecting that the user initiates an emergency call, obtaining current geographical location information, and presenting the current geographical location information on an emergency call screen. A presentation form comprises at least one of a text form and a map form.Type: GrantFiled: November 3, 2016Date of Patent: August 31, 2021Assignee: Huawei Technologies Co., Ltd.Inventors: Ning Qi, Shiyong Cao
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Patent number: 10857830Abstract: The invention provides a silk fibroin-based anti-counterfeiting mark comprising a silk fibroin film layer and a gold film layer located on the silk fibroin film layer, and the area of the gold film layer is less than that of the silk fibroin film layer. The inventive also provides a method for preparing the silk fibroin-based optical anti-counterfeiting mark, the method comprises preparing an aqueous silk fibroin solution, coating the aqueous silk fibroin solution onto a substrate to obtain a silk fibroin film, and sputtering a layer of gold film on the silk fibroin film with a mask to obtain the silk fibroin-based optical anti-counterfeiting mark. In the invention a thin layer of Au film is sputtered on a silk fibroin film such that an anti-counterfeiting mark pattern appears at a high humidity, the method is simple and can significantly the production cost of optical anti-counterfeiting mark.Type: GrantFiled: July 25, 2016Date of Patent: December 8, 2020Assignee: NANTONG TEXTILE & SILK INDUSTRIAL TECHNOLOGY RESEARCH INSTITUTEInventors: Keqin Zhang, Qingsong Li, Yu Peng, Ning Qi, Xiaohua Zhang
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Publication number: 20200079133Abstract: The invention provides a silk fibroin-based anti-counterfeiting mark comprising a silk fibroin film layer and a gold film layer located on the silk fibroin film layer, and the area of the gold film layer is less than that of the silk fibroin film layer. The inventive also provides a method for preparing the silk fibroin-based optical anti-counterfeiting mark, the method comprises preparing an aqueous silk fibroin solution, coating the aqueous silk fibroin solution onto a substrate to obtain a silk fibroin film, and sputtering a layer of gold film on the silk fibroin film with a mask to obtain the silk fibroin-based optical anti-counterfeiting mark. In the invention a thin layer of Au film is sputtered on a silk fibroin film such that an anti-counterfeiting mark pattern appears at a high humidity, the method is simple and can significantly the production cost of optical anti-counterfeiting mark.Type: ApplicationFiled: July 25, 2016Publication date: March 12, 2020Inventors: Keqin ZHANG, Qingsong LI, Yu PENG, Ning QI, Xiaohua ZHANG
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Patent number: 10450335Abstract: Compounds of Formula I: I and their pharmaceutically acceptable salts are useful for the inhibition of HIV reverse transcriptase. The compounds may also be useful for the prophylaxis or treatment of infection by HIV and in the prophylaxis, delay in the onset or progression, and treatment of AIDS. The compounds and their salts can be employed as ingredients in pharmaceutical compositions, optionally in combination with other antiviral agents, immunomodulators, antibiotics or vaccines.Type: GrantFiled: December 12, 2016Date of Patent: October 22, 2019Assignee: Merck Sharp & Dohme Corp.Inventors: Wenlang Fu, Zhiqiang Guo, Ning Qi, Izzat T. Raheem, Petr Vachal, Ming Wang, John D. Schreier
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Publication number: 20190230476Abstract: The present disclosure relates to current geographical location displaying methods and devices. One example method includes detecting whether a user initiates an emergency call, in response to detecting that the user initiates an emergency call, obtaining current geographical location information, and presenting the current geographical location information on an emergency call screen. A presentation form comprises at least one of a text form and a map form.Type: ApplicationFiled: November 3, 2016Publication date: July 25, 2019Inventors: Ning QI, Shiyong CAO
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Publication number: 20180362563Abstract: Compounds of Formula I: I and their pharmaceutically acceptable salts are useful for the inhibition of HIV reverse transcriptase. The compounds may also be useful for the prophylaxis or treatment of infection by HV and in the prophylaxis, delay in the onset or progression, and treatment of AIDS. The compounds and their salts can be employed as ingredients in pharmaceutical compositions, optionally in combination with other antiviral agents, immunomodulators, antibiotics or vaccines.Type: ApplicationFiled: December 12, 2016Publication date: December 20, 2018Applicant: Merck Sharp & Dohme Corp.Inventors: Wenlang Fu, Zhiqiang Guo, Ning Qi, Izzat T. Raheem, Petr Vachal, Ming Wang, John D. Schreier
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Method for rapidly evaluating performance of short interfering RNA with novel chemical modifications
Patent number: 9512426Abstract: It is an object of the instant invention to provide a method for the rapid evaluation of novel sugar modifications to be used in siRNA synthesis including the rapid evaluation of chemical modification patterns within the siRNA to effectuate increased stability and ultimately increased efficacy of a siRNA therapeutic. It is a further object of the instant invention to provide novel nucleosides useful for siRNA therapy.Type: GrantFiled: October 3, 2014Date of Patent: December 6, 2016Assignee: SIRNA THERAPEUTICS, INC.Inventors: Gabor Butora, Ian W. Davies, William Michael Flanagan, Wenlang Fu, Denise M. Kenski, Ning Qi -
METHOD FOR RAPIDLY EVALUATING PERFORMANCE OF SHORT INTERFERING RNA WITH NOVEL CHEMICAL MODIFICATIONS
Publication number: 20150132761Abstract: It is an object of the instant invention to provide a method for the rapid evaluation of novel sugar modifications to be used in siRNA synthesis including the rapid evaluation of chemical modification patterns within the siRNA to effectuate increased stability and ultimately increased efficacy of a siRNA therapeutic. It is a further object of the instant invention to provide novel nucleosides useful for siRNA therapy.Type: ApplicationFiled: October 3, 2014Publication date: May 14, 2015Inventors: Gabor Butora, Ian W. Davies, William Michael Flanagan, Wenlang Fu, Denise M. Kenski, Ning Qi -
Method for rapidly evaluating performance of short interfering RNA with novel chemical modifications
Patent number: 8877439Abstract: It is an object of the instant invention to provide a method for the rapid evaluation of novel sugar modifications to be used in siRNA synthesis including the rapid evaluation of chemical modification patterns within the siRNA to effectuate increased stability and ultimately increased efficacy of a siRNA therapeutic. It is a further object of the instant invention to provide novel nucleosides useful for siRNA therapy.Type: GrantFiled: December 9, 2010Date of Patent: November 4, 2014Assignee: Sirna Therapeutics, Inc.Inventors: Gabor Butora, Ian W. Davies, William Michael Flanagan, Wenlang Fu, Denise M. Kenski, Ning Qi -
Method For Rapidly Evaluating Performance Of Short Interfering RNA With Novel Chemical Modifications
Publication number: 20120252027Abstract: It is an object of the instant invention to provide a method for the rapid evaluation of novel sugar modifications to be used in siRNA synthesis including the rapid evaluation of chemical modification patterns within the siRNA to effectuate increased stability and ultimately increased efficacy of a siRNA therapeutic. It is a further object of the instant invention to provide novel nucleosides useful for siRNA therapy.Type: ApplicationFiled: December 9, 2010Publication date: October 4, 2012Inventors: Gabor Butora, Ian W. Davies, William Michael Flanagan, Wenlang Fu, Denise M. Kenski, Ning Qi -
Patent number: 8138336Abstract: This invention relates to novel compounds and processes for their preparation, methods of treating diseases, particularly Cancer, comprising administering said compounds, and methods of making pharmaceutical compositions for the treatment or prevention of disorders, particularly Cancer.Type: GrantFiled: September 22, 2008Date of Patent: March 20, 2012Assignee: Bayer HealthCare LLCInventors: Steven Magnuson, Philip Wickens, Zhonghua Zhang, Ning Qi, Xin Ma