Abstract: The present disclosure relates to compounds of formula (I) and their anti-tumor uses, and their intermediates of formula (III), and uses of the intermediates. The compound of formula (I) has a degrading effect on a specific target protein, which is mainly composed of three parts. The first part is a small molecule compound (SMBP, Small Molecules Binding Protein) that can bind to a protein, the second part LIN is a linker, and the three-part ULM is a ubiquitin ligand (ULM, Ubiquitin Ligase Binding Moiety), wherein SMBP is covalently bound to LIN, and LIN is covalently bound to ULM. A series of compounds designed and synthesized in the present disclosure have a wide range of pharmacological activities, including the functions of degrading specific proteins and/or inhibiting activities of specific proteins, and thus can be used in related tumor treatments.

Abstract: The disclosure provides methods of characterizing a sample of oligonucleotides of interest using liquid chromatography and mass spectrometry.

Abstract: The present disclosure relates to compounds of formula (I) and their anti-tumor uses, and their intermediates of formula (III), intermediates of formula (IV), and uses of the intermediates. The compound of formula (I) has a degrading effect on a specific target protein, which is mainly composed of three parts. The first part is a small molecule compound (SMBP, Small Molecules Binding Protein) that can bind to a protein, the second part LIN is a linker, and the three-part ULM is a ubiquitin ligand (ULM, Ubiquitin Ligase Binding Moiety), wherein SMBP is covalently bound to LIN, and LIN is covalently bound to ULM. A series of compounds designed and synthesized in the present disclosure have a wide range of pharmacological activities, including the functions of degrading specific proteins and/or inhibiting activities of specific proteins, and thus can be used in related tumor treatments.

Abstract: Provided herein are KRAS G12D proteolysis targeting chimeras (PROTACs), compositions comprising the KRAS G12D PROTACs, and methods of making and using the KRAS G12D PROTACs, e.g., to promote degradation of KRAS G12D and/or treat KRAS G12D-associated cancers. In an embodiment, the KRAS G12D PROTAC has the following structural formula: [KRAS G12Di]-L?-[Degron], or a pharmaceutically acceptable salt thereof, wherein values for the variables (e.g., KRAS G12Di, L?, Degron) are as described herein.

Abstract: A robotic welding device including a control box configured to pre-store various welding processes and generate a welding parameter. A wire feed mechanism configured to feed a welding wire to a welding gun and a flexible guide rail attached to a welding component. A welding robot including a robot body and a welding gun. A teaching apparatus in communication with the welding robot and the control box, controlling, a traveling path and an operation position of the welding robot, and adjusting oscillation and welding operations of the welding gun according to an instruction of the control box. A remote control terminal in communication with the control box, and in communication with a data acquisition device of the welding robot. The robotic welding device including a welding power supply.

Abstract: A self-cleaning and anti-adhesion apparatus for marine instruments includes an installation frame. A first end of the installation frame is fixed with an installation base, and a second end of the installation frame is movable with a screw rod. The upper end of the installation base is movable with a first rotation base. A wire netting ball used for holding a sensor is installed above the first rotation base. The wire netting ball is fixedly connected with the installation base. The top end of the screw rod is fixedly connected with a first end of the flexible connector, and a second end of the flexible connector is fixedly connected with a floating bladder. The screw rod is screwed with an inner wheel of an internal meshing ratchet mechanism, and an outer wheel of the internal meshing ratchet mechanism is fixed inside the mounting ring.

Abstract: A self-cleaning and anti-adhesion apparatus for marine instruments includes an installation frame. A first end of the installation frame is fixed with an installation base, and a second end of the installation frame is movable with a screw rod. The upper end of the installation base is movable with a first rotation base. A wire netting ball used for holding a sensor is installed above the first rotation base. The wire netting ball is fixedly connected with the installation base. The top end of the screw rod is fixedly connected with a first end of the flexible connector, and a second end of the flexible connector is fixedly connected with a floating bladder. The screw rod is screwed with an inner wheel of an internal meshing ratchet mechanism, and an outer wheel of the internal meshing ratchet mechanism is fixed inside the mounting ring.

Abstract: A grounding segment for a segmented grounding electric device, including a plurality of segment single bodies disposed in a matched manner, wherein a curved concave surface is formed in an outer side surface of each segment single body; a chute is formed in the curved concave surface; an interior of the chute is in sliding connection with an elastic member; two ends of the elastic member are respectively connected to sliders; the sliders are in sliding connection with the interior of the chute; each slider is movably connected to a curved fixing member matching a grounding conductor; the curved fixing member is made of a conductive material applicable to grounding conductors of different sizes; and a locking apparatus is connected between the plurality of segment single bodies. A user conveniently transports and mounts the grounding segment to reduce a land excavation area. Universality of the grounding segment is improved.

Abstract: A grounding segment for a segmented grounding electric device, including a plurality of segment single bodies disposed in a matched manner, wherein a curved concave surface is formed in an outer side surface of each segment single body; a chute is formed in the curved concave surface; an interior of the chute is in sliding connection with an elastic member; two ends of the elastic member are respectively connected to sliders; the sliders are in sliding connection with the interior of the chute; each slider is movably connected to a curved fixing member matching a grounding conductor; the curved fixing member is made of a conductive material applicable to grounding conductors of different sizes; and a locking apparatus is connected between the plurality of segment single bodies. A user conveniently transports and mounts the grounding segment to reduce a land excavation area. Universality of the grounding segment is improved.

Abstract: Disclosed are a multipath selection method and device, and a storage medium. The method includes that: a correlation sequence between a received signal and a local reference signal is acquired by means of a correlation calculation method; a power spectrum of the correlation sequence and an average noise power of the received signal are acquired; according to the average noise power of the received signal, the power spectrum of the correlation sequence is divided into at least one first multipath component area and a second multipath component area according to a pre-set dividing rule; the at least one first multipath component area is searched according to a pre-set first noise threshold, so as to acquire a valid multipath component signal in the at least one first multipath component area; and the second multipath component area is searched according to a pre-set second noise threshold, so as to acquire a valid multipath component signal in the second multipath component area.

Abstract: The present disclosure discloses a method and device for determining a position, and a computer storage medium. The method includes that a first power value for a SYNC-NL segment within a DwPTS, a second power value for a first GP segment which precedes the SYNC-NL segment, a third power value for a second GP segment which follows the SYNC-NL segment, and a fourth power value for a time slot 0 are acquired; an eigenvalue of the DwPTS is calculated according to the first power value, the second power value, the third power value and the fourth power value; and the position of the DwPTS is determined according to the eigenvalue.

Abstract: An MAP algorithm-based Turbo decoding method and apparatus. The method includes: iteratively estimating an information symbol by using an MAP algorithm, acquiring an ? and ? window boundary values of each sliding window by means of window boundary value inheritance, acquiring an ? block boundary value and ? block boundary value of each sub-block by means of block boundary value inheritance, and recursively calculating posterior probability Log Likelihood Ratio (LLR) values of a whole window and a whole block according to the ? boundary values and the ? boundary values (101); and performing decoding decision according to the LLR values (102).

Abstract: Disclosed are a multipath selection method and device, and a storage medium. The method includes that: a correlation sequence between a received signal and a local reference signal is acquired by means of a correlation calculation method; a power spectrum of the correlation sequence and an average noise power of the received signal are acquired; according to the average noise power of the received signal, the power spectrum of the correlation sequence is divided into at least one first multipath component area and a second multipath component area according to a pre-set dividing rule; the at least one first multipath component area is searched according to a pre-set first noise threshold, so as to acquire a valid multipath component signal in the at least one first multipath component area; and the second multipath component area is searched according to a pre-set second noise threshold, so as to acquire a valid multipath component signal in the second multipath component area.

Abstract: Disclosed is an MAP algorithm-based Turbo decoding method and apparatus. The method includes: iteratively estimating an information symbol by using an MAP algorithm, acquiring an ? and ? window boundary values of each sliding window by means of window boundary value inheritance, acquiring an ? block boundary value and ? block boundary value of each sub-block by means of block boundary value inheritance, and recursively calculating posterior probability Log Likelihood Ratio (LLR) values of a whole window and a whole block according to the ? boundary values and the ? boundary values (101); and performing decoding decision according to the LLR values (102).

Abstract: Disclosed are a signal gain control method and device for a TD-HSPA+ terminal device. The method comprises the following steps: when a terminal device is in a continuous packet transmission mode, it is determined whether the terminal device receives a signal from a high speed packet channel for the first time, and if not, it is determined whether a reception interval between two successively received signals is smaller than a preset interval; if the reception interval is not smaller than the preset interval, a gain AGCPCCPCH at a main frequency point of a primary common control physical channel (PCCPCH) of a cell is obtained, and the AGCPCCPCH is used to control a gain of a signal currently received by the terminal device.

Abstract: The present disclosure discloses a method and device for determining a position, and a computer storage medium. The method includes that a first power value for a SYNC-NL segment within a DwPTS, a second power value for a first GP segment which precedes the SYNC-NL segment, a third power value for a second GP segment which follows the SYNC-NL segment, and a fourth power value for a time slot 0 are acquired; an eigenvalue of the DwPTS is calculated according to the first power value, the second power value, the third power value and the fourth power value; and the position of the DwPTS is determined according to the eigenvalue.