Abstract: Segmentation of an image into individual body parts is performed based on a trained model. The model is trained with a plurality of training images, each training image representing a corresponding training figure. The model is also trained with a corresponding plurality of segmentations of the training figures. Each segmentation is generated by positioning body parts between defined positions of joints of the represented figure. The body parts are represented by body part templates obtained from a template library, with the templates defining characteristics of body parts represented by the templates.

Abstract: A method for recycling polyester/polyurethane is provided. The method comprises adding additives containing hydroxyl or/and amino groups to polyester/polyurethane waste and performing transesterification or transcarbamoylation at 80-180° C. to form recycled new materials with different structures including polyester, polyurethane, polyamide, and polyurea.

Abstract: Disclosed herein are methods for identifying a ubiquitin ligase agonist, and the methods include (a) contacting a ubiquitin ligase with a candidate agonist and a neo-substrate; and (b) determining whether the candidate agonist is effective to result in binding the ubiquitin ligase to the neo-substrate, wherein binding of the ubiquitin substrate to the neo-substrate identifies the candidate agonist as a ubiquitin ligase agonist.

Abstract: The present disclosure provides a method to fabricate three-dimensional transparent glass utilizing polymer plasticity, including the following steps. In step 1, synthesize polymer-glass powder composite containing dynamic chemical bonds, the bond exchange catalyst is added during the synthesis process, and then cure to obtain a two-dimensional sheet shape I, the bond exchange catalyst is used to activate a dynamic chemical bond in step 2. In step 2, shape the two-dimensional sheet shape I obtained in step 1 into a complex three-dimensional shape II under the conditions of the effect of an external force and the activable dynamic chemical bond. In step 3, pyrolyze the composite precursor at high temperature to obtain transparent glass with complex three-dimensional shape II. The present disclosure provides a method in shaping the transparent glass with complex geometries by unique polymer plasticity in lower temperature.

Abstract: A fabrication method and application of topological elastomers with highly branched structures, low modulus and high elasticity. The topological elastomers comprise dendritic macromolecules. The fabrication method includes direct crosslinking, post-crosslinking, grafting, and copolymerization. The performance of the elastomer can be easily tuned via changing the topology of the polymer network. The breakthrough of this invention lies in that these topological elastomers with highly branched structures are having low modulus and high elasticity, which would expand its application in the field of elastomer. Notably, the variety of topological elastomers, the versatility of curing chemistries, the availability of a wide variety of monomers, and the various polymerization methods are enabling the fabrication of topological elastomers with feasibility and efficiency.

Abstract: The present invention relates to a system for F-box hormone receptor regulated protein expression in mammalian cells. The system includes a silencing nucleic acid molecule comprising a first promoter and an shRNA operably linked to the first promoter, where the shRNA silences expression of a target protein. The system also includes an expression nucleic acid molecule comprising a second promoter, an F-box hormone receptor operably linked to the second promoter, and a nucleic acid molecule encoding a fusion protein comprising a degron fused to the target protein, where the nucleic acid molecule encoding the fusion protein is operably linked to the second promoter. Also disclosed are vectors comprising the system of the present application and methods of use thereof.

Abstract: E3 ubiquitin ligase agonists, pharmaceutical compositions including the E3 ubiquitin ligase agonists, and related methods of use are described.

Abstract: Screening assays and related reagent kits for characterizing an ability of a candidate compound to modulate a binding affinity between a mutant F-box/WD repeat-containing protein 7 (FBW7) peptide and an FBW7 substrate are described.

Abstract: A three-dimensional printing system includes a resin vessel containing resin, an imaging bar, a movement mechanism coupled to the imaging bar, and a controller. The imaging bar includes an arrangement of light emitting devices that selectively emit radiation from an exit surface of the imaging bar to define a build plane in the resin. The exit surface of the imaging bar is preferably less than 10 millimeters from the build plane. The controller is configured to scan the imaging bar along a scan axis and, concurrent with scanning, operate the imaging bar to selectively image a layer of resin at the build plane.

Abstract: The present invention relates to a system for F-box hormone receptor regulated protein expression in mammalian cells. The system includes a silencing nucleic acid molecule comprising a first promoter and an shRNA operably linked to the first promoter, where the shRNA silences expression of a target protein. The system also includes an expression nucleic acid molecule comprising a second promoter, an F-box hormone receptor operably linked to the second promoter, and a nucleic acid molecule encoding a fusion protein comprising a degron fused to the target protein, where the nucleic acid molecule encoding the fusion protein is operably linked to the second promoter. Also disclosed are vectors comprising the system of the present application and methods of use thereof.

Abstract: Systems and techniques are provided for aggregation of asynchronous trust outcomes in a mobile device. Trust levels may be determined from the signals. Each trust level may be determined independently of any other trust level. Each trust level may be determined based on applying to the signals heuristics, mathematical optimization, decisions trees, machine learning systems, or artificial intelligence systems. An aggregated trust outcome may be determined by aggregating the trust levels. Aggregating the trust levels may include applying heuristics, mathematical optimization, decisions trees, machine learning systems, or artificial intelligence systems to the trust levels, and wherein the aggregated trust outcome; and sending the aggregated trust outcome to be implemented by the enabling, disabling, or relaxing of at least one security measure based on the aggregated trust outcome.

Abstract: Systems and techniques are provided for aggregation of asynchronous trust outcomes in a mobile device. Trust levels may be determined from the signals. Each trust level may be determined independently of any other trust level. Each trust level may be determined based on applying to the signals heuristics, mathematical optimization, decisions trees, machine learning systems, or artificial intelligence systems. An aggregated trust outcome may be determined by aggregating the trust levels. Aggregating the trust levels may include applying heuristics, mathematical optimization, decisions trees, machine learning systems, or artificial intelligence systems to the trust levels, and wherein the aggregated trust outcome; and sending the aggregated trust outcome to be implemented by the enabling, disabling, or relaxing of at least one security measure based on the aggregated trust outcome.

Abstract: A system, method and program product for implementing an LSM tree data store in a storage infrastructure. A system is disclosed having: a system for handling read requests and write requests using a key-value pair index to store and retrieve data in an LSM data store; and a compaction manager that reorganizes data in the LSM data store using: a partition system that (a) partitions a first level file into a set of subfiles when a partition threshold is exceeded, and (b) stores the subfiles from the first level file in an intermediate level between the first level and a second level, wherein the subfiles are partitioned by range to correspond with files in the second level; and a merge system that merges a group of files comprising a second level file with one or more corresponding subfiles when a merge threshold is exceeded.

Abstract: Systems and techniques are provided for aggregation of asynchronous trust outcomes in a mobile device. Trust levels may be determined from the signals. Each trust level may be determined independently of any other trust level. Each trust level may be determined based on applying to the signals heuristics, mathematical optimization, decisions trees, machine learning systems, or artificial intelligence systems. An aggregated trust outcome may be determined by aggregating the trust levels. Aggregating the trust levels may include applying heuristics, mathematical optimization, decisions trees, machine learning systems, or artificial intelligence systems to the trust levels, and wherein the aggregated trust outcome; and sending the aggregated trust outcome to be implemented by the enabling, disabling, or relaxing of at least one security measure based on the aggregated trust outcome.

Abstract: A system and method for correcting colors in an image in order to identify pills. The system includes a surface that includes a background upon which pills are positioned and a border of known color adjacent to the background. The system also includes a digital camera and a processor. The processor is used to receive and process the image, use target objects on the surface to identify areas of the image that correspond to the known characteristics and features of the surface, perform image diagnostics to determine if the image can be used, and correct image color based on comparison of identified areas of the image that correspond with the known characteristics and features of the surface. Various graphical displays or cues can assist a user in obtaining a usable image.

Abstract: Coronatine has been found to enhance binding of the JAZ1 degron to the Arabidopsis F-box protein COI1, and analysis of the JAZ1 degron sequence has resulted in the identification of specific peptide sequences that bind COI1 with high affinity in the presence of coronatine. Crystal structure analysis has determined that coronatine and JA-Ile enhance the interaction between COI1 and JAZ1 via binding to a specific binding pocket on COI1. Attachment of one or more JAZ1 peptide tags as disclosed herein to a target protein in a non-plant cell expressing Arabidopsis COI1 or a homolog thereof results in degradation of the target protein following addition of a molecule that binds the coronatine/JA-Ile binding pocket on COI1. Therefore, provided herein are compositions, methods, and kits for targeted protein degradation.

Abstract: Systems and techniques are provided for aggregation of asynchronous trust outcomes in a mobile device. Trust levels may be determined from the signals. Each trust level may be determined independently of any other trust level. Each trust level may be determined based on applying to the signals heuristics, mathematical optimization, decisions trees, machine learning systems, or artificial intelligence systems. An aggregated trust outcome may be determined by aggregating the trust levels. Aggregating the trust levels may include applying heuristics, mathematical optimization, decisions trees, machine learning systems, or artificial intelligence systems to the trust levels, and wherein the aggregated trust outcome; and sending the aggregated trust outcome to be implemented by the enabling, disabling, or relaxing of at least one security measure based on the aggregated trust outcome.

Abstract: A data storage device is disclosed wherein a first 2D data dependent noise whitening (DDNW) filter is configured to perform 2D DDNW of first and second 2D equalized samples to generate first 2D noise whitened samples. A second 2D DDNW filter is configured to perform 2D DDNW of the first and second 2D equalized samples to generate second 2D noise whitened samples. A 2D sequence detector is configured to detect a first data sequence recorded in a first data track from the first and second 2D noise whitened samples and to detect a second data sequence recorded in a second data track from the first and second 2D noise whitened samples.

Abstract: A system and method for correcting colors in an image in order to identify pills. The system includes a surface that includes a background upon which pills are positioned and a border of known color adjacent to the background. The system also includes a digital camera and a processor. The processor is used to receive and process the image, use target objects on the surface to identify areas of the image that correspond to the known characteristics and features of the surface, perform image diagnostics to determine if the image can be used, and correct image color based on comparison of identified areas of the image that correspond with the known characteristics and features of the surface. Various graphical displays or cues can assist a user in obtaining a usable image.

Abstract: A system and method for correcting colors in an image in order to identify pills. The system includes a surface that includes a background upon which pills are positioned and a border of known color adjacent to the background. The system also includes a digital camera and a processor. The processor is used to receive and process the image, use target objects on the surface to identify areas of the image that correspond to the known characteristics and features of the surface, perform image diagnostics to determine if the image can be used, and correct image color based on comparison of identified areas of the image that correspond with the known characteristics and features of the surface. Various graphical displays or cues can assist a user in obtaining a usable image.