Patents by Inventor Ningbo AN

Ningbo AN has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Publication number: 20120035855
    Abstract: The invention provides a network-based method for confirming drug action (drug effect, synergistic reaction). The method be carried out by mapping a first drug genes/gene products subset and a second genes/gene products subset in a gene network. The second genes/gene products subset can be a second drug genes/gene products subset or a biological process genes/gene products subset. The invention also provides a tool for pre-clinical drug screening.
    Type: Application
    Filed: October 9, 2009
    Publication date: February 9, 2012
    Inventors: Shao Li, Ningbo Zhang
  • Patent number: 8112230
    Abstract: A method for determining synergistic effect of a medicine combination including two medicines relating to a disease on the basis of a gene network and medicine-effective genes of each and/or any of said two medicines, comprising: determining a synergy factor (ST1,2) of two medicines on the basis of distribution of medicine-effective genes of two medicines; determining a medicine similarity factor (AS1,2) of two medicines on the basis of similarity between a set of symptoms which two medicines relates to; and, determining synergistic effect of two medicines according to a product of the synergy factor and similarity factor. Proposed is constructing a disease-related gene network, mapping medicine-effective genes onto the network, and determining the synergistic effect of medicines on the basis of the genes. The present invention also relates to medicine composition of sinomenine and honokiol and of sinomenine and luteolin, each with anti-angiogenesis effect and having good synergistic effect.
    Type: Grant
    Filed: May 7, 2009
    Date of Patent: February 7, 2012
    Inventors: Ningbo Zhang, Shao Li, Bo Zhang
  • Publication number: 20100144777
    Abstract: A method was provided for determining synergistic effect of a medicine combination including two medicines relating to a disease on the basis of a gene network and medicine-effective genes of each and/or any of said two medicines, comprising: determining a synergy factor (ST1,2) of said two medicines on the basis of distribution of medicine-effective genes of said two medicines; determining a medicine similarity factor (AS1,2) of said two medicines on the basis of similarity between set of symptoms which said two medicines relates to; and, determining extent of synergistic effect of said two medicines according to a product of said synergy factor and said similarity factor.
    Type: Application
    Filed: May 7, 2009
    Publication date: June 10, 2010
    Inventors: Shao Li, Ningbo Zhang, Bo Zhang