Abstract: A method for determining synergistic effect of a medicine combination including two medicines relating to a disease on the basis of a gene network and medicine-effective genes of each and/or any of said two medicines, comprising: determining a synergy factor (ST1,2) of two medicines on the basis of distribution of medicine-effective genes of two medicines; determining a medicine similarity factor (AS1,2) of two medicines on the basis of similarity between a set of symptoms which two medicines relates to; and, determining synergistic effect of two medicines according to a product of the synergy factor and similarity factor. Proposed is constructing a disease-related gene network, mapping medicine-effective genes onto the network, and determining the synergistic effect of medicines on the basis of the genes. The present invention also relates to medicine composition of sinomenine and honokiol and of sinomenine and luteolin, each with anti-angiogenesis effect and having good synergistic effect.

Abstract: A method was provided for determining synergistic effect of a medicine combination including two medicines relating to a disease on the basis of a gene network and medicine-effective genes of each and/or any of said two medicines, comprising: determining a synergy factor (ST1,2) of said two medicines on the basis of distribution of medicine-effective genes of said two medicines; determining a medicine similarity factor (AS1,2) of said two medicines on the basis of similarity between set of symptoms which said two medicines relates to; and, determining extent of synergistic effect of said two medicines according to a product of said synergy factor and said similarity factor.