Abstract: Disclosed is an integrated urine anaerobic collection and culture apparatus, comprising: a catheter, at a front end of which a circular arc-shaped guide part and a first through hole are arranged, where a piston part is arranged inside the front end of the catheter; a first branch tube and a second branch tube, which are connected with the catheter, the first branch tube is connected with a first negative pressure vessel, and the first branch tube and the second branch tube are respectively provided with a first valve and a second valve; an aseptic centrifuge tube, which includes a tube body and a first cover body, where the first cover body is provided with a first check valve and a second check valve; a second negative pressure vessel. The present disclosure can realize the whole anaerobic operation of urine collection and culture in the bladder.

Abstract: This invention discloses a method and system for the segmentation and clustering of nuclei based on single-cell pathological images. The contour tracing method is used to calculate all the closed contours existing in the pathological tissue images; and optimizes the contours to obtain the segmented images of the nuclei. Then, according to the mask image corresponding to the segmented images of the nuclei, the segmented images of the nuclei are divided into individual nucleus images; the influencing features of the nuclei in the corresponding area are extracted through the mask image; through feature selection, redundant features are removed, and then the UMAP feature reduction method is used to select the two most important features for clustering the nuclei. By first segmenting and dividing the nucleus area in the pathological images, and then using the divided single nucleus for feature extraction, the basis for clustering is made more objective.

Abstract: The disclosure discloses a fatty acid synthase inhibitor and application thereof and belongs to the technical field of medical biology. The fatty acid synthase inhibitor of the disclosure can significantly inhibit the activity of fatty acid synthase without affecting normal expression, and adjust the ratio of fatty acids in cells. The fatty acid synthase inhibitor of the disclosure has a good tumor proliferation inhibitory effect, can arrest the growth cycle of tumor cells in the interphase, prevent tumor cell division, inhibit tumor cell proliferation, promote tumor cell apoptosis and exert a tumor treatment effect, can be used to treat tumors and metabolism related diseases, and has an important clinical application prospect.

Abstract: A segmentation method for tumor regions in a pathological image of clear cell renal cell carcinoma based on deep learning includes data acquisition and pre-processing, building and training of a classification network SENet and prediction of tumor regions. The present invention studies clear cell renal cell carcinoma based on pathological images, yielding results with higher reliability than judgments made based on CT or MRI images. The present invention overcomes the drawback that the previous research on clear cell renal cell carcinoma is only limited to judgment on presence by being able to visually provide the position and size of tumor regions, which is convenient for the medical profession to better study the pathogenesis and directions to the treatment of clear cell renal cell carcinoma.

Abstract: The disclosure discloses a fatty acid synthase inhibitor and application thereof and belongs to the technical field of medical biology. The fatty acid synthase inhibitor of the disclosure can significantly inhibit the activity of fatty acid synthase without affecting normal expression, and adjust the ratio of fatty acids in cells. The fatty acid synthase inhibitor of the disclosure has a good tumor proliferation inhibitory effect, can arrest the growth cycle of tumor cells in the interphase, prevent tumor cell division, inhibit tumor cell proliferation, promote tumor cell apoptosis and exert a tumor treatment effect, can be used to treat tumors and metabolism related diseases, and has an important clinical application prospect.