Abstract: Provided are a fused bicyclic heteroaryl amide compound as a protein aggregation inhibitor, as well as the use of such compound in the treatment or prevention of neurodegenerative diseases characterized by protein aggregation, such as Alzheimer's disease, Parkinson's disease, frontotemporal dementia, dementia with Lewy bodies, Parkinson's disease dementia, multiple system atrophy, amyotrophic lateral sclerosis, Huntington's disease, and cancer.

Abstract: The present invention belongs to the technical field of new use of medicines, and provides use of a medicine for reducing the iron content in brain in the preparation of a drug for treating and/or preventing neuropsychiatric diseases. The present invention provides a medicine/diet for reducing the iron content, which prevents the development of substance addiction behavior after administration, to prevent and treat substance addiction or dependence. The medicine is a hypoxia-inducible factor prolyl hydroxylase inhibitor or an iron chelating agent.

Abstract: A section of a node of the station is a section with an arch roof and a straight wall of three underground floors, a first underground floor is a station hall floor 1, and a second underground floor is a platform floor 2 of a subway line A and a third underground floor is a platform floor 3 of a subway line B; and directions of the subway line A and the subway line B are orthogonal. Second lining structures of the first and second underground floors are firstly constructed, and after a shield tunneling machine is pushed through the station, the structure of the third underground floor is constructed by a reverse construction method. Thus, the present disclosure is conducive to improving the efficiency of overall construction, guaranteeing timely tunnel construction completion of two lines and hence timely track construction completion and electricity wiring completion.

Abstract: A method for constructing a large-span station by two-wing open type semi-covered excavation and semi-reverse construction, is divided into three stages of excavation. First, excavate a first-stage inner small foundation pit, then excavate a second-stage annular foundation pit within the first-stage retaining piles and outside the range of the first-stage inner small foundation pit, and finally excavate a third-stage semi-covered excavation foundation pit below the first-stage inner small foundation pit and the second-stage annular foundation pit. By setting graded retaining piles, middle upright post piles, middle top plates, local waist beams and local concrete supports in the soil-rock combination strata, so that the force transfer between the foundation pit enclosure and the station main body structures and the underlying rock layer is clear and reliable, and a stable frame structure is achieved.

Abstract: A method for constructing a large-span station by two-wing open type semi-covered excavation and semi-reverse construction, is divided into three stages of excavation. First, excavate a first-stage inner small foundation pit, then excavate a second-stage annular foundation pit within the first-stage retaining piles and outside the range of the first-stage inner small foundation pit, and finally excavate a third-stage semi-covered excavation foundation pit below the first-stage inner small foundation pit and the second-stage annular foundation pit. By setting graded retaining piles, middle upright post piles, middle top plates, local waist beams and local concrete supports in the soil-rock combination strata, so that the force transfer between the foundation pit enclosure and the station main body structures and the underlying rock layer is clear and reliable, and a stable frame structure is achieved.