Abstract: A computer-based method of reducing or limiting data transmissions from a computer to a remote network destination includes receiving an indication, at an agent on a computer, that a recent user activity has occurred at the computer. The indication typically includes data relevant to user context when the user activity occurred. The method further includes determining, with the agent, whether the data relevant to the user's context when the user activity occurred indicates that a change in user context relative to a user activity at the computer immediately prior to the recent user activity and conditioning a transmission of data relevant to the recent user activity from the computer to a remote network destination based on an outcome of the determination.

Abstract: The present invention provides methods for treating short bowel syndrome and/or high output ostomy. The invention comprises administering to a patient in need a long-acting GLP-1 receptor agonist. In various embodiments, the method reduces ostomy output, reduces requirement for parenteral nutrition, and/or ameliorates acute intestinal failure.

Abstract: A system for preventing duplication of a computer source file to a destination file includes a user application accessed by a user of a computer. An agent application hosted by the computer registers for a notification of a user interface action with an operating system (OS) of the computer. The agent receives notice from the OS of the user interface action and determines if the user interface action is indicative of a data file duplication operation of a source file to a destination file location The Agent compares a property of the source file and a property of the destination file location to a blocking criteria, and blocks the user interface action from reaching the application.

Abstract: A computer-based method includes: receiving an indication from a computer's operating system that a user has performed a first action that may have caused a context menu with a paste option to open on a screen of the computer, and subsequently receiving an indication from the computer's operating system that the user has performed a second action at the computer that may have amounted to a selection of the paste option on the context menu. In response to the indication from the computer's operating system that the user has performed the second action, the method includes determining if the second action by the user amounted to a selection of the paste option on the context menu and thereby cause a paste action to occur.

Abstract: Methods for treating fecal incontinence by administering to a subject in need thereof compositions including oxymetazoline as an active ingredient. Kits including compositions of oxymetazoline suitable for topical application, for the treatment of fecal incontinence.

Abstract: The present invention provides compositions comprising an effective amount of a peptide having the amino acid sequence Gly-Gly-(d)Val-(d)Leu-(d)Val-(d)Gln-(d)Pro-Gly (SEQ ID NO: 6) to promote tight junction integrity, or a pharmaceutically acceptable salt thereof, and a pharmaceutically-acceptable carrier. The present invention further provides methods of using the larazotide derivative compositions for promoting tight junction integrity in patients in need thereof.

Abstract: A computer-based method includes monitoring user activities at an endpoint device on a computer network, determining if one of the user activities at the endpoint device presents a potential threat to network security, creating an alert of the potential threat, and providing, with the alert, a redacted version of a screenshot from the endpoint device. One or more open windows that appeared on the screen of the endpoint device are obscured or removed in the redacted version of the screenshot of the endpoint device.

Abstract: A system for preventing duplication of a computer source file to a destination file includes a user application accessed by a user of a computer. An agent application hosted by the computer registers for a notification of a user interface action with an operating system (OS) of the computer. The agent receives notice from the OS of the user interface action and determines if the user interface action is indicative of a data file duplication operation of a source file to a destination file location The Agent compares a property of the source file and a property of the destination file location to a blocking criteria, and blocks the user interface action from reaching the application.

Abstract: A computer-based method of reducing or limiting data transmissions from a computer to a remote network destination includes receiving an indication, at an agent on a computer, that a recent user activity has occurred at the computer. The indication typically includes data relevant to user context when the user activity occurred. The method further includes determining, with the agent, whether the data relevant to the user's context when the user activity occurred indicates that a change in user context relative to a user activity at the computer immediately prior to the recent user activity and conditioning a transmission of data relevant to the recent user activity from the computer to a remote network destination based on an outcome of the determination.

Abstract: A computer-based method is disclosed to facilitate managing data exfiltration risk in a computer network environment. The method includes collecting computer file management information associated with each respective one of a plurality of computer files in an organization's computer network environment from a computer operating system, collecting user activity information associated with each respective one of a plurality of user sessions by users having access to the organization's computer network environment with a plurality of session monitoring agents, correlating at least some of the collected user activity information to one or more of the computer files associated with the collected file management information; and assessing data exfiltration risk with respect to one or more of the computer files based at least in part on some of the file management information and the correlated user activity information associated with a file history chain.

Abstract: The invention, in various aspects and embodiments, provides compositions and methods for treating or managing ulcerative colitis (UC) (including mild or moderate UC), including intestinal and extraintestinal symptoms, including but not limited to arthritis. The compositions and methods in various embodiments relate to oral administration of pharmaceutical compositions that comprise an effective amount of one or more agents that forms at least one 4-APAA compound by azo reduction in the colon. In various embodiments, active agent is available for local action in the lumen of the large intestine. Further, as described herein, a significant portion of the 4-APAA formed by azo reduction in the large intestine is systemically available to ameliorate extraintestinal symptoms.

Abstract: A computer-based method of reducing or limiting data transmissions from a computer to a remote network destination includes receiving an indication, at an agent on a computer, that a recent user activity has occurred at the computer. The indication typically includes data relevant to user context when the user activity occurred. The method further includes determining, with the agent, whether the data relevant to the user's context when the user activity occurred indicates that a change in user context relative to a user activity at the computer immediately prior to the recent user activity and conditioning a transmission of data relevant to the recent user activity from the computer to a remote network destination based on an outcome of the determination.

Abstract: A computer-based method of reducing or limiting data transmissions from a computer to a remote network destination includes receiving an indication, at an agent on a computer, that a recent user activity has occurred at the computer. The indication typically includes data relevant to user context when the user activity occurred. The method further includes determining, with the agent, whether the data relevant to the user's context when the user activity occurred indicates that a change in user context relative to a user activity at the computer immediately prior to the recent user activity and conditioning a transmission of data relevant to the recent user activity from the computer to a remote network destination based on an outcome of the determination.

Abstract: A system and method monitors access of an external storage device connected to a target device. A notification of a connection of the external storage device to the target device is received, a notification of an external file access on the external storage device is received, and activity of a user on the target device is monitored to detect a user operation accessing a source file stored on the target device. Events are logged based upon the connection, the user operation, and the external file access. Two or more of the events are associated with a copy of the source file to the external connected storage device and the source file history. An alert regarding the association is forwarded to a monitor application in communication with the target device.

Abstract: A computer-based method includes: receiving an indication from a computer's operating system that a user has performed a first action that may have caused a context menu with a paste option to open on a screen of the computer, and subsequently receiving an indication from the computer's operating system that the user has performed a second action at the computer that may have amounted to a selection of the paste option on the context menu. In response to the indication from the computer's operating system that the user has performed the second action, the method includes determining if the second action by the user amounted to a selection of the paste option on the context menu and thereby cause a paste action to occur.

Abstract: A system monitors access to a computer file via a dynamically changeable non¬ heterogeneous collection load balanced across two hash tables. User activity is monitored on a target device to detect a user entered pattern including a wildcard character. A server in communication with the target device, receives the user entered pattern, selects one of the two hash tables, and calculates an index for a pattern for the selected hash table based on the user entered pattern. The index is used to access the selected hash table to receive a stored pattern. The hash tables each have a plurality of entries, and each entry includes a list of one or more patterns that have the same hash index but different pattern values sorted by length in characters from longest to shortest.

Abstract: Methods for treating fecal incontinence by administering tc a subject in need thereof compositions including oxymetazoline as an active ingredient. Kits including compositions of oxymetazoline suitable for topical application, for the treatment of fecal incontinence.

Abstract: A device for drug delivery to an orifice of a subject, comprising a shell which is elastically stressed by an active pharmaceutical ingredient, said shell containing and being substantially impermeable to said active pharmaceutical ingredient, wherein said shell has at least one hole sized for in-vivo release of said active pharmaceutical ingredient as a result of elastic stressing.

Abstract: A computer-based method is disclosed to facilitate managing data exfiltration risk in a computer network environment. The method includes collecting computer file management information associated with each respective one of a plurality of computer files in an organization's computer network environment from a computer operating system, collecting user activity information associated with each respective one of a plurality of user sessions by users having access to the organization's computer network environment with a plurality of session monitoring agents, correlating at least some of the collected user activity information to one or more of the computer files associated with the collected file management information; and assessing data exfiltration risk with respect to one or more of the computer files based at least in part on some of the file management information and the correlated user activity information associated with a file history chain.

Abstract: The present invention provides a pharmaceutical composition comprising a selective serotonin reuptake inhibitor (SSRI) and a norepinephrine reuptake inhibitor (NRI), particularly, fluoxetine and reboxetine, for treating obesity. Surprisingly, the inventor of the present invention discovered that use of especially low doses of the active compounds, particularly, at most 6 mg/day of reboxetine and at most 20 mg/day of fluoxetine, wherein the reboxetinerfluoxetine ratio is from about 1:4 to about 1:6, induces an effective weight loss in obese patients. Advantageously, the combinations of the present invention include very low doses of the active ingredients, thereby decreasing possible drug-drug interactions and adverse drug reaction.