Patents by Inventor Nir Dotan

Nir Dotan has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • METHODS FOR PROGNOSIS OR TREATMENT OF PARKINSON'S DISEASE
    Publication number: 20200354791
    Abstract: Provided herein are methods for prognosing and treating a patient with Parkinson's disease (PD) or Parkinsonian symptoms. The prognosis and appropriate treatments can be determined by correlating the level of gene expression of SKP1a, UBE2K, ALDH1A1, PSMC4, HSPA8 and LAMB2 with a Parkinson's Disease rating scale, thereby prognosing slow or rapid progression of the symptoms or disease.
    Type: Application
    Filed: November 8, 2018
    Publication date: November 12, 2020
    Applicant: BIO SHAI LTD.
    Inventors: Jennifer YARDEN, Nir DOTAN, Danit MECHLOVICH, Jose Martin RABEY, Moussa B. H. YOUDIM
  • Method for diagnosing multiple sclerosis
    Patent number: 8216791
    Abstract: Disclosed is a method for diagnosing and prognosing multiple sclerosis and more particularly to a method for diagnosing and prognosing multiple sclerosis by measuring levels of antibodies. The levels of IgM-type anti-Glc(?1,2)Glc(?) or Glc(?1,3)Glc(?) or Glc(?1,6)Glc(?) antibodies in serum act as diagnostic markers for MS disease and as prognostic biomarkers for the conversion of CIS patients suggestive of MS to clinically definite MS (CDMS) within 24 months.
    Type: Grant
    Filed: September 9, 2009
    Date of Patent: July 10, 2012
    Assignee: Glycominds Ltd.
    Inventors: Nir Dotan, Avinoam Dukler
  • Immunoassay reagent compositions for diagnosing multiple sclerosis
    Patent number: 8129128
    Abstract: This application is related to immunoassay reagent compositions comprising a glycan reagent for diagnosing multiple sclerosis.
    Type: Grant
    Filed: August 5, 2009
    Date of Patent: March 6, 2012
    Assignee: Glycominds, Ltd.
    Inventors: Nir Dotan, Avinoam Dukler, Mikael Schwarz
  • Method for evaluating risk in multiple sclerosis
    Patent number: 8048639
    Abstract: The invention relates to methods and reagents for diagnosing and assessing the prognosis of multiple sclerosis.
    Type: Grant
    Filed: February 11, 2010
    Date of Patent: November 1, 2011
    Assignee: Glycominds Ltd.
    Inventors: Nir Dotan, Avinoam Dukler, Jennifer Yarden
  • COMPOSITION AND METHOD FOR PREDICTION OF COMPLICATED DISEASE COURSE IN CROHN'S DISEASE
    Publication number: 20110136255
    Abstract: Methods of identifying Crohn's disease patients who may require early surgery and/or who are susceptible to developing complications during the course of disease. Anti-laminarin (anti-L) and anti-chitin (anti-C) antibodies, both independently and combined, can serve as diagnostic and prognostic indices for Crohn's disease.
    Type: Application
    Filed: November 26, 2008
    Publication date: June 9, 2011
    Inventors: Nir Dotan, Avinoam Dukler
  • Method For Diagnosing Multiple Sclerosis
    Publication number: 20110092383
    Abstract: Disclosed is a method for diagnosing multiple sclerosis and more particularly to a method for diagnosing multiple sclerosis by measuring levels of antibodies to glycans in a biological sample.
    Type: Application
    Filed: October 14, 2010
    Publication date: April 21, 2011
    Applicant: Glycominds, LTD
    Inventors: Nir Dotan, Avinoam Dukler
  • Method for diagnosing multiple sclerosis
    Patent number: 7906291
    Abstract: Disclosed is a method for diagnosing multiple sclerosis and more particularly to a method for diagnosing multiple sclerosis by measuring levels of antibodies to glycans in a biological sample.
    Type: Grant
    Filed: January 31, 2006
    Date of Patent: March 15, 2011
    Assignee: Glycominds Ltd.
    Inventors: Nir Dotan, Avinoam Dukler
  • Method for Diagnosing Prognosing Inflammatory Bowel Disease and Crohn's Disease
    Publication number: 20100254971
    Abstract: Disclosed are methods for diagnosing and prognosing Inflammatory Bowel disease or Crohn's disease (CD) by measuring levels of antibodies to glycans in a biological sample.
    Type: Application
    Filed: October 26, 2009
    Publication date: October 7, 2010
    Applicant: Glycominds LTD.
    Inventors: Nir Dotan, Avinoam Dukler, Rom T. Altstock
  • Method for Evaluating Risk in Multiple Sclerosis
    Publication number: 20100227337
    Abstract: The invention relates to methods and reagents for diagnosing and assessing the prognosis of multiple sclerosis.
    Type: Application
    Filed: February 11, 2010
    Publication date: September 9, 2010
    Applicant: Glycominds LTD.
    Inventors: Nir Dotan, Avinoam Dukler, Jennifer Yarden
  • Method for Evaluating Risk in Multiple Sclerosis
    Publication number: 20100203569
    Abstract: The invention relates to methods and reagents for diagnosing and assessing the prognosis of multiple sclerosis. The present invention is based, in part, upon the discovery that anti-glycan antibodies are useful in evaluating the risk of whether clinically isolated syndrome (CIS) patients suggestive of Multiple sclerosis (MS) will have a clinical relapse within, e.g., 24 months. The invention is also based upon the discovery that anti-glycan antibodies are useful for evaluating the risk of CIS patients suggestive of MS to have a rapid disease progression and accumulate disabilities, e.g., permanent disability, within a certain time frame, e.g., 5 years.
    Type: Application
    Filed: September 9, 2009
    Publication date: August 12, 2010
    Applicant: Glycominks LTD
    Inventors: Nir Dotan, Avinoam Dukler
  • Method for Diagnosing Multiple Sclerosis
    Publication number: 20100159472
    Abstract: Disclosed is a method for diagnosing and prognosing multiple sclerosis and more particularly to a method for diagnosing and prognosing multiple sclerosis by measuring levels of antibodies. The levels of IgM-type anti-Glc(?1,2)Glc(?) or Glc(?1,3)Glc(?) or Glc(?1,6)Glc(?) antibodies in serum act as diagnostic markers for MS disease and as prognostic biomarkers for the conversion of CIS patients suggestive of MS to clinically definite MS (CDMS) within 24 months.
    Type: Application
    Filed: September 9, 2009
    Publication date: June 24, 2010
    Applicant: Glycominds, LTD
    Inventors: Nir Dotan, Avinoam Dukler
  • METHOD OF DIAGNOSING AND STRATIFYING ANTI-PHOSPHOLIPID SYNDROME
    Publication number: 20100105085
    Abstract: Disclosed are a method and reagents for diagnosis of anti phospholipid syndrome based on the levels of certain anti 1 can antibodies.
    Type: Application
    Filed: August 29, 2007
    Publication date: April 29, 2010
    Inventors: Nir Dotan, Avinoam Dukler
  • Method for Diagnosing Diseases Based on Levels of Anti-Glycan Antibodies
    Publication number: 20100099124
    Abstract: Disclosed are methods for diagnosing Crohn's disease (CD) or anti-phospholipid syndrome by measuring levels of antibodies to glycans in a biological sample.
    Type: Application
    Filed: September 21, 2009
    Publication date: April 22, 2010
    Applicant: Glycominds, LTD
    Inventors: Nir Dotan, Avinoam Dukler
  • Method for Diagnosing Multiple Sclerosis
    Publication number: 20100081160
    Abstract: Disclosed is a method for diagnosing multiple sclerosis and more particularly to a method for diagnosing multiple sclerosis by measuring levels of antibodies to glycans in a biological sample.
    Type: Application
    Filed: May 22, 2009
    Publication date: April 1, 2010
    Applicant: Glycominds LTD.
    Inventors: Nir Dotan, Avinoam Dukler, Mikael Schwarz, Ari Gargir
  • Method for Diagnosing Multiple Sclerosis
    Publication number: 20090291456
    Abstract: Disclosed is a method for diagnosing multiple sclerosis and more particularly to a method for diagnosing multiple sclerosis by measuring levels of antibodies to glycans in a biological sample.
    Type: Application
    Filed: August 5, 2009
    Publication date: November 26, 2009
    Applicant: Glycominds, LTD
    Inventors: Nir Dotan, Avinoam Dukler, Mikael Scwartz
  • Method for diagnosing and prognosing inflammatory bowel disease and crohn's disease
    Patent number: 7608414
    Abstract: Disclosed are methods for diagnosing and prognosing Inflammatory Bowel disease or Crohn's disease (CD) by measuring levels of antibodies to glycans in a biological sample.
    Type: Grant
    Filed: February 8, 2006
    Date of Patent: October 27, 2009
    Assignee: Glycominds, Ltd
    Inventors: Nir Dotan, Avinoam Dukler, Rom T. Altstock
  • Method for diagnosing diseases based on levels of anti-glycan antibodies
    Patent number: 7592150
    Abstract: Disclosed are methods for diagnosing Crohn's disease (CD) or anti-phospholipid syndrome by measuring levels of antibodies to glycans in a biological sample.
    Type: Grant
    Filed: December 3, 2003
    Date of Patent: September 22, 2009
    Assignee: Glycominds, Ltd
    Inventors: Nir Dotan, Avinoam Dukler
  • Method for diagnosing multiple sclerosis
    Patent number: 7572592
    Abstract: Disclosed is a method for diagnosing multiple sclerosis and more particularly to a method for diagnosing multiple sclerosis by measuring levels of antibodies to glycans in a biological sample.
    Type: Grant
    Filed: January 31, 2005
    Date of Patent: August 11, 2009
    Assignee: Glycominds Ltd
    Inventors: Nir Dotan, Avinoam Dukler, Mikael Scwartz
  • Method for diagnosing multiple sclerosis
    Patent number: 7537900
    Abstract: Disclosed is a method for diagnosing multiple sclerosis and more particularly to a method for diagnosing multiple sclerosis by measuring levels of antibodies to glycans in a biological sample.
    Type: Grant
    Filed: August 4, 2003
    Date of Patent: May 26, 2009
    Assignee: Glycominds Ltd.
    Inventors: Nir Dotan, Avinoam Dukler, Mikael Schwarz, Ari Gargir
  • Combinatorial complex carbohydrate libraries and methods for the manufacture and uses thereof
    Publication number: 20080085838
    Abstract: A combinatorial complex carbohydrate library is provided and including a plurality of addressable complex carbohydrate structures.
    Type: Application
    Filed: September 5, 2007
    Publication date: April 10, 2008
    Applicant: Glycominds Ltd.
    Inventors: Avinoam Dukler, Nir Dotan