Abstract: In aspects, the invention provides a method of treating or preventing a nidovirus or picornavirus infection in a subject, the method comprising administering to a subject in need thereof an effective amount of an active agent of butamben, butylparaben, conivaptan, amphotericin B, pentoxyverine, lapatinib, vilazodone, imatinib (STI571), benztropine, raloxifene, solifenacin, retapamulin, bafetinib (INNO-406), imipramine, trimipramine, tolterodine, clomipramine, velpatasvir, cediranib (AZD2171), azelastine, desloratadine, nortriptyline, propafenone, mebeverine, elbasvir, cepharanthine, flupenthixol dihydrochloride, or a pharmaceutically acceptable salt thereof.

Abstract: A method for the treatment of a coronavirus infection, such as a SARS-CoV-2 infection causing coronavirus disease 2019 (COVID-19), in a subject in need thereof, which includes the administration of masitinib, or a pharmaceutically acceptable salt or solvate thereof. In addition, at least one further pharmaceutically active agent may also be administered.