Patents by Inventor Nir Kossovsky
Nir Kossovsky has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Publication number: 20020004775Abstract: An online patent and license exchange is provided which enables potential licensors and licensees of patents and other intellectual property rights to efficiently and reliably transact IP license or assignment agreements. Three markets are part of the exchange: a license market, an option market and a securitized asset Securitized Asset cash flows market. The online patent and license exchange includes a method of providing a valuation of an IP asset using data from companies in a similar technology classification as the IP asset, a method of generating a suggested IP asset asking price, an index of IP market value according to technology classification, a method for quantifying the financial risk of an asset (&bgr;), and a quantitative database of technology attributes of IP assets.Type: ApplicationFiled: April 20, 2001Publication date: January 10, 2002Inventors: Nir Kossovsky, Bear Brandegee, Alexander K. Arrow
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Publication number: 20020002524Abstract: An online patent and license exchange is provided which enables potential licensors and licensees of patents and other intellectual property rights to efficiently and reliably transact IP license or assignment agreements. The online patent and license exchange includes a method of providing a valuation of an IP asset using data from companies in a similar technology classification as the IP asset, a method of generating a suggested IP asset asking price, an index of IP market value according to technology classification, a method for quantifying the financial risk of an asset (&bgr;), and a quantitative database of technology attributes of IP assets. The valuation is also used in valuing IP assets to provide insurance for sale transactions, in securitization, collateralization, and donation for tax purposes of IP assets, and in prioritization of assets in an IP portfolio.Type: ApplicationFiled: April 20, 2001Publication date: January 3, 2002Inventors: Nir Kossovsky, Bear Brandegee, Alexander K. Arrow
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Publication number: 20020002523Abstract: An online patent and license exchange is provided which enables potential licensors and licensees of patents and other intellectual property rights to efficiently and reliably transact IP license or assignment agreements. The online patent and license exchange includes a method of providing a valuation of an IP asset using data from companies in a similar technology classification as the IP asset, a method of generating a suggested IP asset asking price, an index of IP market value according to technology classification, a method for quantifying the financial risk of an asset (&bgr;), and a quantitative database of technology attributes of IP assets. The valuation is also used in valuing IP assets to provide insurance for sale transactions, in securitization, collateralization, and donation for tax purposes of IP assets, and in prioritization of assets in an IP portfolio.Type: ApplicationFiled: April 20, 2001Publication date: January 3, 2002Inventors: Nir Kossovsky, Bear Brandegee, Alexander K. Arrow
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Patent number: 5798220Abstract: A method for detecting immunogenic responses to native macromolecules. The native macromolecule is bound to a biomaterial or pharmacologic support surface and used in an immunoassay to screen biological fluids for antibodies to the macromolecule in its bound state. The method is used to screen for immune responses to implanted biomaterials and pharmacologically administered agents where native macromolecules which have interacted with the implant are conformationally altered and elicit an immune response.Type: GrantFiled: May 25, 1995Date of Patent: August 25, 1998Assignee: The Regents of the University of CaliforniaInventor: Nir Kossovsky
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Patent number: 5639505Abstract: Articles of manufacture which are adapted for use in contact with one or more biologically active agents are coated with a glassy carbohydrate film. The glassy film provides a reduced surface energy coating which exhibits a reduced degree of binding with biologically active agents. Methods for applying the glassy carbohydrate film are disclosed wherein the glassy film is adsorbed directly onto the article surface.The coated articles are for use both in vitro and in vivo where contact with biologically active agents is expected.Type: GrantFiled: May 23, 1995Date of Patent: June 17, 1997Assignee: The Regents of the University of CaliforniaInventors: Nir Kossovsky, Andrew E. Gelman, Edward E. Sponsler
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Patent number: 5585646Abstract: Improved bio-electronic devices in which a layer of a polyhydroxy oligomer is provided between the surface of a semiconductor material and an electronically active biochemical molecule which is designed to be bound to the semiconductor surface to provide an electronic device. The layer of polyhydroxy oligomer functions as a biochemical stabilization layer to prevent denaturization of the electronically active biochemical molecule.Type: GrantFiled: May 23, 1995Date of Patent: December 17, 1996Assignee: The Regents of the University of CaliforniaInventors: Nir Kossovsky, Andrew Gelman, H. James Hnatyszyn, Samir Rajguru
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Patent number: 5506420Abstract: Improved bio-electronic devices in which a layer of a polyhydroxy oligomer is provided between the surface of a semiconductor material and an electronically active biochemical molecule which is designed to be bound to the semiconductor surface to provide an electronic device. The layer of polyhydroxy oligomer functions as a biochemical stabilization layer to prevent denaturization of the electronically active biochemical molecule.Type: GrantFiled: September 14, 1994Date of Patent: April 9, 1996Assignee: The Regents of the University of CaliforniaInventors: Nir Kossovsky, Andrew Gelman, H. James Hnatyszyn, Samir Rajguru
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Patent number: 5464634Abstract: A red blood cell surrogate which is composed of a nanocrystalline core particle to which an oxygen carrier such as hemoglobin is bound. An oxygen carrier anchor coating is provided between the nanocrystalline core particle and the oxygen carrier in order to provide binding of the oxygen carrier to the nanocrystalline core particle without denaturing the oxygen carrier or otherwise destroying its oxygen carrying capacity. The nanocrystalline core particle with the oxygen carrier bound thereto is coated with a layer of lipid and then an outer layer of a sugar or allosteric effector is applied.Type: GrantFiled: April 25, 1994Date of Patent: November 7, 1995Assignee: The Regents of the University of CaliforniaInventors: Nir Kossovsky, Andrew E. Gelman, H. James Hnatyszyn
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Patent number: 5462751Abstract: A biologically active composition made up of biodegradable core particles which are coated with a layer that is designed to allow attachment of biologically active agents without denaturing them. The composition may further include an exterior targeting membrane which provides selective targeting to specific receptors.Type: GrantFiled: November 1, 1993Date of Patent: October 31, 1995Assignee: The Regeants of the University of CaliforniaInventors: Nir Kossovsky, H. James Hnatyszyn, Andrew Gelman
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Patent number: 5462750Abstract: A biologically active composition made up of core particles having diameters of less than about 1000 nanometers which are coated with a layer which is designed to allow attachment of biologically active proteins, peptides or pharmacological agents to the microparticles. When viral protein is attached to the core particles, the result is a viral decoy which accurately mimics the native virus in both size and structure while being entirely devoid of virulent activity due to the microparticle core. Other antigenic proteins or peptides are attached to provide molecules which are useful in raising antibodies or as a diagnostic tool. Further, pharmacological agents are attached to the microparticles to provide pharmaceutical compositions.Type: GrantFiled: April 8, 1994Date of Patent: October 31, 1995Assignee: The Regents of the University of CaliforniaInventors: Nir Kossovsky, Rointan F. Bunshah
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Patent number: 5460831Abstract: A biologically active composition for use in gene therapy and other transfection procedures. The composition is composed of nanocrystalline core particles which are coated with a layer that is designed to allow attachment of transfection agents (DNA/RNA segments or antisense fragments) without denaturing them. The composition may further include an exterior targeting membrane which provides selective targeting of the transfection agents to specific cell receptors.Type: GrantFiled: November 4, 1993Date of Patent: October 24, 1995Assignee: The Regents of the University of CaliforniaInventors: Nir Kossovsky, H. James Hnatyszyn, Andrew Gelman
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Patent number: 5460830Abstract: A biologically active composition made up of core particles or surfaces which are coated with a layer which is designed to allow attachment of biochemically reactive pairs (BRP's) without denaturing the BRP to the microparticles. BRP's which may be attached include ligand-receptor pairs, enzyme-substrate pairs, drug-receptor pairs, catalyst-reactant pairs, toxin-ligand pairs, absorbant-absorbate pairs and adsorbant-adsorbate pairs.Type: GrantFiled: November 1, 1993Date of Patent: October 24, 1995Assignee: The Regents of the University of CaliforniaInventors: Nir Kossovsky, Edward Sponsler, Andrew Gelman, Samir Rajguru
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Patent number: 5441739Abstract: Articles of manufacture which are adapted for use in contact with one or more biologically active agents are coated with a glassy carbohydrate film. The glassy film provides a reduced surface energy coating which exhibits a reduced degree of binding with biologically active agents. Methods for applying the glassy carbohydrate film are disclosed wherein the glassy film is adsorbed directly onto the article surface. The coated articles are for use both in vitro and in vivo where contact with biologically active agents is expected.Type: GrantFiled: March 11, 1993Date of Patent: August 15, 1995Assignee: The Regents of the University of CaliforniaInventors: Nir Kossovsky, Andrew E. Gelman, Edward E. Sponsler
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Patent number: 5334394Abstract: A biologically active composition made up of core particles having diameters of less than about 1000 nanometers which are coated with a layer which is designed to allow attachment of biologically active proteins, peptides or pharmacological agents to the microparticles. When Human Immunodeficiency Virus (HIV) viral protein is attached to the core particles, the result is a viral decoy which accurately mimics native HIV in size, structure and surface character while being entirely devoid of virulent activity due to the microparticle core. The HIV decoy is useful as a vaccine for treating mammals to elicit an immune response.Type: GrantFiled: January 4, 1993Date of Patent: August 2, 1994Assignee: The Regents of the University of CaliforniaInventors: Nir Kossovsky, Andrew E. Gelman, Edward E. Sponsler
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Patent number: 5306508Abstract: A red blood cell surrogate which is composed of a nanocrystalline core particle to which an oxygen carrier such as hemoglobin is bound. An oxygen carrier anchor coating is provided between the nanocrystalline core particle and the oxygen carrier in order to provide binding of the oxygen carrier to the nanocrystalline core particle without denaturing the oxygen carrier or otherwise destroying its oxygen carrying capacity. The nanocrystalline core particle with the oxygen carrier bound thereto is coated with an exterior layer of lipid.Type: GrantFiled: March 11, 1993Date of Patent: April 26, 1994Assignee: The Regents of the University of CaliforniaInventors: Nir Kossovsky, Andrew E. Gelman, Edward E. Sponsler
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Patent number: 5219577Abstract: A biologically active composition made up of core particles having diameters of less than about 1000 nanometers which are coated with a layer which is designed to allow attachment of biologically active proteins, peptides or pharmacological agents to the microparticles. When viral protein is attached to the core particles, the result is a viral decoy which accurately mimics the native virus in both size and structure while being entirely devoid of virulent activity due to the microparticle core. Other antigenic proteins or peptides are attached to provide molecules which are useful in raising antibodies or as a diagnostic tool. Further, pharmacological agents are attached to the microparticles to provide pharmaceutical compositions.Type: GrantFiled: June 22, 1990Date of Patent: June 15, 1993Assignee: The Regents of the University of CaliforniaInventors: Nir Kossovsky, Rointan F. Bunshah
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Patent number: 5178882Abstract: A biologically active composition made up of core particles having diameters of less than about 1000 nanometers which are coated with a layer which is designed to allow attachment of biologically active proteins, peptides or pharmacological agents to the microparticles. When viral protein is attached to the core particles, the result is a viral decoy which accurately mimics the native virus in both size and structure while being entirely devoid of virulent activity due to the microparticle core. Other antigenic proteins or peptides are attached to provide molecules which are useful in raising antibodies or as a diagnostic tool. Further, pharmacological agents are attached to the microparticles to provide pharmaceutical compositions. The viral decoys are useful as vaccines for treating animals to elicit an immune response.Type: GrantFiled: April 24, 1991Date of Patent: January 12, 1993Assignee: The Regents of the University of CaliforniaInventors: Nir Kossovsky, Rointan F. Bunshah