Patents by Inventor Nir Kossovsky

Nir Kossovsky has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Publication number: 20020004775
    Abstract: An online patent and license exchange is provided which enables potential licensors and licensees of patents and other intellectual property rights to efficiently and reliably transact IP license or assignment agreements. Three markets are part of the exchange: a license market, an option market and a securitized asset Securitized Asset cash flows market. The online patent and license exchange includes a method of providing a valuation of an IP asset using data from companies in a similar technology classification as the IP asset, a method of generating a suggested IP asset asking price, an index of IP market value according to technology classification, a method for quantifying the financial risk of an asset (&bgr;), and a quantitative database of technology attributes of IP assets.
    Type: Application
    Filed: April 20, 2001
    Publication date: January 10, 2002
    Inventors: Nir Kossovsky, Bear Brandegee, Alexander K. Arrow
  • Publication number: 20020002524
    Abstract: An online patent and license exchange is provided which enables potential licensors and licensees of patents and other intellectual property rights to efficiently and reliably transact IP license or assignment agreements. The online patent and license exchange includes a method of providing a valuation of an IP asset using data from companies in a similar technology classification as the IP asset, a method of generating a suggested IP asset asking price, an index of IP market value according to technology classification, a method for quantifying the financial risk of an asset (&bgr;), and a quantitative database of technology attributes of IP assets. The valuation is also used in valuing IP assets to provide insurance for sale transactions, in securitization, collateralization, and donation for tax purposes of IP assets, and in prioritization of assets in an IP portfolio.
    Type: Application
    Filed: April 20, 2001
    Publication date: January 3, 2002
    Inventors: Nir Kossovsky, Bear Brandegee, Alexander K. Arrow
  • Publication number: 20020002523
    Abstract: An online patent and license exchange is provided which enables potential licensors and licensees of patents and other intellectual property rights to efficiently and reliably transact IP license or assignment agreements. The online patent and license exchange includes a method of providing a valuation of an IP asset using data from companies in a similar technology classification as the IP asset, a method of generating a suggested IP asset asking price, an index of IP market value according to technology classification, a method for quantifying the financial risk of an asset (&bgr;), and a quantitative database of technology attributes of IP assets. The valuation is also used in valuing IP assets to provide insurance for sale transactions, in securitization, collateralization, and donation for tax purposes of IP assets, and in prioritization of assets in an IP portfolio.
    Type: Application
    Filed: April 20, 2001
    Publication date: January 3, 2002
    Inventors: Nir Kossovsky, Bear Brandegee, Alexander K. Arrow
  • Patent number: 5798220
    Abstract: A method for detecting immunogenic responses to native macromolecules. The native macromolecule is bound to a biomaterial or pharmacologic support surface and used in an immunoassay to screen biological fluids for antibodies to the macromolecule in its bound state. The method is used to screen for immune responses to implanted biomaterials and pharmacologically administered agents where native macromolecules which have interacted with the implant are conformationally altered and elicit an immune response.
    Type: Grant
    Filed: May 25, 1995
    Date of Patent: August 25, 1998
    Assignee: The Regents of the University of California
    Inventor: Nir Kossovsky
  • Patent number: 5639505
    Abstract: Articles of manufacture which are adapted for use in contact with one or more biologically active agents are coated with a glassy carbohydrate film. The glassy film provides a reduced surface energy coating which exhibits a reduced degree of binding with biologically active agents. Methods for applying the glassy carbohydrate film are disclosed wherein the glassy film is adsorbed directly onto the article surface.The coated articles are for use both in vitro and in vivo where contact with biologically active agents is expected.
    Type: Grant
    Filed: May 23, 1995
    Date of Patent: June 17, 1997
    Assignee: The Regents of the University of California
    Inventors: Nir Kossovsky, Andrew E. Gelman, Edward E. Sponsler
  • Patent number: 5585646
    Abstract: Improved bio-electronic devices in which a layer of a polyhydroxy oligomer is provided between the surface of a semiconductor material and an electronically active biochemical molecule which is designed to be bound to the semiconductor surface to provide an electronic device. The layer of polyhydroxy oligomer functions as a biochemical stabilization layer to prevent denaturization of the electronically active biochemical molecule.
    Type: Grant
    Filed: May 23, 1995
    Date of Patent: December 17, 1996
    Assignee: The Regents of the University of California
    Inventors: Nir Kossovsky, Andrew Gelman, H. James Hnatyszyn, Samir Rajguru
  • Patent number: 5506420
    Abstract: Improved bio-electronic devices in which a layer of a polyhydroxy oligomer is provided between the surface of a semiconductor material and an electronically active biochemical molecule which is designed to be bound to the semiconductor surface to provide an electronic device. The layer of polyhydroxy oligomer functions as a biochemical stabilization layer to prevent denaturization of the electronically active biochemical molecule.
    Type: Grant
    Filed: September 14, 1994
    Date of Patent: April 9, 1996
    Assignee: The Regents of the University of California
    Inventors: Nir Kossovsky, Andrew Gelman, H. James Hnatyszyn, Samir Rajguru
  • Patent number: 5464634
    Abstract: A red blood cell surrogate which is composed of a nanocrystalline core particle to which an oxygen carrier such as hemoglobin is bound. An oxygen carrier anchor coating is provided between the nanocrystalline core particle and the oxygen carrier in order to provide binding of the oxygen carrier to the nanocrystalline core particle without denaturing the oxygen carrier or otherwise destroying its oxygen carrying capacity. The nanocrystalline core particle with the oxygen carrier bound thereto is coated with a layer of lipid and then an outer layer of a sugar or allosteric effector is applied.
    Type: Grant
    Filed: April 25, 1994
    Date of Patent: November 7, 1995
    Assignee: The Regents of the University of California
    Inventors: Nir Kossovsky, Andrew E. Gelman, H. James Hnatyszyn
  • Patent number: 5462750
    Abstract: A biologically active composition made up of core particles having diameters of less than about 1000 nanometers which are coated with a layer which is designed to allow attachment of biologically active proteins, peptides or pharmacological agents to the microparticles. When viral protein is attached to the core particles, the result is a viral decoy which accurately mimics the native virus in both size and structure while being entirely devoid of virulent activity due to the microparticle core. Other antigenic proteins or peptides are attached to provide molecules which are useful in raising antibodies or as a diagnostic tool. Further, pharmacological agents are attached to the microparticles to provide pharmaceutical compositions.
    Type: Grant
    Filed: April 8, 1994
    Date of Patent: October 31, 1995
    Assignee: The Regents of the University of California
    Inventors: Nir Kossovsky, Rointan F. Bunshah
  • Patent number: 5462751
    Abstract: A biologically active composition made up of biodegradable core particles which are coated with a layer that is designed to allow attachment of biologically active agents without denaturing them. The composition may further include an exterior targeting membrane which provides selective targeting to specific receptors.
    Type: Grant
    Filed: November 1, 1993
    Date of Patent: October 31, 1995
    Assignee: The Regeants of the University of California
    Inventors: Nir Kossovsky, H. James Hnatyszyn, Andrew Gelman
  • Patent number: 5460831
    Abstract: A biologically active composition for use in gene therapy and other transfection procedures. The composition is composed of nanocrystalline core particles which are coated with a layer that is designed to allow attachment of transfection agents (DNA/RNA segments or antisense fragments) without denaturing them. The composition may further include an exterior targeting membrane which provides selective targeting of the transfection agents to specific cell receptors.
    Type: Grant
    Filed: November 4, 1993
    Date of Patent: October 24, 1995
    Assignee: The Regents of the University of California
    Inventors: Nir Kossovsky, H. James Hnatyszyn, Andrew Gelman
  • Patent number: 5460830
    Abstract: A biologically active composition made up of core particles or surfaces which are coated with a layer which is designed to allow attachment of biochemically reactive pairs (BRP's) without denaturing the BRP to the microparticles. BRP's which may be attached include ligand-receptor pairs, enzyme-substrate pairs, drug-receptor pairs, catalyst-reactant pairs, toxin-ligand pairs, absorbant-absorbate pairs and adsorbant-adsorbate pairs.
    Type: Grant
    Filed: November 1, 1993
    Date of Patent: October 24, 1995
    Assignee: The Regents of the University of California
    Inventors: Nir Kossovsky, Edward Sponsler, Andrew Gelman, Samir Rajguru
  • Patent number: 5441739
    Abstract: Articles of manufacture which are adapted for use in contact with one or more biologically active agents are coated with a glassy carbohydrate film. The glassy film provides a reduced surface energy coating which exhibits a reduced degree of binding with biologically active agents. Methods for applying the glassy carbohydrate film are disclosed wherein the glassy film is adsorbed directly onto the article surface. The coated articles are for use both in vitro and in vivo where contact with biologically active agents is expected.
    Type: Grant
    Filed: March 11, 1993
    Date of Patent: August 15, 1995
    Assignee: The Regents of the University of California
    Inventors: Nir Kossovsky, Andrew E. Gelman, Edward E. Sponsler
  • Patent number: 5334394
    Abstract: A biologically active composition made up of core particles having diameters of less than about 1000 nanometers which are coated with a layer which is designed to allow attachment of biologically active proteins, peptides or pharmacological agents to the microparticles. When Human Immunodeficiency Virus (HIV) viral protein is attached to the core particles, the result is a viral decoy which accurately mimics native HIV in size, structure and surface character while being entirely devoid of virulent activity due to the microparticle core. The HIV decoy is useful as a vaccine for treating mammals to elicit an immune response.
    Type: Grant
    Filed: January 4, 1993
    Date of Patent: August 2, 1994
    Assignee: The Regents of the University of California
    Inventors: Nir Kossovsky, Andrew E. Gelman, Edward E. Sponsler
  • Patent number: 5306508
    Abstract: A red blood cell surrogate which is composed of a nanocrystalline core particle to which an oxygen carrier such as hemoglobin is bound. An oxygen carrier anchor coating is provided between the nanocrystalline core particle and the oxygen carrier in order to provide binding of the oxygen carrier to the nanocrystalline core particle without denaturing the oxygen carrier or otherwise destroying its oxygen carrying capacity. The nanocrystalline core particle with the oxygen carrier bound thereto is coated with an exterior layer of lipid.
    Type: Grant
    Filed: March 11, 1993
    Date of Patent: April 26, 1994
    Assignee: The Regents of the University of California
    Inventors: Nir Kossovsky, Andrew E. Gelman, Edward E. Sponsler
  • Patent number: 5219577
    Abstract: A biologically active composition made up of core particles having diameters of less than about 1000 nanometers which are coated with a layer which is designed to allow attachment of biologically active proteins, peptides or pharmacological agents to the microparticles. When viral protein is attached to the core particles, the result is a viral decoy which accurately mimics the native virus in both size and structure while being entirely devoid of virulent activity due to the microparticle core. Other antigenic proteins or peptides are attached to provide molecules which are useful in raising antibodies or as a diagnostic tool. Further, pharmacological agents are attached to the microparticles to provide pharmaceutical compositions.
    Type: Grant
    Filed: June 22, 1990
    Date of Patent: June 15, 1993
    Assignee: The Regents of the University of California
    Inventors: Nir Kossovsky, Rointan F. Bunshah
  • Patent number: 5178882
    Abstract: A biologically active composition made up of core particles having diameters of less than about 1000 nanometers which are coated with a layer which is designed to allow attachment of biologically active proteins, peptides or pharmacological agents to the microparticles. When viral protein is attached to the core particles, the result is a viral decoy which accurately mimics the native virus in both size and structure while being entirely devoid of virulent activity due to the microparticle core. Other antigenic proteins or peptides are attached to provide molecules which are useful in raising antibodies or as a diagnostic tool. Further, pharmacological agents are attached to the microparticles to provide pharmaceutical compositions. The viral decoys are useful as vaccines for treating animals to elicit an immune response.
    Type: Grant
    Filed: April 24, 1991
    Date of Patent: January 12, 1993
    Assignee: The Regents of the University of California
    Inventors: Nir Kossovsky, Rointan F. Bunshah