Abstract: There is provided a method for matching subject data to database patient data based on matching phenotypes and related genetic sequences, comprising: receiving a dataset including at least one phenotype disease description of a subject and a genetic sequence of the subject, the phenotype disease description describing clinically significant manifestations of disease in the subject; calculating a ranking score for each of a dataset of patients, the ranking score indicative of a similarity correlation between the dataset of each respective patient and the dataset of the subject, wherein the related genetic sequences of the dataset of patients are underlying genetic mutations attributable to the at least one phenotypic disease description; matching the dataset of the subject with at least one dataset of patients according to a requirement of the ranking score; and providing data indicative of the matched patients.