Patents by Inventor Niraj Shrestha

Niraj Shrestha has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • METHODS OF REDUCING NEUROINFLAMMATION
    Publication number: 20260174833
    Abstract: Provided herein are multi-chain chimeric polypeptides and use thereof in reducing neuroinflammation in a subject.
    Type: Application
    Filed: February 26, 2026
    Publication date: June 25, 2026
    Inventors: Hing C. Wong, Varghese George, Niraj Shrestha, Pallavi Chaturvedi
  • METHODS OF MODULATING CIRCADIAN CLOCK GENE EXPRESSION
    Publication number: 20260137759
    Abstract: Provided herein are multi-chain chimeric polypeptides and use thereof in modulating circadian clock gene expression in a subject.
    Type: Application
    Filed: April 13, 2023
    Publication date: May 21, 2026
    Inventors: Hing C. WONG, Christopher JANNEY, Varghese GEORGE, Niraj SHRESTHA, Pallavi CHATURVEDI
  • MULTI-CHAIN CHIMERIC POLYPEPTIDES AND USE THEREOF IN THE TREATMENT OF LIVER DISEASES
    Publication number: 20260131018
    Abstract: Provided herein are multi-chain chimeric polypeptides and use thereof in the treatment of liver diseases.
    Type: Application
    Filed: December 19, 2025
    Publication date: May 14, 2026
    Inventors: Hing C. Wong, Xiaoyun Zhu, Pallavi Chaturvedi, Varghese George, Niraj Shrestha, Michael Dee
  • Methods of reducing neuroinflammation
    Patent number: 12594323
    Abstract: Provided herein are multi-chain chimeric polypeptides and use thereof in reducing neuroinflammation in a subject.
    Type: Grant
    Filed: April 13, 2023
    Date of Patent: April 7, 2026
    Assignee: ImmunityBio, Inc.
    Inventors: Hing C. Wong, Varghese George, Niraj Shrestha, Pallavi Chaturvedi
  • METHODS OF TREATING BRONCHOPULMONARY DYSPLASIA
    Publication number: 20250352618
    Abstract: Provided herein are multi-chain chimeric polypeptides and use thereof in treating bronchopulmonary dysplasia in a subject.
    Type: Application
    Filed: May 20, 2025
    Publication date: November 20, 2025
    Inventors: Hing C. Wong, Niraj Shrestha, Mark Leonard Ormiston, Declan Joseph Gainer
  • Methods of activating regulatory T cells
    Patent number: 12398189
    Abstract: Provided herein are methods of stimulating or increasing the proliferation of a Treg cell, compositions including a population of Treg cells generated by these methods, and methods of treating a subject using these compositions.
    Type: Grant
    Filed: February 11, 2021
    Date of Patent: August 26, 2025
    Assignee: HCW Biologics, Inc.
    Inventors: Hing C. Wong, Niraj Shrestha, Varghese George, Michael Dee
  • METHODS OF GENERATING, STIMULATING, OR INCREASING PROLIFERATION OF DIFFERENT SUBSETS OF CD8+ T CELLS
    Publication number: 20250108112
    Abstract: Provided herein are multi-chain chimeric polypeptides and use thereof in generating, and/or stimulating, and/or increasing proliferation of different subsets of CD8+ T cells. Further, provided herein are pharmaceutical compositions comprising the multi-chain chimeric polypeptides. In addition, kits comprising the pharmaceutical compositions comprising the multi-chain chimeric polypeptides disclosed herein are also provided.
    Type: Application
    Filed: October 2, 2024
    Publication date: April 3, 2025
    Inventors: Hing C. Wong, Bai Liu, Niraj Shrestha
  • METHODS OF REDUCING NEUROINFLAMMATION
    Publication number: 20230372444
    Abstract: Provided herein are multi-chain chimeric polypeptides and use thereof in reducing neuroinflammation in a subject.
    Type: Application
    Filed: April 13, 2023
    Publication date: November 23, 2023
    Inventors: Hing C. Wong, Varghese George, Niraj Shrestha, Pallavi Chaturvedi
  • MULTI-CHAIN CHIMERIC POLYPEPTIDES AND USE THEREOF IN THE TREATMENT OF LIVER DISEASES
    Publication number: 20230125173
    Abstract: Provided herein are multi-chain chimeric polypeptides and use thereof in the treatment of liver diseases.
    Type: Application
    Filed: August 11, 2022
    Publication date: April 27, 2023
    Applicant: HCW Biologics, Inc.
    Inventors: Hing C. Wong, Xiaoyun Zhu, Pallavi Chaturvedi, Varghese George, Niraj Shrestha, Michael Dee
  • ALT-803 IN COMBINATION WITH ANTI-CD38 ANTIBODY FOR CANCER THERAPIES
    Publication number: 20190048055
    Abstract: The invention features combination therapies using an IL-15-based superagonist complex and an antibody to effectively treat subjects with cancer and infectious diseases.
    Type: Application
    Filed: March 27, 2018
    Publication date: February 14, 2019
    Inventors: Niraj Shrestha, Bai Liu, Peter Rhode, Hing C. Wong