Abstract: Among the various aspects of the present disclosure is the provision of bifunctional inhibitors of tetracycline inactivating enzymes and methods of use thereof. Herein, compositions for inhibitors of tetracycline inactivating enzymes are described. Additionally, a method of treatment for multidrug resistant bacterial infections using inhibitors of tetracycline inactivating enzymes is disclosed.

Abstract: Compositions for overcoming tetracycline antibiotic resistance and methods of use thereof are provided. Compositions include at least one compound selected from Formula (I) and Formula (II) as disclosed herein. Methods of treating a subject having a bacterial infection include administering at least one compound selected from Formula (I) and Formula (II) as disclosed herein. In some embodiments, the composition further includes at least one tetracycline antibiotic.

Abstract: The present disclosure provides immunogenic compositions and methods for vaccination with a CelTOS immunogen. The immunogenic composition comprises Babesia, Theileria or Cytauxzoon CelTOS. The immunogenic composition may also comprise CelTOS with structural changes that affect immune recognition.

Abstract: Disclosed herein are system, method, and computer program product embodiments for transforming backups of applications. An embodiment operates by extracting a resource snapshot into memory. The resource snapshot is formatted in a first configuration. An embodiment performs a transformation on the resource snapshot, thereby transforming the resource snapshot from the first configuration to a second configuration for an environment into which the resource snapshot is being restored. The transformation is made up of a set of operations. One of the operations includes a regular expression. Once the transformation is complete, the resource snapshot is restored to the environment based on the second configuration.

Abstract: Disclosed herein are system, method, and computer program product embodiments for transforming backups of applications. An embodiment operates by extracting a resource snapshot into memory. The resource snapshot is formatted in a first configuration. An embodiment performs a transformation on the resource snapshot, thereby transforming the resource snapshot from the first configuration to a second configuration for an environment into which the resource snapshot is being restored. The transformation is made up of a set of operations. One of the operations includes a regular expression. Once the transformation is complete, the resource snapshot is restored to the environment based on the second configuration.

Abstract: Embodiments described herein are directed to backing up and recovering cloud-native applications. In some embodiments, the data engine maps a first set of data volumes to a data repository dedicated to store a backup of the data associated with the application. Furthermore, the data engine transmits, using a dynamically generated process, the data stored in the identified first set of data volumes to the data repository for backup based on the mapping. The data engine may also initiate a recovery of the application. The data engine may use a new dynamically generated process to identify and transmit a respective data set to a corresponding data volume for storage. Moreover, the data engine may use the new process to restore the components of the application using each respective identified data set.

Abstract: Disclosed herein are system, method, and computer program product embodiments for transforming backups of applications. An embodiment operates by extracting a resource snapshot into memory. The resource snapshot is formatted in a first configuration. An embodiment performs a transformation on the resource snapshot, thereby transforming the resource snapshot from the first configuration to a second configuration for an environment into which the resource snapshot is being restored. The transformation is made up of a set of operations. One of the operations includes a regular expression. Once the transformation is complete, the resource snapshot is restored to the environment based on the second configuration.

Abstract: Embodiments described herein are directed to backing up and recovering cloud-native applications. In some embodiments, the data engine maps a first set of data volumes to a data repository dedicated to store a backup of the data associated with the application. Furthermore, the data engine transmits, using a dynamically generated process, the data stored in the identified first set of data volumes to the data repository for backup based on the mapping. The data engine may also initiate a recovery of the application. The data engine may use a new dynamically generated process to identify and transmit a respective data set to a corresponding data volume for storage. Moreover, the data engine may use the new process to restore the components of the application using each respective identified data set.

Abstract: Compounding file system metadata operations via buffering is disclosed. In various embodiments, an indication to send locally-stored file system operations to a remote file system metadata server is received. A dependency graph or other data structure reflecting dependencies between the locally-stored file system operations to identify a linear chain of dependent file system operations. Operations comprising the linear chain are combined into a compound file system operation. The compound file system operation is sent to the remote file system metadata server.

Abstract: A method, article of manufacture, and apparatus for limited deduplication scope on a distributed file system is discussed. A write request is received from a client at the metadata server (“MDS”), where the write request comprises a data object identifier and a preferred object store identifier. The MDS determines whether a preferred object store associated with the preferred object store identifier contains a copy of a data object associated with the data object identifier. A write URL comprising the data object identifier and a object store location associated with the preferred object store is transmitted to the client when the preferred object store does not contain the copy of the data object.

Abstract: Cancelling file system operations at a file system client of a distributed file system is disclosed. In various embodiments, an indication is received to send locally-stored file system operations to a remote file system metadata server. A dependency graph or other data structure reflecting dependencies between the locally-stored file system operations is used to identify a set of locally-stored file system operations the members of which are fully dominated by a create-delete pair of operations comprising the set. The locally-stored file system operations comprising the set are cancelled, without being sent to the remote file system metadata server.

Abstract: Techniques to eliminate redundant file system operations are disclosed. In various embodiments, an indication is received to send locally-stored file system operations to a remote file system metadata server. A set of related locally-stored file system operations is determined. Operations in the set are determined to satisfy a merger criteria and are merged into a single merged file system operation. The merged file system operation is sent to the remote file system metadata server.

Abstract: Techniques to manage the use of hash functions are disclosed. In various embodiments, a hash function epoch metadata is stored to associate a hash function with an epoch, the epoch defining a subset of data stored by a distributed file system. The distributed file system is configured to use the hash function epoch metadata to manage storage of data comprising the subset of data stored by the distributed file system.

Abstract: Providing disaster recovery of a distribute file system metadata server as a service is disclosed. In various embodiments, an indication is received to provide alternative access to a file system metadata server. A copy of a self-describing backup of the file system metadata server is obtained, e.g., from cloud-based storage. The backup is used to provide access to a read only instance of the file system metadata server.

Abstract: Systems and methods for protecting and deduplicating streams of data in a cloud based platform. A platform is configured with multiple services and can communicate with multiple clients. The platform receives all requests at an endpoint and distributes the requests to workers using multiple queues. The platform may be stateless and is scalable. The meta-data is handled separately from the data in one example.

Abstract: Systems and methods for protecting and deduplicating streams of data in a cloud based platform. A platform is configured with multiple services and can communicate with multiple clients. The platform receives all requests at an endpoint and distributes the requests to workers using multiple queues. The platform may be stateless and is scalable. The meta-data is handled separately from the data in one example.

Abstract: A method, article of manufacture, and apparatus for limited deduplication scope on a distributed file system is discussed. A write request is received from a client at the metadata server (“MDS”), where the write request comprises a data object identifier and a preferred object store identifier. The MDS determines whether a preferred object store associated with the preferred object store identifier contains a copy of a data object associated with the data object identifier. A write URL comprising the data object identifier and a object store location associated with the preferred object store is transmitted to the client when the preferred object store does not contain the copy of the data object.

Abstract: A method, article of manufacture, and apparatus for limited deduplication scope on a distributed file system is discussed. A write request is received from a client at the metadata server (“MDS”), where the write request comprises a data object identifier and a preferred object store identifier. The MDS determines whether a preferred object store associated with the preferred object store identifier contains a copy of a data object associated with the data object identifier. A write URL comprising the data object identifier and a object store location associated with the preferred object store is transmitted to the client when the preferred object store does not contain the copy of the data object.

Abstract: A method, article of manufacture, and apparatus for providing a site cache in a distributed file system is discussed. Data objects may be written to a site cache prior to writing them to an authoritative object store. This provides performance benefits when a client writing the data has a better connection to the site cache than to the authoritative object store.

Abstract: The present disclosure provides immunogenic compositions and methods for vaccination with a CelTOS immunogen. The immunogenic composition comprises Babesia, Theileria or Cytauxzoon CelTOS. The immunogenic composition may also comprise CelTOS with structural changes that affect immune recognition.