Patents by Inventor Niranjan Sardesai

Niranjan Sardesai has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • DNA monoclonal antibodies targeting checkpoint molecules
    Patent number: 11896654
    Abstract: Disclosed herein is a composition including a recombinant nucleic acid sequence that encodes an antibody or fragment thereof that targets an immune checkpoint molecule. The disclosure also provides a method of preventing and/or treating disease in a subject using said composition and method of generation.
    Type: Grant
    Filed: May 5, 2017
    Date of Patent: February 13, 2024
    Assignees: The Trustees of the University of Pennsylvania, The Wistar Institute of Anatomy and Biology, Inovio Pharmaceuticals
    Inventors: David B. Weiner, Kar Muthumani, Niranjan Sardesai
  • DNA ANTIBODY CONSTRUCTS AND METHOD OF USING SAME
    Publication number: 20230023093
    Abstract: Disclosed herein is a composition including a recombinant nucleic acid sequence that encodes an antibody. Also disclosed herein is a method of generating a synthetic antibody in a subject by administering the composition to the subject. The disclosure also provides a method of preventing and/or treating disease in a subject using said composition and method of generation.
    Type: Application
    Filed: March 3, 2022
    Publication date: January 26, 2023
    Inventors: David B. Weiner, Karuppiah Muthumani, Seleeke Flingai, Niranjan Sardesai
  • DNA Antibody Constructs And Method Of Using Same
    Publication number: 20220112273
    Abstract: Disclosed herein is a composition including a recombinant nucleic acid sequence that encodes an antibody. Also disclosed herein is a method of generating a synthetic antibody in a subject by administering the composition to the subject. The disclosure also provides a method of preventing and/or treating disease in a subject using said composition and method of generation.
    Type: Application
    Filed: December 17, 2021
    Publication date: April 14, 2022
    Inventors: David Weiner, Karuppiah Muthumani, Seleeke Flingai, Niranjan Sardesai
  • DNA antibody constructs and method of using same
    Patent number: 11278619
    Abstract: Disclosed herein is a composition including a recombinant nucleic acid sequence that encodes an antibody. Also disclosed herein is a method of generating a synthetic antibody in a subject by administering the composition to the subject. The disclosure also provides a method of preventing and/or treating disease in a subject using said composition and method of generation.
    Type: Grant
    Filed: December 1, 2015
    Date of Patent: March 22, 2022
    Assignees: The Trustees of the University of Pennsylvania, Inovio Pharmaceuticals, Inc.
    Inventors: David B. Weiner, Karuppiah Muthumani, Seleeke Flingai, Niranjan Sardesai
  • Checkpoint Inhibitor and Vaccine Combinations and Use of Same for Immunotherapy
    Publication number: 20210401978
    Abstract: Disclosed herein is a vaccine comprising an antigen and checkpoint inhibitor. Also disclosed herein is a method for enhancing an immune response in a subject. The method may comprise administering the vaccine to the subject in need thereof.
    Type: Application
    Filed: September 14, 2021
    Publication date: December 30, 2021
    Inventors: David Weiner, Karuppiah Muthumani, Niranjan Sardesai
  • DNA antibody constructs and method of using same
    Patent number: 11208470
    Abstract: Disclosed herein is a composition including a recombinant nucleic acid sequence that encodes an antibody. Also disclosed herein is a method of generating a synthetic antibody in a subject by administering the composition to the subject. The disclosure also provides a method of preventing and/or treating disease in a subject using said composition and method of generation.
    Type: Grant
    Filed: September 26, 2018
    Date of Patent: December 28, 2021
    Assignees: The Trustees of the University of Pennsylvania, Inovio Pharmaceuticals, Inc.
    Inventors: David Weiner, Karuppiah Muthumani, Seleeke Flingai, Niranjan Sardesai
  • Checkpoint inhibitor and vaccine combinations and use of same for immunotherapy
    Patent number: 11116838
    Abstract: Disclosed herein is a vaccine comprising an antigen and checkpoint inhibitor. Also disclosed herein is a method for enhancing an immune response in a subject. The method may comprise administering the vaccine to the subject in need thereof.
    Type: Grant
    Filed: January 28, 2016
    Date of Patent: September 14, 2021
    Assignees: The Trustees of the University of Pennsylvania, INOVIO PHARMACEUTICALS, INC.
    Inventors: David Weiner, Karuppiah Muthumani, Niranjan Sardesai
  • PD1 AND PDL1 ANTIBODIES AND VACCINE COMBINATIONS AND USE OF SAME FOR IMMUNOTHERAPY
    Publication number: 20210085779
    Abstract: Disclosed herein is a vaccine comprising an antigen and PD1 antibody and/or PDL1 antibody. Also disclosed herein is a method for enhancing an immune response in a subject. The method may comprise administering the vaccine to the subject in need thereof.
    Type: Application
    Filed: October 6, 2020
    Publication date: March 25, 2021
    Inventors: David WEINER, Karuppiah MUTHUMANI, Niranjan SARDESAI
  • PD1 and PDL1 antibodies and vaccine combinations and use of same for immunotherapy
    Patent number: 10835595
    Abstract: Disclosed herein is a vaccine comprising an antigen and PD1 antibody and/or PDL1 antibody. Also disclosed herein is a method for enhancing an immune response in a subject. The method may comprise administering the vaccine to the subject in need thereof.
    Type: Grant
    Filed: January 6, 2015
    Date of Patent: November 17, 2020
    Assignees: THE TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA, INOVIO PHARMACEUTICALS, INC.
    Inventors: David Weiner, Karuppiah Muthumani, Niranjan Sardesai
  • DNA Monoclonal Antibodies Targeting Checkpoint Molecules
    Publication number: 20190142920
    Abstract: Disclosed herein is a composition including a recombinant nucleic acid sequence that encodes an antibody or fragment thereof that targets an immune checkpoint molecule. The disclosure also provides a method of preventing and/or treating disease in a subject using said composition and method of generation.
    Type: Application
    Filed: May 5, 2017
    Publication date: May 16, 2019
    Inventors: David B. Weiner, Karuppiah Muthumani, Niranjan Sardesai
  • DNA ANTIBODY CONSTRUCTS AND METHOD OF USING SAME
    Publication number: 20190091322
    Abstract: Disclosed herein is a composition comprising the combination of a nucleic acid sequence encoding a desired polypeptide that elicits an immune response in a mammal and a nucleic acid sequence encoding an antibody, a fragment thereof, a variant thereof, or a combination thereof.
    Type: Application
    Filed: March 21, 2017
    Publication date: March 28, 2019
    Inventors: David B. Weiner, Karuppiah Muthumani, Seleeke Flingai, Niranjan Sardesai, Sarah Elliott, Jian Yan, Ami Patel
  • DNA Antibody Constructs And Method Of Using Same
    Publication number: 20190085058
    Abstract: Disclosed herein is a composition including a recombinant nucleic acid sequence that encodes an antibody. Also disclosed herein is a method of generating a synthetic antibody in a subject by administering the composition to the subject. The disclosure also provides a method of preventing and/or treating disease in a subject using said composition and method of generation.
    Type: Application
    Filed: September 26, 2018
    Publication date: March 21, 2019
    Inventors: David Weiner, Karuppiah Muthumani, Seleeke Flingai, Niranjan Sardesai
  • DNA ANTIBODY CONSTRUCTS AND METHOD OF USING SAME
    Publication number: 20180346554
    Abstract: Disclosed herein is a composition including a recombinant nucleic acid sequence that encodes an antibody. Also disclosed herein is a method of generating a synthetic antibody in a subject by administering the composition to the subject. The disclosure also provides a method of preventing and/or treating disease in a subject using said composition and method of generation.
    Type: Application
    Filed: June 12, 2018
    Publication date: December 6, 2018
    Inventors: David B. Weiner, Kar Muthumani, Niranjan Sardesai, Seleeke Flingai
  • Novel Vaccines Against Multiple Subtypes Of Dengue Virus
    Publication number: 20180326037
    Abstract: An aspect of the present invention is related to nucleic acid constructs capable of expressing a polypeptide, such as a consensus dengue prME that elicits an immune response in a mammal against more than one subtype of dengue virus, and methods of use thereof. Additionally, there are DNA plasmid vaccines capable of generating in a mammal an immune response against a plurality of dengue virus subtypes, comprising a DNA plasmid and a pharmaceutically acceptable excipient, and methods of use thereof. The DNA plasmid is capable of expressing a consensus dengue antigen in a cell of the mammal in a quantity effective to elicit an immune response in the mammal that is cross reactive against all 4 dengue subtypes.
    Type: Application
    Filed: May 17, 2018
    Publication date: November 15, 2018
    Inventors: David B. Weiner, Jian Yan, Niranjan Sardesai
  • DNA antibody constructs and method of using same
    Patent number: 10087240
    Abstract: The present invention relates to a composition including a recombinant nucleic acid sequence that encodes an antibody and a method of generating a synthetic antibody in a subject by administering the composition to the subject. The invention also provides a method of preventing and/or treating disease in a subject using the composition and method of generation.
    Type: Grant
    Filed: December 13, 2014
    Date of Patent: October 2, 2018
    Assignee: INOVIO PHARMACEUTICALS, INC.
    Inventors: David Weiner, Karuppiah Muthumani, Seleeke Flingai, Niranjan Sardesai
  • Compositions and methods for generating a synthetic antibody
    Patent number: 9994629
    Abstract: Disclosed herein is a composition including a recombinant nucleic acid sequence that encodes an antibody. Also disclosed herein is a method of generating a synthetic antibody in a subject by administering the composition to the subject. The disclosure also provides a method of preventing and/or treating disease in a subject using said composition and method of generation.
    Type: Grant
    Filed: December 13, 2013
    Date of Patent: June 12, 2018
    Assignee: THE TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA
    Inventors: David B. Weiner, Karuppiah Muthumani, Niranjan Sardesai, Seleeke Flingai
  • Vaccines against multiple subtypes of dengue virus
    Patent number: 9987347
    Abstract: An aspect of the present invention is related to nucleic acid constructs capable of expressing a polypeptide, such as a consensus dengue prME that elicits an immune response in a mammal against more than one subtype of dengue virus, and methods of use thereof. Additionally, there are DNA plasmid vaccines capable of generating in a mammal an immune response against a plurality of dengue virus subtypes, comprising a DNA plasmid and a pharmaceutically acceptable excipient, and methods of use thereof. The DNA plasmid is capable of expressing a consensus dengue antigen in a cell of the mammal in a quantity effective to elicit an immune response in the mammal that is cross reactive against all 4 dengue subtypes.
    Type: Grant
    Filed: March 14, 2014
    Date of Patent: June 5, 2018
    Assignees: THE TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA, INOVIO PHARMACEUTICALS, INC.
    Inventors: David B. Weiner, Jian Yan, Niranjan Sardesai
  • Checkpoint Inhibitor and Vaccine Combinations and Use of Same For Immunotherapy
    Publication number: 20180015161
    Abstract: Disclosed herein is a vaccine comprising an antigen and checkpoint inhibitor. Also disclosed herein is a method for enhancing an immune response in a subject. The method may comprise administering the vaccine to the subject in need thereof.
    Type: Application
    Filed: January 28, 2016
    Publication date: January 18, 2018
    Inventors: David Weiner, Karuppiah Muthumani, Niranjan Sardesai
  • DNA ANTIBODY CONSTRUCTS AND METHOD OF USING SAME
    Publication number: 20170266282
    Abstract: Disclosed herein is a composition including a recombinant nucleic acid sequence that encodes an antibody. Also disclosed herein is a method of generating a synthetic antibody in a subject by administering the composition to the subject. The disclosure also provides a method of preventing and/or treating disease in a subject using said composition and method of generation.
    Type: Application
    Filed: December 1, 2015
    Publication date: September 21, 2017
    Applicants: Inovio Pharmaceuticals, Inc., The Trustees of the University of Pennsylvania
    Inventors: David B. Weiner, Karuppiah Muthumani, Seleeke Flingai, Niranjan Sardesai
  • PD1 AND PDL1 ANTIBODIES AND VACCINE COMBINATIONS AND USE OF SAME FOR IMMUNOTHERAPY
    Publication number: 20170007693
    Abstract: Disclosed herein is a vaccine comprising an antigen and PD1 antibody and/or PDL1 antibody. Also disclosed herein is a method for enhancing an immune response in a subject. The method may comprise administering the vaccine to the subject in need thereof.
    Type: Application
    Filed: January 6, 2015
    Publication date: January 12, 2017
    Inventors: David WEINER, Karupplah MUTHUMANI, Niranjan SARDESAI