Patents by Inventor Niranjana D. Amin

Niranjana D. Amin has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • TP5, A PEPTIDE INHIBITOR OF ABERRANT AND HYPERACTIVE CDK5/P25 AS TREATMENT FOR CANCER
    Publication number: 20220009980
    Abstract: Methods of decreasing cell viability of cancer cells, increasing apoptosis of cancer cells, and treating cancer in a mammal with cancer are provided. The methods include administering (i) a polypeptide comprising an amino acid sequence with at least 95% sequence identity to the amino acid sequence of SEQ ID NO: 1, (ii) a nucleic acid molecule comprising a nucleic acid sequence encoding the polypeptide, (iii) a vector comprising the nucleic acid molecule, (iv) a recombinant cell comprising any one of (i)-(iii), and/or (v) a composition comprising any one of (i)-(iv).
    Type: Application
    Filed: November 13, 2019
    Publication date: January 13, 2022
    Applicant: The United States of America,as represented by the Secretary,Department of Health and Human Services
    Inventors: Zhengping Zhuang, Emeline Tabouret, Herui Wang, Harish Pant, Niranjana D. Amin
  • Therapeutic approach to neurodegenerative disorders using a TFP5-peptide
    Patent number: 8597660
    Abstract: Disclosed herein are isolated peptides, pharmaceutical compositions and methods for use of such for treating subjects with a neurodegenerative disease, such as Alzheimer's. In an example, an isolated polypeptide includes a cyclin dependent kinase 5 (Cdk5) inhibitory domain that has at least 95% sequence identity to the amino acid sequence set forth as SEQ ID NO: 1, wherein the Cdk5 inhibitory domain is linked to a protein transduction domain. Methods of reducing or inhibiting one or more symptoms associated with a neurodegenerative disease by administering a therapeutically effective amount of a pharmaceutical composition including one or more disclosed peptides are also provided.
    Type: Grant
    Filed: September 29, 2011
    Date of Patent: December 3, 2013
    Assignee: The United States of America, as represented by the Secretary, Department of Health and Human Services
    Inventors: Harish C. Pant, Ya-li Zheng, Niranjana D. Amin, Philip Grant, Parvathi Rudrabhatla, Varsha Shukla, Sashi Kesavapany
  • THERAPEUTIC APPROACH TO NEURODEGENERATIVE DISORDERS USING A TFP5-PEPTIDE
    Publication number: 20120115790
    Abstract: Disclosed herein are isolated peptides, pharmaceutical compositions and methods for use of such for treating subjects with a neurodegenerative disease, such as Alzheimer's. In an example, an isolated polypeptide includes a cyclin dependent kinase 5 (Cdk5) inhibitory domain that has at least 95% sequence identity to the amino acid sequence set forth as SEQ ID NO: 1, wherein the Cdk5 inhibitory domain is linked to a protein transduction domain. Methods of reducing or inhibiting one or more symptoms associated with a neurodegenerative disease by administering a therapeutically effective amount of a pharmaceutical composition including one or more disclosed peptides are also provided.
    Type: Application
    Filed: September 29, 2011
    Publication date: May 10, 2012
    Inventors: Harish C. Pant, Ya-li Zheng, Niranjana D. Amin, Philip Grant, Parvathi Rudrabhatla, Varsha Shukla, Sashi Kesavapany