Patents by Inventor Niren Murthy

Niren Murthy has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Publication number: 20200368206
    Abstract: The present disclosure provides endosomal disruptors, which are useful for facilitating delivery of a macromolecule to the cytoplasm of a cell. The present disclosure provides compositions comprising an endosomal disruptor and a macromolecule. The present disclosure provides methods of delivering a macromolecule to the cytoplasm of a cell.
    Type: Application
    Filed: December 3, 2018
    Publication date: November 26, 2020
    Inventors: Niren Murthy, Joachim Justad Roeise, Chung Hak Taing
  • Publication number: 20200316352
    Abstract: Provided are active agent delivery devices configured to deliver an active agent formulation into or through a mucosal layer in a subject. The active agent delivery devices include a power reservoir configured to eject the active agent formulation at a pressure sufficient to deliver the active agent formulation into or through a mucosal layer in a subject. Methods of using the subject active agent delivery devices are also provided.
    Type: Application
    Filed: June 23, 2020
    Publication date: October 8, 2020
    Inventors: Kiana Aran, Jacobo Paredes, Niren Murthy, Dorian Liepmann, Kunwoo Lee
  • Patent number: 10729895
    Abstract: Provided are active agent delivery devices configured to deliver an active agent formulation into or through a mucosal layer in a subject. The active agent delivery devices include a power reservoir configured to eject the active agent formulation at a pressure sufficient to deliver the active agent formulation into or through a mucosal layer in a subject. Methods of using the subject active agent delivery devices are also provided.
    Type: Grant
    Filed: September 29, 2015
    Date of Patent: August 4, 2020
    Assignee: The Regents of the University of California
    Inventors: Kiana Aran, Jacobo Paredes, Niren Murthy, Dorian Liepmann, Kunwoo Lee
  • Publication number: 20200188476
    Abstract: The present disclosure provides a conjugate comprising an anti-microbial agent and a hydrophilic polymer; and compositions, including pharmaceutical compositions, comprising the conjugates. The present disclosure provides a conjugate comprising a polymyxin covalently linked to a maltodextrin polymer; and compositions, including pharmaceutical compositions, comprising the conjugates. The present disclosure provides methods of inhibiting growth of a bacterium, and methods of treating a bacterial infection.
    Type: Application
    Filed: April 17, 2018
    Publication date: June 18, 2020
    Inventors: Niren Murthy, Jingtuo Zhang, Giri K. Vegesna, Bora Park
  • Patent number: 10646580
    Abstract: This disclosure relates to conjugates for targeting bacteria and related uses. In certain embodiments, the disclosure relates to methods of transferring a molecule of interest into bacteria comprising mixing bacteria with a non-naturally occurring conjugate under conditions such that the conjugate is transported across the bacterial cell wall. Typically, the conjugate comprises an oligosaccharide and a molecule of interest. In certain embodiments, the molecule of interest may be a tracer or an antibiotic.
    Type: Grant
    Filed: November 2, 2017
    Date of Patent: May 12, 2020
    Assignees: Emory University, Georgia Tech Research Corporation, Georgia State University Research Foundation, Inc.
    Inventors: Niren Murthy, Eric Seth Gilbert, Xinghai Ning, Mark Goodman, Bryan Stubblefield
  • Publication number: 20200085785
    Abstract: Aspects of the present disclosure include antibacterial aromatic sulfonyl fluoride agents. The subject aromatic sulfonyl fluoride agents have a pharmacophore that can provide for potent antibacterial activity. The subject agents are compounds including an aromatic group substituted with a sulfonyl fluoride warhead group and an electron withdrawing group. The subject agents find use in a variety of antibiotic applications. In some cases, the subject agents find use in methods of treating bacterial infections in a subject. Also provided are pharmaceutical compositions and kits that find use in practicing the subject methods.
    Type: Application
    Filed: June 27, 2018
    Publication date: March 19, 2020
    Inventors: Niren Murthy, Corinne Sadlowski, Bora Park
  • Publication number: 20190376972
    Abstract: Diagnostic assays and methods employ a dual-enzyme cascade system comprised of two enzymatic amplifiers and two molecular probes, by (a) incubating a target enzyme with a target enzyme substrate to liberate a thiol; (b) incubating the thiol with a disulfide inactivated amplification enzyme to activate the amplification enzyme in an interchange reaction of the thiol and the disulfide; and (c) incubating the activated amplification enzyme with an amplification enzyme substrate to generate an amplified signal.
    Type: Application
    Filed: August 14, 2019
    Publication date: December 12, 2019
    Applicant: The Regents of the University of California
    Inventors: Niren Murthy, Lee W. Riley, Tara Renee BeBoer
  • Publication number: 20190314506
    Abstract: Compositions and methods are described for a polymer hydrogel created by a cycloaddition reaction between an azide and an alkyne that proceeds rapidly without catalyst to produce the polymer hydrogel in less than ninety seconds. The polymer hydrogel can be used in in vivo applications for the localized delivery of therapeutic agent in aqueous solutions. An example of therapeutic delivery of a protein in a mouse model is demonstrated.
    Type: Application
    Filed: July 3, 2018
    Publication date: October 17, 2019
    Applicants: Georgia Tech Research Corporation, Children's Healthcare of Atlanta, Inc.
    Inventors: Niren Murthy, Christopher Hermann, David Scott Wilson, Xinghai Ning, Barbara D. Boyan, Zvi Schwartz, Robert Guldberg, Tamim Diab
  • Publication number: 20180237800
    Abstract: The present disclosure provides a complex comprising a nanoparticle; a Type II or a Type V CRISPR system comprising a site-directed DNA-modifying polypeptide and a guide RNA; and a polycation-based endosomal escape polymer. The present disclosure provides methods of making and using a complex of the present disclosure.
    Type: Application
    Filed: September 20, 2016
    Publication date: August 23, 2018
    Inventors: Niren Murthy, Kunwoo Lee, Irina M. Conboy, Michael J. Conboy
  • Patent number: 10039831
    Abstract: Compositions and methods are described for a polymer hydrogel created by a cycloaddition reaction between an azide and an alkyne that proceeds rapidly without catalyst to produce the polymer hydrogel in less than ninety seconds. The polymer hydrogel can be used in in vivo applications for the localized delivery of therapeutic agent in aqueous solutions. An example of therapeutic delivery of a protein in a mouse model is demonstrated.
    Type: Grant
    Filed: March 19, 2012
    Date of Patent: August 7, 2018
    Assignees: Georgia Tech Research Corporation, Children's Healthcare of Atlanta, Inc.
    Inventors: Niren Murthy, Christopher Hermann, David Scott Wilson, Xinghai Ning, Barbara D. Boyan, Zvi Schwartz, Robert Guldberg, Tamim Diab
  • Publication number: 20180125991
    Abstract: This disclosure relates to conjugates for targeting bacteria and related uses. In certain embodiments, the disclosure relates to methods of transferring a molecule of interest into bacteria comprising mixing bacteria with a non-naturally occurring conjugate under conditions such that the conjugate is transported across the bacterial cell wall. Typically, the conjugate comprises an oligosaccharide and a molecule of interest. In certain embodiments, the molecule of interest may be a tracer or an antibiotic.
    Type: Application
    Filed: November 2, 2017
    Publication date: May 10, 2018
    Inventors: Niren Murthy, Eric Seth Gilbert, Xinghai Ning, Mark Goodman, Bryan Stubblefield
  • Patent number: 9821071
    Abstract: This disclosure relates to conjugates for targeting bacteria and related uses. In certain embodiments, the disclosure relates to methods of transferring a molecule of interest into bacteria comprising mixing bacteria with a non-naturally occurring conjugate under conditions such that the conjugate is transported across the bacterial cell wall. Typically, the conjugate comprises an oligosaccharide and a molecule of interest. In certain embodiments, the molecule of interest may be a tracer or an antibiotic.
    Type: Grant
    Filed: February 26, 2014
    Date of Patent: November 21, 2017
    Assignees: Emory University, Georgia Tech Research Corporation, Georgia State University Research Foundation, Inc.
    Inventors: Niren Murthy, Eric Seth Gilbert, Xinghai Ning, Mark Goodman, Bryan Stubblefield
  • Publication number: 20170274087
    Abstract: This disclosure relates saccharide analogs such as thiomaltose-based analogs for targeting bacteria and related uses. In certain embodiments, the disclosure relates to methods of transferring a molecule of interest into bacteria comprising mixing bacteria with a non-naturally occurring conjugate, wherein the conjugate comprises a thiomaltose-based analog and a molecule of interest under conditions such that the conjugate is transported across the bacterial cell wall. In certain embodiments, the molecule of interest can be a tracer or an antibiotic.
    Type: Application
    Filed: September 21, 2015
    Publication date: September 28, 2017
    Inventors: Mark Goodman, Robert W. Taylor, Kiyoko Takemiya, Niren Murthy, Rafi Mohammed, Xinghai Ning
  • Publication number: 20170246438
    Abstract: Provided are active agent delivery devices configured to deliver an active agent formulation into or through a mucosal layer in a subject. The active agent delivery devices include a power reservoir configured to eject the active agent formulation at a pressure sufficient to deliver the active agent formulation into or through a mucosal layer in a subject. Methods of using the subject active agent delivery devices are also provided.
    Type: Application
    Filed: September 29, 2015
    Publication date: August 31, 2017
    Inventors: Kiana Aran, Jacobo Paredes, Niren Murthy, Dorian Liepmann, Kunwoo Lee
  • Patent number: 9585958
    Abstract: The present disclosure provides methods of reducing levels of lactate in a fluid or tissue in an individual. The present disclosure provides pharmaceutical compositions suitable for use in the methods.
    Type: Grant
    Filed: September 19, 2014
    Date of Patent: March 7, 2017
    Inventors: Abhinav P. Acharya, Niren Murthy, Elliot C. Woods
  • Publication number: 20150105348
    Abstract: The present disclosure provides methods of reducing levels of lactate in a fluid or tissue in an individual. The present disclosure provides pharmaceutical compositions suitable for use in the methods.
    Type: Application
    Filed: September 19, 2014
    Publication date: April 16, 2015
    Inventors: Abhinav P. Acharya, Niren Murthy, Elliot C. Woods
  • Patent number: 8846106
    Abstract: Compositions and methods for transport or release of therapeutic and diagnostic agents or metabolites or other analytes from cells, compartments within cells, or through cell layers or barriers are described. The compositions include a membrane barrier transport enhancing agent and are usually administered in combination with an enhancer and/or exposure to stimuli to effect disruption or altered permeability, transport or release. In a preferred embodiment, the compositions include compounds which disrupt endosomal membranes in response to the low pH in the endosomes but which are relatively inactive toward cell membranes, coupled directly or indirectly to a therapeutic or diagnostic agent. Other disruptive agents can also be used, responsive to stimuli and/or enhancers other than pH, such as light, electrical stimuli, electromagnetic stimuli, ultrasound, temperature, or combinations thereof.
    Type: Grant
    Filed: July 14, 2011
    Date of Patent: September 30, 2014
    Assignees: University of Washington, University of Massachusetts
    Inventors: Allan S. Hoffman, Patrick Stayton, Oliver W. Press, Niren Murthy, Chantal Lackey Reed, Lawrence A. Crum, Pierre D. Mourad, Tyrone M. Porter, David Tirrell
  • Patent number: 8815860
    Abstract: The present disclosure is generally related to methods of preventing oxidative stress injury induced by renal ischemia-reperfusion by a Folate-TEMPOL conjugate.
    Type: Grant
    Filed: September 21, 2010
    Date of Patent: August 26, 2014
    Assignees: Emory University, Georgia Tech Research Corporation
    Inventors: W. Robert Taylor, Sarah F. Knight, Niren Murthy, Kousik Kundu
  • Publication number: 20140219950
    Abstract: Compositions and methods for transport or release of therapeutic and diagnostic agents or metabolites or other analytes from cells, compartments within cells, or through cell layers or barriers are described. The compositions include a membrane barrier transport enhancing agent and are usually administered in combination with an enhancer and/or exposure to stimuli to effect disruption or altered permeability, transport or release. In a preferred embodiment, the compositions include compounds which disrupt endosomal membranes in response to the low pH in the endosomes but which are relatively inactive toward cell membranes, coupled directly or indirectly to a therapeutic or diagnostic agent. Other disruptive agents can also be used, responsive to stimuli and/or enhancers other than pH, such as light, electrical stimuli, electromagnetic stimuli, ultrasound, temperature, or combinations thereof.
    Type: Application
    Filed: February 7, 2014
    Publication date: August 7, 2014
    Applicants: UNIVERSITY OF MASSACHUSETTS, UNIVERSITY OF WASHINGTON
    Inventors: Allan S. Hoffman, Patrick Stayton, Oliver W. Press, Niren Murthy, Chantal Lackey Reed, Lawrence A. Crum, Pierre D. Mourad, Tyrone M. Porter, David Tirrell
  • Publication number: 20140219917
    Abstract: This disclosure relates to conjugates for targeting bacteria and related uses. In certain embodiments, the disclosure relates to methods of transferring a molecule of interest into bacteria comprising mixing bacteria with a non-naturally occurring conjugate under conditions such that the conjugate is transported across the bacterial cell wall. Typically, the conjugate comprises an oligosaccharide and a molecule of interest. In certain embodiments, the molecule of interest may be a tracer or an antibiotic.
    Type: Application
    Filed: February 26, 2014
    Publication date: August 7, 2014
    Applicants: Emory University, Georgia State Research Foundation, Georgia Tech Research Corporation
    Inventors: Niren MURTHY, Eric Seth Gilbert, Xinghai Ning, Mark Goodman, Bryan Stubblefield