Patents by Inventor Niro Inaba

Niro Inaba has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Patent number: 8431365
    Abstract: The N-acetyl-D-galactosamine transferase protein of the present invention is characterized by transferring N-acetyl-D-galactosamine to N-acetyl-D-glucosamine with ?1,3 linkage, and it preferably has the amino acid sequence shown in SEQ ID NO: 2 or 4. The canceration assay according to the present invention uses a nucleic acid for measurement which hybridizes under stringent conditions to the nucleotide sequence shown in SEQ ID NO: 1 or 3 or a nucleotide sequence complementary to at least one of them.
    Type: Grant
    Filed: June 29, 2012
    Date of Patent: April 30, 2013
    Assignee: National Institute of Advanced Industrial Science and Technology
    Inventors: Hisashi Narimatsu, Akira Togayachi, Niro Inaba, Toru Hiruma, Yasuko Ishizuka
  • Publication number: 20130004995
    Abstract: The N-acetyl-D-galactosamine transferase protein of the present invention is characterized by transferring N-acetyl-D-galactosamine to N-acetyl-D-glucosamine with ?1,3 linkage, and it preferably has the amino acid sequence shown in SEQ ID NO: 2 or 4. The canceration assay according to the present invention uses a nucleic acid for measurement which hybridizes under stringent conditions to the nucleotide sequence shown in SEQ ID NO: 1 or 3 or a nucleotide sequence complementary to at least one of them.
    Type: Application
    Filed: June 29, 2012
    Publication date: January 3, 2013
    Applicant: National Institute of Advanced Science & Technology
    Inventors: Hisashi NARIMATSU, Akira Togayachi, Niro Inaba, Toru Hiruma, Yasuko Ishizuka
  • Patent number: 8227213
    Abstract: The N-acetyl-D-galactosamine transferase protein of the present invention is characterized by transferring N-acetyl-D-galactosamine to N-acetyl-D-glucosamine with ?1,3 linkage, and it preferably has the amino acid sequence shown in SEQ ID NO: 2 or 4. The canceration assay according to the present invention uses a nucleic acid for measurement which hybridizes under stringent conditions to the nucleotide sequence shown in SEQ ID NO: 1 or 3 or a nucleotide sequence complementary to at least one of them.
    Type: Grant
    Filed: April 30, 2010
    Date of Patent: July 24, 2012
    Assignee: National Institute of Advanced Science & Technology
    Inventors: Hisashi Narimatsu, Akira Togayachi, Niro Inaba, Toru Hiruma, Yasuko Ishizuka
  • Publication number: 20100279355
    Abstract: The N-acetyl-D-galactosamine transferase protein of the present invention is characterized by transferring N-acetyl-D-galactosamine to N-acetyl-D-glucosamine with ?1,3 linkage, and it preferably has the amino acid sequence shown in SEQ ID NO: 2 or 4. The canceration assay according to the present invention uses a nucleic acid for measurement which hybridizes under stringent conditions to the nucleotide sequence shown in SEQ ID NO: 1 or 3 or a nucleotide sequence complementary to at least one of them.
    Type: Application
    Filed: April 30, 2010
    Publication date: November 4, 2010
    Applicant: National Institute of Advanced Industrial Science and Technology
    Inventors: Hisashi NARIMATSU, Akira Togayachi, Niro Inaba, Toru Hiruma, Yasuko Ishizuka
  • Publication number: 20080299615
    Abstract: The N-acetyl-D-galactosamine transferase protein of the present invention is characterized by transferring N-acetyl-D-galactosamine to N-acetyl-D-glucosamine with ?1,3 linkage, and it preferably has the amino acid sequence shown in SEQ ID NO: 2 or 4. The canceration assay according to the present invention uses a nucleic acid for measurement which hybridizes under stringent conditions to the nucleotide sequence shown in SEQ ID NO: 1 or 3 or a nucleotide sequence complementary to at least one of them.
    Type: Application
    Filed: June 30, 2008
    Publication date: December 4, 2008
    Applicant: National Institute of Advanced Industrial Science and Technology
    Inventors: Hisashi Narimatsu, Akira Togayachi, Niro Inaba, Toru Hiruma, Yasuko Ishizuka
  • Patent number: 7323324
    Abstract: Described are an enzyme having an activity to transfer N-acetylglucosamine to N-acetylgalactosaminyl group through a ?1,3-linkage; nucleic acid coding for the enzyme; and method for diagnosis of a cancer and/or tumor, especially a cancer and/or tumor of a digestive organ using the expression amount of the gene of the enzyme as an index. A gene coding for a novel enzyme having an activity to transfer N-acetylglucosamine to N-acetylgalactosaminyl group through the ?1,3-linkage was cloned from human colon and stomach cells, and the gene was sequenced. The enzyme was expressed, and a monoclonal antibody to the enzyme was prepared. Since this enzyme is not produced substantially or at all in cancer and/or tumor cells, especially in cancer or tumor cells of a digestive organ, the cancer and/or tumor may be diagnosed using the expression of the gene of the enzyme as an index.
    Type: Grant
    Filed: October 16, 2002
    Date of Patent: January 29, 2008
    Assignee: National Institute of Advanced Industrial Science and Technology
    Inventors: Hisashi Narimatsu, Niro Inaba, Toshie Iwai
  • Publication number: 20070178557
    Abstract: Described are an enzyme having an activity to transfer N-acetylglucosamine to a non-reducing terminal of Gal?1-4Glc or Gal?1-4GlcNAc group through ?1,3-linkage; nucleic acid coding for the enzyme; and method for diagnosis of a cancer and/or tumor, especially a cancer and/or tumor of a digestive organ, using the expression amount of the gene of the enzyme as an index. A gene coding for a novel enzyme having an activity to transfer N-acetylglucosamine to a non-reducing terminal of Gal?1-4Glc or Gal?1-4GlcNAc group through ?1,3-linkage was cloned from human stomach cells, and sequenced, and the enzyme was expressed. Since this enzyme is not produced substantially or at all in cancer and/or tumor cells, especially in cancer or tumor cells of a digestive organ, the cancer and/or tumor may be diagnosed using the expression of the gene of the enzyme as an index.
    Type: Application
    Filed: March 26, 2007
    Publication date: August 2, 2007
    Inventors: Hisashi Narimatsu, Niro Inaba, Akira Togayachi
  • Patent number: 7223580
    Abstract: An enzyme having an activity of transferring N-acetylglucosamine to the non-reducing end of a Gal?1-4Glc or Gal?1-4GlcNAc-group via a ?-1,3 bond; a nucleic acid encoding the same; and a method of diagnosing cancer and/or tumor, in particular, digestive cancer and/or tumor using the expression dose of a gene of the above enzyme as an indication. A gene of a novel enzyme having an activity of transferring N-acetylglucosamine to the non-reducing end of a Gal ?1-4Glc or Gal ?1-4GlcNAc-group via a ?-1,3 bond is cloned from human stomach cells and its base sequence is determined. Then this enzyme is expressed. Since this enzyme is scarcely or never produced in cancer and/or tumor, in particular, digestive cancer and/or tumor cells, cancer and/or tumor can be diagnosed with the use of the expression of the enzyme gene as an indication.
    Type: Grant
    Filed: March 14, 2003
    Date of Patent: May 29, 2007
    Assignee: National Institute of Advanced Industrial Science and Technology
    Inventors: Hisashi Narimatsu, Niro Inaba, Akira Togayachi
  • Publication number: 20060234220
    Abstract: Described are an enzyme having an activity to transfer N-acetylglucosamine to N-acetylgalactosaminyl group through a ?1,3-linkage; nucleic acid coding for the enzyme; and method for diagnosis of a cancer and/or tumor, especially a cancer and/or tumor of a digestive organ using the expression amount of the gene of the enzyme as an index. A gene coding for a novel enzyme having an activity to transfer N-acetylglucosamine to N-acetylgalactosaminyl group through the ?1,3-linkage was cloned from human colon and stomach cells, and the gene was sequenced. The enzyme was expressed, and a monoclonal antibody to the enzyme was prepared. Since this enzyme is not produced substantially or at all in cancer and/or tumor cells, especially in cancer or tumor cells of a digestive organ, the cancer and/or tumor may be diagnosed using the expression of the gene of the enzyme as an index.
    Type: Application
    Filed: October 16, 2002
    Publication date: October 19, 2006
    Inventors: Hisashi Narimatsu, Niro Inaba, Toshie Iwai
  • Publication number: 20060166211
    Abstract: The N-acetyl-D-galactosamine transferase protein of the present invention is characterized by transferring N-acetyl-D-galactosamine to N-acetyl-D-glucosamine with ?1,3 linkage, and it preferably has the amino acid sequence shown in SEQ ID NO: 2 or 4. The canceration assay according to the present invention uses a nucleic acid for measurement which hybridizes under stringent conditions to the nucleotide sequence shown in SEQ ID NO: 1 or 3 or a nucleotide sequence complementary to at least one of them.
    Type: Application
    Filed: January 23, 2004
    Publication date: July 27, 2006
    Inventors: Hisashi Narimatsu, Akira Togayachi, Niro Inaba, Toru Hiruma, Yasuko Ishizuka
  • Publication number: 20050186570
    Abstract: An enzyme having an activity of transferring N-acetylglucosamine to the non-reducing end of a Gal ?1-4Glc or Gal ?1-4GlcNAc-group via a ?-1,3 bond; a nucleic acid encoding the same; and a method of diagnosing cancer and/or tumor, in particular, digestive cancer and/or tumor using the expression dose of a gene of the above enzyme as an indication. A gene of a novel enzyme having an activity of transferring N-acetylglucosamine to the non-reducing end of a Gal ?1-4Glc or Gal ?1-4GlcNAc-group via a ?-1,3 bond is cloned from human stomach cells and its base sequence is determined. Then this enzyme is expressed. Since this enzyme is scarcely or never produced in cancer and/or tumor, in particular, digestive cancer and/or tumor cells, cancer and/or tumor can be diagnosed with the use of the expression of the enzyme gene as an indication.
    Type: Application
    Filed: March 14, 2003
    Publication date: August 25, 2005
    Applicant: NATIONAL INSTITUTE OF ADVANCED INDUSTRIAL SCIENCE AND TECHNOLOGY
    Inventors: Hisashi Narimatsu, Niro Inaba, Akira Togayachi
  • Publication number: 20050064557
    Abstract: A method for producing a desired protein by genetic engineering process by which the desired protein can easily be recovered without denaturation is disclosed. In this method, the desired protein is produced in the form a fusion protein with a protein constituting a virus particle, and the virus particle is recovered. Since the virus particles are larger than usual protein molecules occurring in the cells, the particles can be easily recovered by centrifugation or the like.
    Type: Application
    Filed: August 2, 2004
    Publication date: March 24, 2005
    Inventors: Niro Inaba, Takeya Hori, Satoru Ito
  • Publication number: 20030191323
    Abstract: The present invention provides a hypoglycemic agent containing an acylsulfonamide derivative such as a compound of the following formula or an analog thereof, which agent is usable for preventing and curing diabetes: 1
    Type: Application
    Filed: January 2, 2003
    Publication date: October 9, 2003
    Applicant: Ajinomoto Co., Inc.
    Inventors: Hiroshi Ikawa, Masato Nishimura, Keiji Okada, Takashi Nakamura, Niro Inaba, Kazuhiro Kojima, Hideki Kosono
  • Publication number: 20030104580
    Abstract: A method for producing a desired protein by genetic engineering process by which the desired protein can easily he recovered without denaturation is disclosed. In this method, the desired protein is produced in the form a fusion protein with a protein constituting a virus particle, and the virus particle is recovered. Since the virus particles are larger than usual protein molecules occurring in the cells, the particles can be easily recovered by centrifugation or the like.
    Type: Application
    Filed: March 5, 2002
    Publication date: June 5, 2003
    Inventors: Niro Inaba, Takeya Hori, Satoru Ito
  • Patent number: 5219841
    Abstract: The present invention relates to a pharmaceutical composition for treating a heart disease which comprises a therapeutically effective amount of diadenosine 5',5'"-P.sup.1, P.sup.4 -tetraphosphate as an active ingredient in admixture with a pharmaceutically acceptable carrier or diluent. The pharmaceutical composition is particularly characterized by having antiarrhythmic and coronary vasodilative activities. The present invention also relates to a method for treating a subject having a heart disease or particularly arrhythmia, which comprises administering to the subject an effective amount of the pharmaceutical composition.
    Type: Grant
    Filed: November 20, 1990
    Date of Patent: June 15, 1993
    Assignees: Fujirebio, Inc., Unitika Ltd.
    Inventors: Niro Inaba, Kunihiro Okamura, Tetsuaki Yamaura