Abstract: A dry multilayer analysis element which allows easy permeation of a high molecular weight component or hydrophobic component, which has, in order, at least a water permeable porous reagent layer, a water permeable light reflecting/screen layer, and a water permeable porous spreading layer on a water-impermeable transparent support, a reagent composition capable of producing an optically detectable substance in the presence of a component to be detected being incorporated in at least one of the water-permeable layers including said reagent layer, said light reflecting/screen layer being porous and comprised microcapsules having a core containing light reflective/screen grains and a shell made of a high molecular weight compound, wherein each of said reagent layer, spreading layer, and reflecting/screen layer allows permeation of a high molecular weight or hydrophobic component therethrough.