Abstract: We queried DNA from saliva or plasma of 93 HNSCC patients, searching for somatic mutations or human papillomavirus genes, collectively referred to as tumor DNA. When both plasma and saliva were tested, tumor DNA was detected in 96% (95% CI, 84% to 99%) of 47 patients. The fractions of patients with detectable tumor DNA in early- and late-stage disease were 100% (n=10) and 95% (n=37), respectively. Saliva is preferentially enriched for tumor DNA from the oral cavity, whereas plasma is preferentially enriched for tumor DNA from the other sites. Tumor DNA in the saliva and plasma is a valuable biomarker for detection of HNSCC.

Abstract: One aspect of the present disclosure is directed to a computer-implemented system for streamlined product searching configured to receive a search query comprising at least one keyword; determine a product type; retrieve a first record of products associated with the product type; determine whether the search query meets a condition; and if the search query meets the condition: determine, a plurality of label values, and for each label value: generate a second record of products associated with the label value; determine whether each product in the second record meets a condition; deleting each product that meets the condition from the second record; ranking each remaining product in each second record; display the plurality of label values for selection; receive a selected label value; and display at least a portion of the remaining ranked products associated with the selected label value.

Abstract: A computerized system and method for dynamically generating modified user interface is disclosed. The method comprises receiving a search request, providing a list of at least one product in response to the search request, receiving a selection of a first product from the user device, providing the first product to the user device for display on the user interface, determining signals of the first product and their weights, calculating a score for each of the second products based on signals of the first product, ranking the second products by the score, and in response to receiving a request to redisplay the list of product, providing, to the user device for display together with the list of product, at least one second product based on the ranking.

Abstract: Described herein is a method for evaluating a subject comprising detecting genetic mutation(s) in the DNA sequence of one or more oral cavity squamous cell carcinoma (OCSCC) biomarker(s) in a biological sample from the subject comprising DNA, wherein the OCSCC biomarker(s) comprise TP53, CDKN2A, FAT1, CASP8, NOTCH1, PIK3CA, and/or ERAS.

Abstract: Methods and system for generating a filter interface in response to a user search are disclosed. The method includes extracting keywords from a search term, determining a plurality of filters associated with the keywords, determining a ranking for each of the plurality of filters, providing and displaying, based on the ranking, a subset of the plurality of filters as exposed filters, receiving a user selection of one of the exposed filters, in response to the second user input, applying the one of the plurality of filters and updating the ranking of the remaining of the plurality of filters, updating, to the first user, the search result, and regenerating the plurality of filters. The methods and system further includes methods to determine the ranking and filter arrangements on the user interface, and methods to update filters.

Abstract: A method includes receiving an input histology image, processing, using a cell classification model, the input histology image to generate one or more lymphocyte density maps within the input histology image, and performing morphological image processing on the one or more lymphocyte density maps to identify one or more TLS regions within the input histology image. Each TLS region is represented by a respective cluster of lymphocyte cells. For each corresponding TLS region of the one or more TLS regions identified in the input histology image, the method also includes extracting, from the respective cluster of lymphocyte cells, a respective set of TLS features, and processing, using a TLS classification model, the respective set of TLS features to classify the corresponding TLS region as one of a first TLS maturation state, a second TLS maturation state, or a third TLS maturation state.

Abstract: Disclosed embodiments provide systems and methods for generating and presenting relevant product search results based on a user past purchase history. A method generating and presenting product search results based on past purchase history comprises retrieving a user product search query, a set of historical purchase data associated with the user, and a set of experimental data comprising a hierarchical list of product categories. The method further comprises determining a list of queried product categories based on a plurality of attributes and the pattern using machine learning algorithms. The method further comprises generating a hierarchical list of historical product categories associated with the user. The method further comprises generating a list of product search results associated with the user's product query. The method further comprises ranking the list of product search results based on the user's past purchase history and presenting the ranked list of product search results to the user.

Abstract: Disclosed embodiments provide systems and methods for identifying a target product and generating alternative product recommendations based on a user query. A computer-implemented system may be configured to perform operations comprising using machine learning to determine a plurality of attributes and at least one pattern associated with a user's product model number search query. The operations may further comprise determining at least one queried product of interest by the user and at least one product category based on an experimental data set. The operations may further comprise determining a target product based on the queried product of interest. The operations may further comprise determining a plurality of key features associated with the queried product based on experimental data, and determining at least one top alternative product. The operations may further comprise transmitting the target product and the top alternative product for display on an external device to the user.

Abstract: One aspect of the present disclosure is directed to a computer-implemented method for streamlined product searching. The method may include receiving a search query comprising at least one keyword; generating a listing of related products based on the keyword; ranking each related product based on applicability; determining a product type of at least the highest ranking related product; determining a filter sequence associated with the product type; generating a first record comprising the filter sequence; instantiating a second record of selected attributes; displaying a first filter in the filter sequence; receiving a first selected attribute from the first filter; displaying the second filter; receiving a second selected attribute from the second filter; and displaying a listing of products associated with the selected attributes in the second record.

Abstract: Systems and method are provided for AI-based product recommendation generation. One method includes, predicting, using a model, a plurality of recommended products, by determining a time span associated with a user identifier; retrieving at least one query submitted by a user associated with the user identifier during the time span; extracting attributes; determining a product category based on the extracted attributes; generating a list of products based on the determined product category; generating a list of recommended products based on the generated list of products; and modifying a user interface element associated with a webpage to include the generated list of recommended products.

Abstract: We queried DNA from saliva or plasma of 93 HNSCC patients, searching for somatic mutations or human papillomavirus genes, collectively referred to as tumor DNA. When both plasma and saliva were tested, tumor DNA was detected in 96% (95% CI, 84% to 99%) of 47 patients. The fractions of patients with detectable tumor DNA in early- and late-stage disease were 100% (n=10) and 95% (n=37), respectively. Saliva is preferentially enriched for tumor DNA from the oral cavity, whereas plasma is preferentially enriched for tumor DNA from the other sites. Tumor DNA in the saliva and plasma is a valuable biomarker for detection of HNSCC.

Abstract: Systems and method are provided for AI-based product recommendation generation. One method includes, predicting, using a model, a plurality of recommended products, by determining a time span associated with a user identifier; retrieving at least one query submitted by a user associated with the user identifier during the time span; extracting attributes; determining a product category based on the extracted attributes; generating a list of products based on the determined product category; generating a list of recommended products based on the generated list of products; and modifying a user interface element associated with a webpage to include the generated list of recommended products.

Abstract: One aspect of the present disclosure is directed to a computer-implemented system for streamlined product searching configured to receive a search query comprising at least one keyword; determine a product type; retrieve a first record of products associated with the product type; determine whether the search query meets a condition; and if the search query meets the condition: determine, a plurality of label values, and for each label value: generate a second record of products associated with the label value; determine whether each product in the second record meets a condition; deleting each product that meets the condition from the second record; ranking each remaining product in each second record; display the plurality of label values for selection; receive a selected label value; and display at least a portion of the remaining ranked products associated with the selected label value.

Abstract: We queried DNA from saliva or plasma of 93 HNSCC patients, searching for somatic mutations or human papillomavirus genes, collectively referred to as tumor DNA. When both plasma and saliva were tested, tumor DNA was detected in 96% (95% CI, 84% to 99%) of 47 patients. The fractions of patients with detectable tumor DNA in early- and late-stage disease were 100% (n=10) and 95% (n=37), respectively. Saliva is preferentially enriched for tumor DNA from the oral cavity, whereas plasma is preferentially enriched for tumor DNA from the other sites. Tumor DNA in the saliva and plasma is a valuable biomarker for detection of HNSCC.

Abstract: One aspect of the present disclosure is directed to a computer-implemented method for streamlined product searching. The method may include receiving a search query comprising at least one keyword; generating a listing of related products based on the keyword; ranking each related product based on applicability; determining a product type of at least the highest ranking related product; determining a filter sequence associated with the product type; generating a first record comprising the filter sequence; instantiating a second record of selected attributes; displaying a first filter in the filter sequence; receiving a first selected attribute from the first filter; displaying the second filter; receiving a second selected attribute from the second filter; and displaying a listing of products associated with the selected attributes in the second record.

Abstract: Efficient snapshot restore is disclosed. An indication to restore a snapshot from a replication destination to a storage system is received. At least a subset of data associated with the snapshot that is already present at the storage system is determined. A restore operation of the snapshot is performed by obtaining the at least subset of the data associated with the snapshot that is already present at the storage system locally from the storage system and by obtaining the remaining data associated with the snapshot from the replication destination.

Abstract: Oligodendrogliomas are the second most common malignant brain tumor in adults. These tumors often contain a chromosomal abnormality involving a pericentromeric fusion of chromosomes 1 and 19, resulting in losses of the entire short arm of the former and the long arm of the latter. To identify the molecular genetic basis for this alteration, we performed exomic sequencing of seven anaplastic oligodendrogliomas with chromosome 1p and 19q losses. Among other changes, we found that that CIC (homolog of the Drosophila gene capicua) on chromosome 19q was somatically mutated in six of the seven cases and that FUBP1 (far upstream element (FUSE) binding protein) on chromosome 1p was somatically mutated in two of the seven cases. Examination of 27 additional oligodendrogliomas revealed 12 and 3 more tumors with mutations of CIC and FUBP1, respectively, 58% of which were predicted to result in truncations of the encoded proteins.

Abstract: Oligodendrogliomas are the second most common malignant brain tumor in adults. These tumors often contain a chromosomal abnormality involving a pericentromeric fusion of chromosomes 1 and 19, resulting in losses of the entire short arm of the former and the long arm of the latter. To identify the molecular genetic basis for this alteration, we performed exomic sequencing of seven anaplastic oligodendrogliomas with chromosome 1p and 19q losses. Among other changes, we found that that CIC (homolog of the Drosophila gene capicua) on chromosome 19q was somatically mutated in six of the seven cases and that FUBP1 (far upstream element (FUSE) binding protein) on chromosome 1p was somatically mutated in two of the seven cases. Examination of 27 additional oligodendrogliomas revealed 12 and 3 more tumors with mutations of CIC and FUBP1, respectively, 58% of which were predicted to result in truncations of the encoded proteins.

Abstract: We queried DNA from saliva or plasma of 93 HNSCC patients, searching for somatic mutations or human papillomavirus genes, collectively referred to as tumor DNA. When both plasma and saliva were tested, tumor DNA was detected in 96% (95% CI, 84% to 99%) of 47 patients. The fractions of patients with detectable tumor DNA in early- and late-stage disease were 100% (n=10) and 95% (n=37), respectively. Saliva is preferentially enriched for tumor DNA from the oral cavity, whereas plasma is preferentially enriched for tumor DNA from the other sites. Tumor DNA in the saliva and plasma is a valuable biomarker for detection of HNSCC.

Abstract: Oligodendrogliomas are the second most common malignant brain tumor in adults. These tumors often contain a chromosomal abnormality involving a pericentromeric fusion of chromosomes 1 and 19, resulting in losses of the entire short arm of the former and the long arm of the latter. To identify the molecular genetic basis for this alteration, we performed exomic sequencing of seven anaplastic oligodendrogliomas with chromosome 1p and 19q losses. Among other changes, we found that that CIC (homolog of the Drosophila gene capicua) on chromosome 19q was somatically mutated in six of the seven cases and that FUBP1 (far upstream element (FUSE) binding protein) on chromosome 1p was somatically mutated in two of the seven cases. Examination of 27 additional oligodendrogliomas revealed 12 and 3 more tumors with mutations of CIC and FUBP1, respectively, 58% of which were predicted to result in truncations of the encoded proteins.