Abstract: Systems and methods are disclosed for conducting spinal cord stimulation or other neurostimulation and sensing evoked compound action potential (ECAP) signals. The sensed signals may be processed to isolate ECAP features from noise and/or interfering signals. The isolated ECAP features may be used to control neurostimulation therapy for the patient, such as to quantify or measure lead migration and adjust a neurostimulation therapy for the patient to account for an impact of any detected lead migration, or other purposes (e.g., to guide an implant procedure).

Abstract: One example method includes obtaining, from an endoscope and between first and second video frames of a real-time video having a frame rate, a preliminary image of a scene during a surgical procedure, the first image comprising a plurality of pixels, wherein the first and second video frames are consecutive video frames in the real-time video; determining, for each pixel of the plurality of pixels, a depth within the scene; determining first image capture parameters for the scene based on a scene illumination setting and a first set of pixels within a first range of depths in the scene; capturing, between the first and second consecutive output video frames, a first image using the first image capture parameters; determining an illumination correction for a second set of pixels at a second range of depths within the scene; capturing, between the first and second consecutive output video frames, a second image using the illumination correction; generating a composite image based on the first and second images;

Abstract: Real-time sensing of cerebrospinal fluid (CSF) clearance can be used to optimize electrode target engagement of the peripheral cranial nerves and detect associated changes within the connected nerve truck and brain. This CSF clearance data may be used in “open loop” systems to inform operator-controlled programming or sent directly to the stimulator itself to titrate programming “closed loop” on the device.

Abstract: Administration of low frequency electrical stimulation of the cranial nerves delivered during sleep increases the presence and function of aquaporin-4 (AQP4) channels in the astrocytic endfeet surrounding descending arterioles in the brain. This underlying low frequency stimulation pattern is overlaid with temporally patterned ‘bursts’ of higher frequency stimulation to pulse the underlying artery to drive cerebrospinal fluid (CSF) penetration into the parenchyma. This also serves to create more movement in general within the parenchymal extracellular space to increase the probability of waste biomolecules to interact with sites for active transport out of the brain. During the period of sleep, these two layered patterns will be periodically replaced with multiple continuous periods of stimulation at gamma frequency to promote a more phagocytic phenotype in glial cells to help break down waste biomolecules and misfolded proteins for subsequent clearance.

Abstract: Methods, endoscopic systems, and non-transitory, machine-readable storage media for adjusting an exposure of an endoscopic system are described. In an embodiment, the methods include emitting light with a light source into a proximal end of an endoscope light pipe; generating received light signals with a photodetector based on light received through the endoscope light pipe by the photodetector; displaying, with a display module, images based on the received light signals having a current image brightness; monitoring the received light signals for changes to the current image brightness; and adjusting a light source illuminance level, and in some embodiments a photodetector gain and exposure time, based on the current image brightness to maintain a target image brightness of the display module. In an embodiment, a brightness adjustment step size is less than a just-noticeable difference in brightness of an eye and is directly proportional to the current image brightness.

Abstract: Endoscopic systems, non-transitory, machine-readable storage media, and methods for correcting brightness non-uniformity are described. In an embodiment, the endoscopic system includes a light source positioned to emit illumination light onto a scene; a photodetector positioned to receive illumination light reflected off of the scene and configured to generate a scene signal based on the received illumination light; a display; and a controller operatively coupled to the light source, the photodetector, and the display.

Abstract: Systems and methods are disclosed for conducting spinal cord stimulation or other neurostimulation and sensing evoked compound action potential (ECAP) signals. The sensed signals may be processed to isolate ECAP features from noise and/or interfering signals. The isolated ECAP features may be used to control neurostimulation therapy for the patient and/or guide an implant procedure.

Abstract: Systems and methods are disclosed for conducting spinal cord stimulation or other neurostimulation and sensing evoked compound action potential (ECAP) signals. The sensed signals may be processed to isolate ECAP features from noise and/or interfering signals. The isolated ECAP features may be used to control neurostimulation therapy for the patient and/or guide an implant procedure.

Abstract: Systems and methods are disclosed for conducting spinal cord stimulation or other neurostimulation and sensing evoked compound action potential (ECAP) signals. The sensed signals may be processed to isolate ECAP features from noise and/or interfering signals. The isolated ECAP features may be used to control neurostimulation therapy for the patient and/or guide an implant procedure.

Abstract: Methods, endoscopic systems, and non-transitory, machine-readable storage media for adjusting an exposure of an endoscopic system are described. In an embodiment, the methods include emitting light with a light source into a proximal end of an endoscope light pipe; generating received light signals with a photodetector based on light received through the endoscope light pipe by the photodetector; displaying, with a display module, images based on the received light signals having a current image brightness; monitoring the received light signals for changes to the current image brightness; and adjusting a light source illuminance level, and in some embodiments a photodetector gain and exposure time, based on the current image brightness to maintain a target image brightness of the display module. In an embodiment, a brightness adjustment step size is less than a just-noticeable difference in brightness of an eye and is directly proportional to the current image brightness.

Abstract: Methods, endoscopic systems, and non-transitory, machine-readable storage media for adjusting an exposure of an endoscopic system are described. In an embodiment, the methods include emitting light with a light source into a proximal end of an endoscope light pipe; generating received light signals with a photodetector based on light received through the endoscope light pipe by the photodetector; displaying, with a display module, images based on the received light signals having a current image brightness; monitoring the received light signals for changes to the current image brightness; and adjusting a light source illuminance level, and in some embodiments a photodetector gain and exposure time, based on the current image brightness to maintain a target image brightness of the display module. In an embodiment, a brightness adjustment step size is less than a just-noticeable difference in brightness of an eye and is directly proportional to the current image brightness.

Abstract: An imaging system and method for imaging a scene using a rolling shutter are described. In an embodiment, the method includes illuminating a scene with first and second illumination light; generating frame signals with a photodetector comprising a plurality of pixels arranged in a plurality of rows, wherein the frame signals are based on light received from the scene with sequentially integrated rows of pixels of the plurality of rows, and wherein a frame signal includes signals from pixels of each of the plurality of rows; and generating images of the scene based on an intensity of the frame signals and the proportion of the first illumination light and the second illumination light emitted onto the scene during the first and second frames, wherein a proportion of the first illumination light and the second illumination light in a first frame is different than in a second frame.

Abstract: One example method for scene-adaptive image quality in surgical video includes receiving a first video frame from an endoscope, the first video frame generated from a first raw image captured by an image sensor of the endoscope and processed by an image signal processing (“ISP”) pipeline having a plurality of ISP parameters; recognizing, using a trained machine learning (“ML”) model, a first scene type or a first scene feature type based on the first video frame; determining a first set of ISP parameters based on the first scene type or the first scene feature type; applying the first set of ISP parameters to the ISP pipeline; and receiving a second video frame from the endoscope, the second video frame generated from a second raw image captured by the image sensor and processed by the ISP pipeline using the first set of ISP parameters.

Abstract: Systems and methods for specular reflection reduction in endoscope visualizations are described. A method includes receiving an image including a region of specular reflection. The method includes detecting the region of specular reflection in the image. The method includes estimating image information for a portion of the region of specular reflection. The method also includes reconstructing the image including the image information populated into the region of specular reflection.

Abstract: The disclosure describes new apparatus, systems and methods utilizing magnetoelectric neural stimulators with tunable amplitude and waveform. Specific embodiments of the present disclosure include a magnetoelectric film, a magnetic field generator and an electrical circuit coupled to the magnetoelectric film, in particular embodiments, the electrical circuit comprises components configured modify an electrical output signal produced by the magnetoelectric film. In certain embodiments, the electrical circuit is configured to modify the electric signal to charge a charge storage element, to transmit data to an implantable wireless neural stimulator, and to provide a stimulation output to electrodes.

Abstract: One example method includes obtaining, from an endoscope and between first and second video frames of a real-time video having a frame rate, a preliminary image of a scene during a surgical procedure, the first image comprising a plurality of pixels, wherein the first and second video frames are consecutive video frames in the real-time video; determining, for each pixel of the plurality of pixels, a depth within the scene; determining first image capture parameters for the scene based on a scene illumination setting and a first set of pixels within a first range of depths in the scene; capturing, between the first and second consecutive output video frames, a first image using the first image capture parameters; determining an illumination correction for a second set of pixels at a second range of depths within the scene; capturing, between the first and second consecutive output video frames, a second image using the illumination correction; generating a composite image based on the first and second images;

Abstract: An electrical stimulation system includes a stimulator having at least one electrode and a power supply. The electrode is connectable to the power supply, and the power supply delivers electrical stimulation energy in the form of a capacitive discharge voltage through the stimulator and electrode to tissue proximate a target anatomy to induce an observable response in the target anatomy during a medical procedure.

Abstract: An electrical stimulation system includes a stimulator having at least one electrode and a power supply. The electrode is connectable to the power supply, and the power supply delivers electrical stimulation energy in the form of a capacitive discharge voltage through the stimulator and electrode to tissue proximate a target anatomy to induce an observable response in the target anatomy during a medical procedure.

Abstract: Methods, endoscopic systems, and non-transitory, machine-readable storage media for adjusting an exposure of an endoscopic system are described. In an embodiment, the methods include emitting light with a light source into a proximal end of an endoscope light pipe; generating received light signals with a photodetector based on light received through the endoscope light pipe by the photodetector; displaying, with a display module, images based on the received light signals having a current image brightness; monitoring the received light signals for changes to the current image brightness; and adjusting a light source illuminance level, and in some embodiments a photodetector gain and exposure time, based on the current image brightness to maintain a target image brightness of the display module. In an embodiment, a brightness adjustment step size is less than a just-noticeable difference in brightness of an eye and is directly proportional to the current image brightness.

Abstract: An electrical stimulation system includes a stimulator having at least one electrode and a power supply. The electrode is connectable to the power supply, and the power supply delivers electrical stimulation energy in the form of a capacitive discharge voltage through the stimulator and electrode to tissue proximate a target anatomy to induce an observable response in the target anatomy during a medical procedure.